Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kin Man Suen"'
Autor:
Christopher M. Jones, Arndt Rohwedder, Kin Man Suen, Safoura Zahed Mohajerani, Antonio N. Calabrese, Sabine Knipp, Mark T. Bedford, John E. Ladbury
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e35480- (2024)
Receptor tyrosine kinase (RTK) overexpression is linked to the development and progression of multiple cancers. RTKs are classically considered to initiate cytoplasmic signalling pathways via ligand-induced tyrosine phosphorylation, however recent ev
Externí odkaz:
https://doaj.org/article/756db033cc9a4969828da63cff6be9ba
Autor:
Chi-Chuan Lin, Lukasz Wieteska, Guillaume Poncet-Montange, Kin Man Suen, Stefan T. Arold, Zamal Ahmed, John E. Ladbury
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Receptor tyrosine kinases (RTKs) are typically activated through a precise sequence of intracellular phosphorylation events starting with a tyrosine residue on the activation loop (A-loop) of the kinase domain (KD). From this point the mono-
Externí odkaz:
https://doaj.org/article/1eb049e9217d4b42a3ef681bf1ba97aa
Autor:
Amy K. Stainthorp, Chi-Chuan Lin, Dapeng Wang, Ragini Medhi, Zamal Ahmed, Kin Man Suen, Eric A. Miska, Adrian Whitehouse, John E. Ladbury
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Protein interactions with the microRNA (miRNA)-mediated gene silencing protein Argonaute 2 (AGO2) control miRNA expression. miRNA biogenesis starts with the production of precursor transcripts and culminates with the loading of mature miRNA
Externí odkaz:
https://doaj.org/article/756e1110262445a7a318ca1ffe0841ca
Autor:
IC Navarro, Dalila Bensaddek, Kin Man Suen, Angus Lamond, Arun Tanpure, Eric A Miska, Shankar Balasubramanian
Publikováno v:
Wellcome Open Research, Vol 7 (2022)
Background: Methylation of carbon-5 of cytosines (m5C) is a conserved post-transcriptional nucleotide modification of RNA with widespread distribution across organisms. It can be further modified to yield 5-hydroxymethylcytidine (hm5C), 5-formylcytid
Externí odkaz:
https://doaj.org/article/7be7f37ee54c49e68426dbf39db16b70
Autor:
Chi-Chuan Lin, Lukasz Wieteska, Kin Man Suen, Arnout P. Kalverda, Zamal Ahmed, John E. Ladbury
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Lin et al. investigate the interactions between adaptor protein, Grb2, and the ubiquitously expressed protein tyrosine phosphatase, Shp2. They find that monomeric Grb2 can activate Shp2 and its downstream signalling in the absence of up-regulation of
Externí odkaz:
https://doaj.org/article/edb9c4facda0446e8198cbaac3dd988c
Autor:
Kin Man Suen, Fabian Braukmann, Richard Butler, Dalila Bensaddek, Alper Akay, Chi-Chuan Lin, Dovilė Milonaitytė, Neel Doshi, Alexandra Sapetschnig, Angus Lamond, John Edward Ladbury, Eric Alexander Miska
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The C. elegans PIWI protein PRG-1 resides in the membraneless organelle P granule. Here, the authors identify the constitutive P granule protein DEPS-1 as an interactor of PRG-1 and show its function in piRNA-dependent silencing. DEPS-1 and PRG-1 for
Externí odkaz:
https://doaj.org/article/41574a0478304ed5b2da4e86531e0f12
Publikováno v:
Trends in Biochemical Sciences. 48:428-436
Autor:
IC Navarro, Kin Man Suen, Dalila Bensaddek, Arun Tanpure, Angus Lamond, Shankar Balasubramanian, Eric A Miska
Background: Methylation of carbon-5 of cytosines (m5C) is a conserved post-transcriptional nucleotide modification of RNA with widespread distribution across organisms. It can be further modified to yield 5-hydroxymethylcytidine (hm5C), 5-formylcytid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7324a5177af23756e61d64427074590b
https://doi.org/10.1101/2022.01.24.477592
https://doi.org/10.1101/2022.01.24.477592
Autor:
Amy Stainthorp, Chi-Chuan Lin, Carlos A. Montanari, Andrei Leitão, John E. Ladbury, Lukasz Wieteska, Kin Man Suen, George S. Biggs
Publikováno v:
Cancer Letters
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Receptor tyrosine kinase (RTK)-mediated hyperactivation of the MAPK/Erk pathway is responsible for a large number of pathogenic outcomes including many cancers. Considerable effort has been directed at targeting this pathway with varying degrees of l
Autor:
Stefan T. Arold, Kin Man Suen, G. Poncet-Montange, Chi-Chuan Lin, John E. Ladbury, Lukasz Wieteska, Zamal Ahmed
Despite the kinetically-favorable, ATP-rich intracellular environment, the mechanism by which receptor tyrosine kinases (RTKs) repress activation prior to extracellular stimulation is poorly understood. RTKs are activated through a precise sequence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f27d1f4be57609d4e661f777b57c8d7c
https://doi.org/10.1101/2020.10.01.322123
https://doi.org/10.1101/2020.10.01.322123