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pro vyhledávání: '"Kin Jack Cheong"'
Publikováno v:
Advanced Synthesis & Catalysis. 359:3983-3989
N-Protected β- and γ-amino epoxides are useful chiral synthons. We report here that the enzyme cytochrome P450 3A4 can catalyze the formation of such compounds in a regio- and stereo-selective manner, even in the presence of multiple double bonds o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::947793429fdc88ff51b94d59268c978a
https://doi.org/10.1002/adsc.201700637
https://doi.org/10.1002/adsc.201700637
Publikováno v:
Chembiochem : a European journal of chemical biology. 18(3)
Substrate-promiscuous enzymes are a promising starting point for the development of versatile biocatalysts. In this study, human cytochrome P450 3A4, known for its ability to metabolise hundreds of drugs, was engineered to alter its regio- and stereo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdaa2da02a73b50a14fee24066da9c2c
https://pubmed.ncbi.nlm.nih.gov/27897366
https://pubmed.ncbi.nlm.nih.gov/27897366