Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Kin-Wah Lee"'
Autor:
Yunong Xie, Haofeng Wu, Yimiao He, Linglin Liu, Ianto Bosheng Huang, Lei Zhou, Cheuk-Yin Lin, Rainbow Wing-Hei Leung, Jia-Jian Loh, Terence Kin-Wah Lee, Jin Ding, Kwan Man, Stephanie Ma, Man Tong
Publikováno v:
Cell Death and Disease, Vol 15, Iss 2, Pp 1-15 (2024)
Abstract Hepatocellular carcinoma (HCC) is an aggressive malignancy without effective therapeutic approaches. Here, we evaluate the tumor-intrinsic mechanisms that attenuate the efficacy of immune checkpoint inhibitor (ICI) that is observed in patien
Externí odkaz:
https://doaj.org/article/d8315cac64644c18a3125b5147874cd7
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide and has a poor prognosis. Although immune checkpoint inhibitors have entered a new era of HCC treatment, their response rates are modest, which can be attributed to th
Externí odkaz:
https://doaj.org/article/ce6aea33b01440bea89adb0b5859ae45
Autor:
Wing Ki Chau, Terence Kin Wah Lee
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105113- (2024)
Externí odkaz:
https://doaj.org/article/ee800bc3bfaf44bf95a0c7e75a317ec2
Autor:
Carmen Oi Ning Leung, Yang Yang, Rainbow Wing Hei Leung, Karl Kam Hei So, Hai Jun Guo, Martina Mang Leng Lei, Gregory Kenneth Muliawan, Yuan Gao, Qian Qian Yu, Jing Ping Yun, Stephanie Ma, Qian Zhao, Terence Kin Wah Lee
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Increasing evidence has demonstrated that drug resistance can be acquired in cancer cells by kinase rewiring, which is an obstacle for efficient cancer therapy. However, it is technically challenging to measure the expression of protein kina
Externí odkaz:
https://doaj.org/article/a856563b24ce4b1ea218f1222a27a71c
Autor:
Xiaozhe Zhang, Gao Shan, Na Li, Jingyi Chen, Changyang Ji, Xiaoxiao Li, Liwen Jiang, Terence Kin Wah Lee, Vincent W. Keng, Yanxiang Zhao
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Autophagy is a lysosome-dependent bulk degradation process essential for cell viability but excessive autophagy leads to a unique form of cell death termed autosis. Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breas
Externí odkaz:
https://doaj.org/article/208f1364bbdd4bc1ae0a42feda441890
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 4, Pp 985-999 (2023)
Primary liver cancer (PLC) includes hepatocellular carcinoma and intrahepatic cholangiocarcinoma and is the sixth most common cancer worldwide with poor prognosis. PLC is characterized by an abundant stromal reaction in which cancer-associated fibrob
Externí odkaz:
https://doaj.org/article/521fc4a858b94177a1ebdd294e7ef48a
Autor:
Jonathan D. Cybulski, Kit Sum Leung, Carmen Oi Ning Leung, David M. Baker, Terence Kin Wah Lee
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102506- (2023)
Summary: Cholesterol biosynthesis supports proliferation and drives resistance to tyrosine kinase inhibitor (TKI) therapy in hepatocellular carcinoma (HCC). Here, we present a protocol for using stable isotopic tracers to track the biosynthesis of ch
Externí odkaz:
https://doaj.org/article/aece1a8784524daf96df78805392605a
Autor:
Yi Xu, Yue Yao, Liang Yu, Xiaoxin Zhang, Xiaowen Mao, Sze Keong Tey, Samuel Wan Ki Wong, Cherlie Lot Sum Yeung, Tung Him Ng, Melody YM Wong, Chi‐Ming Che, Terence Kin Wah Lee, Yi Gao, Yunfu Cui, Judy Wai Ping Yam
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 8, Pp n/a-n/a (2023)
Abstract Small extracellular vesicles (sEVs) play a key role in exchanging cargoes between cells in tumour microenvironment. This study aimed to elucidate the functions and mechanisms of hepatocellular carcinoma (HCC) derived sEV‐clathrin light cha
Externí odkaz:
https://doaj.org/article/ac68c9a881f042b6a3823d140832ccae
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Coronavirus disease-19 (COVID-19), caused by SARS-CoV-2, has contributed to a significant increase in mortality. Proinflammatory cytokine-mediated cytokine release syndrome (CRS) contributes significantly to COVID-19. Meliae cortex has been reported
Externí odkaz:
https://doaj.org/article/9fd172f2b3714f7cb41dd213fac974fa
Autor:
Huang, Yu-Hua, Zhang, Chris Zhi-yi, Huang, Qun-Sheng, Yeong, Joe, Wang, Fang, Yang, Xia, He, Yang-Fan, Zhang, Xiao-Long, Zhang, Hua, Chen, Shi-Lu, Zheng, Yin-Li, Deng, Ru, Lin, Cen-Shan, Yang, Ming-Ming, Li, Yan, Jiang, Chen, Kin-Wah Lee, Terence, Ma, Stephanie, Zeng, Mu-Sheng, Yun, Jing-Ping
Publikováno v:
In Journal of Hepatology April 2021 74(4):838-849