Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kin S. Lam"'
Autor:
Barbara C. Potts, Kin S. Lam
Publikováno v:
Marine Drugs, Vol 8, Iss 4, Pp 835-880 (2010)
The salinosporamides are potent proteasome inhibitors among which the parent marine-derived natural product salinosporamide A (marizomib; NPI-0052; 1) is currently in clinical trials for the treatment of various cancers. Methods to generate this clas
Externí odkaz:
https://doaj.org/article/41e6ca02c2574891baf187d144d8ce11
Autor:
Irene M. Ghobrial, KC Anderson, Saskia T. C. Neuteboom, E. Valashi, G. K. Lloyd, William H. McBride, Paul G. Richardson, Barbara C. M. Potts, Joya Chandra, Huib Ovaa, Michael A. Palladino, Callum M. Sloss, Michael Groll, William Fenical, Aldo M. Roccaro, Frank Pajonk, Anas Younes, Y. Oki, James C. Cusack, Paul R. Jensen, Celia R. Berkers, Claudia P. Miller, M. X. Albitar, Stavroula Baritaki, Kin S. Lam, David J. McConkey, Ben Bonavida, D Chauhan, Matthew A. Spear
Publikováno v:
Current Cancer Drug Targets. 11:254-284
The proteasome has emerged as an important clinically relevant target for the treatment of hematologic malignancies. Since the Food and Drug Administration approved the first-in-class proteasome inhibitor bortezomib (Velcade®) for the treatment of r
Autor:
Kin S. Lam, Barbara C. M. Potts
Publikováno v:
Marine Drugs
Marine Drugs, Vol 8, Iss 4, Pp 835-880 (2010)
Marine Drugs, Vol 8, Iss 4, Pp 835-880 (2010)
The salinosporamides are potent proteasome inhibitors among which the parent marine-derived natural product salinosporamide A (marizomib; NPI-0052; 1) is currently in clinical trials for the treatment of various cancers. Methods to generate this clas
Autor:
Ginger Tsueng, Kin S. Lam
Publikováno v:
Applied Microbiology and Biotechnology. 80:873-880
We recently described the development of a potassium-chloride-based salt formulation containing low sodium concentration (5.0 mM) to support the growth of Salinispora tropica strain NPS21184 and its production of salinosporamide A (NPI-0052). In orde
Autor:
Ginger Tsueng, Kin S. Lam
Publikováno v:
Applied Microbiology and Biotechnology. 78:821-826
In this paper, we described the development of a potassium-chloride-based-salt formulation containing low sodium concentrations (5.0 to 11 mM) to support the growth of Salinispora tropica strain NPS21184 and its production of salinosporamide A (NPI-0
Autor:
Ginger Tsueng, Kin S. Lam
Publikováno v:
The Journal of Antibiotics. 60:469-472
Addition of acrylic resin Amberlite XAD-7 during the fermentation of Salinispora tropica significantly enhanced the production of NPI-0052 by 69 fold. Examination of the time course of resin addition to the Salinispora tropica fermentation demonstrat
Autor:
Saskia T. C. Neuteboom, Scott S Mitchell, Barbara C. M. Potts, Jianlin Xu, Gordafaried Deyanat-Yazdi, Sy Teisan, Ta-Hsiang Chao, Katherine Anne Reed, Rama Rao Manam, Kin S. Lam
Publikováno v:
Journal of Natural Products. 70:269-276
Salinosporamide A (NPI-0052; 3), a highly potent inhibitor of the 20S proteasome, is currently in phase I clinical trials for the treatment of cancer. During the course of purifying multigram quantities of 3 from Salinispora tropica fermentation extr
Autor:
Ginger Tsueng, Jianlin Xu, Scott S Mitchell, Barbara C. M. Potts, Katherine A. McArthur, Kin S. Lam
Publikováno v:
The Journal of Antibiotics. 60:13-19
We examined the effects of halogens on the production of salinosporamide A (NPI-0052) by the obligate marine actinomycete Salinispora tropica NPS465, specifically the production of analogs containing halogens other than chlorine. Adding NaF, NaBr and
Publikováno v:
Journal of Industrial Microbiology & Biotechnology. 33:523-531
Natural product compounds are the source of numerous therapeutic agents. Recent progress to discover drugs from natural product sources has resulted in compounds that are being developed to treat cancer, resistant bacteria and viruses and immunosuppr
Autor:
Gordafaried Deyanat-Yazdi, Ta-Hsiang Chao, Paul R. Jensen, Bao Mai, Kin S. Lam, Barbara C. M. Potts, Michael A. Palladino, William Fenical, Saskia T. C. Neuteboom, Katherine Anne Reed, Benjamin Nicholson, Scott S Mitchell, Rama Rao Manam, Venkat R. Macherla
Publikováno v:
Journal of Medicinal Chemistry. 48:3684-3687
Salinosporamide A (1, NPI-0052) is a potent proteasome inhibitor in development for treating cancer. In this study, a series of analogues was assayed for cytotoxicity, proteasome inhibition, and inhibition of NF-kappaB activation. Marked reductions i