Zobrazeno 1 - 10
of 848
pro vyhledávání: '"Kin Yip"'
Autor:
Shiqiang Xu, Qilian Ma, Junwen Shen, Ningning Li, Shan Sun, Nana Wang, Yang Chen, Chunsheng Dong, Kin Yip Tam, Jochen H.M. Prehn, Hongfeng Wang, Zheng Ying
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 5, Pp 2026-2038 (2024)
Growing evidences indicate that dysfunction of autophagy contributes to the disease pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two neurodegenerative disorders. The GGGGCC·GGCCCC repeat RNA expansion in chr
Externí odkaz:
https://doaj.org/article/dbd1fbe959004134a85764e04d7c0c51
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
PINK1 (PTEN induced kinase 1) and PRKN-mediated mitophagy is an important mitochondrial quality control pathway which selectively degrades damaged mitochondria and is tightly associated with neurodegenerative diseases, including Parkinson disease and
Externí odkaz:
https://doaj.org/article/eaa32c2b227f44b3b48853e7abf3ed15
Autor:
Ningning Li, Lingling Rao, Xueqing Zhao, Junwen Shen, Dan Su, Guoqiang Ma, Shan Sun, Qilian Ma, Li Zhang, Chunsheng Dong, Kin Yip Tam, Jochen H. M. Prehn, Hongfeng Wang, Zheng Ying
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Autophagy is a critical protein and organelle quality control system, which regulates cellular homeostasis and survival. Growing pieces of evidence suggest that autophagic dysfunction is strongly associated with many human diseases, including neurolo
Externí odkaz:
https://doaj.org/article/a249e2d9062a453b85a7be08c235801a
Autor:
Yaojun Ju, Kin Yip Tam
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 3, Pp 543-549 (2022)
Alzheimer’s disease is a rather complex neurodegenerative disease, which is attributed to a combination of multiple factors. Among the many pathological pathways, synaptic dysfunctions, such as synapses loss and deficits in synaptic plasticity, wer
Externí odkaz:
https://doaj.org/article/04a27e8dc7fe471d9c7707bfbceaf2af
Autor:
Weiming Lin, Feng Gao, Xia Wang, Nianhong Qin, Xianxiong Chen, Kin Yip Tam, Chengfei Zhang, Mingxia Zhang, Ou Sha
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2023)
Coronavirus disease 2019 (COVID-19) was reported to be associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, and patients present mostly with respiratory symptoms. There have been an increasing number of reports on o
Externí odkaz:
https://doaj.org/article/97108b56d8154fec96e0412c9216ddd1
Autor:
Wong, Kin Yip
Using Linear Response Theory, with appropriate wave functions and energies from perturbation method, the absorption profiles can be calculated for all three classes of mixed-valence systems as defined by Robin and Day : Class III (delocalized), Class
Externí odkaz:
http://arxiv.org/abs/2410.13144
Autor:
Kaifang Wang, Xiaona Wang, Minghuan Zhang, Zhenguang Ying, Zeyao Zhu, Kin Yip Tam, Chunman Li, Guowei Zhou, Feng Gao, Meiqi Zeng, Stephen Cho Wing Sze, Xia Wang, Ou Sha
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1416 (2023)
Trichosanthin (TCS) is a type I ribosome-inactivating protein extracted from the tuberous root of the plant Trichosanthes. TCS shows promising potential in clinical drug abortion, anti-tumor and immunological regulation. However, the molecular mechan
Externí odkaz:
https://doaj.org/article/5f0dfb391a48491abd91bef2941193f5
Publikováno v:
Translational Oncology, Vol 12, Iss 11, Pp 1516-1524 (2019)
Epidermal growth factor receptor (EGFR) mutations were found in 30%-40% of non–small cell lung cancer (NSCLC) patients, who often responded well to EGFR tyrosine kinase inhibitors (EGFR-TKIs) as exemplified by erlotinib and gefitinib in the past de
Externí odkaz:
https://doaj.org/article/7ea18533d2e849899f6f623c259acbba
Autor:
Xiaohui Hu, Kin Yip Tam
Publikováno v:
ADMET and DMPK, Vol 5, Iss 3, Pp 183-191 (2017)
Antibiotics play a pivotal role in modern medicine for the treatment of bacterial infection in patients. Membrane defines the boundary between single cell and its environment and is a main target for antibacterial agents. To better understand the mec
Externí odkaz:
https://doaj.org/article/f19cdd00686243c0839ea741fd72bbe6
Autor:
Yin Tian, Zechao Ding, Kin Yip Tam, Zhongyan Wang, Huiling Zhang, Dechun Zhao, Yi Zhao, Wei Xu, Shuxing Zheng
Publikováno v:
ADMET and DMPK, Vol 3, Iss 3, Pp 274-280 (2015)
Resting-state functional magnetic resonance imaging was utilized to measure the amplitude low frequency fluctuations (ALFF) in human subjects with Alzheimer’s disease (AD) and normal control (NC). Two specific frequency bands (Slow5: 0.01-0.027Hz a
Externí odkaz:
https://doaj.org/article/4561dbd8d4574328bb083c00803d20a5