Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Kimmo Rantalainen"'
Autor:
Rajesh P Ringe, Philippe Colin, Gabriel Ozorowski, Joel D Allen, Anila Yasmeen, Gemma E Seabright, Jeong Hyun Lee, Aleksandar Antanasijevic, Kimmo Rantalainen, Thomas Ketas, John P Moore, Andrew B Ward, Max Crispin, P J Klasse
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011601 (2023)
Neutralizing antibodies (NAbs) to multiple epitopes on the HIV-1-envelope glycoprotein (Env) have been isolated from infected persons. The potency of NAbs is measured more often than the size of the persistent fraction of infectivity at maximum neutr
Externí odkaz:
https://doaj.org/article/7568988b535a466f9fbb76d93f1b2ea9
Autor:
Aleksandar Antanasijevic, Leigh M. Sewall, Christopher A. Cottrell, Diane G. Carnathan, Luis E. Jimenez, Julia T. Ngo, Jennifer B. Silverman, Bettina Groschel, Erik Georgeson, Jinal Bhiman, Raiza Bastidas, Celia LaBranche, Joel D. Allen, Jeffrey Copps, Hailee R. Perrett, Kimmo Rantalainen, Fabien Cannac, Yuhe R. Yang, Alba Torrents de la Peña, Rebeca Froes Rocha, Zachary T. Berndsen, David Baker, Neil P. King, Rogier W. Sanders, John P. Moore, Shane Crotty, Max Crispin, David C. Montefiori, Dennis R. Burton, William R. Schief, Guido Silvestri, Andrew B. Ward
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Here, the authors present cryoEMPEM, a method for high-resolution structural analysis of vaccine-elicited polyclonal antibody responses. They apply cryoEMPEM in combination with standard serology experiments to characterize the polyclonal antibody (p
Externí odkaz:
https://doaj.org/article/04ab87746dbe4d4ea81ab039e453c3ac
Autor:
Lei Zhang, Adriana Irimia, Lingling He, Elise Landais, Kimmo Rantalainen, Daniel P. Leaman, Thomas Vollbrecht, Armando Stano, Daniel I. Sands, Arthur S. Kim, IAVI Protocol G Investigators, Pascal Poignard, Dennis R. Burton, Ben Murrell, Andrew B. Ward, Jiang Zhu, Ian A. Wilson, Michael B. Zwick
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Here, the authors identify a broadly neutralizing antibody from an HIV-infected person that recognizes the membrane-proximal external region (MPER) of HIV envelope glycoprotein (Env) and has a short CDRH3 and low polyreactivity. Structural analysis s
Externí odkaz:
https://doaj.org/article/706277bc9dfa4fb4814343163603b088
Autor:
Kwinten Sliepen, Byung Woo Han, Ilja Bontjer, Petra Mooij, Fernando Garces, Anna-Janina Behrens, Kimmo Rantalainen, Sonu Kumar, Anita Sarkar, Philip J. M. Brouwer, Yuanzi Hua, Monica Tolazzi, Edith Schermer, Jonathan L. Torres, Gabriel Ozorowski, Patricia van der Woude, Alba Torrents de la Peña, Mariëlle J. van Breemen, Juan Miguel Camacho-Sánchez, Judith A. Burger, Max Medina-Ramírez, Nuria González, Jose Alcami, Celia LaBranche, Gabriella Scarlatti, Marit J. van Gils, Max Crispin, David C. Montefiori, Andrew B. Ward, Gerrit Koopman, John P. Moore, Robin J. Shattock, Willy M. Bogers, Ian A. Wilson, Rogier W. Sanders
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Stabilized, native-like trimers of the HIV envelope protein, such as SOSIP trimers, are potential antigens for an HIV vaccine. Here, the authors generate a SOSIP trimer based on the consensus sequence of group M isolates, determine its structure and
Externí odkaz:
https://doaj.org/article/385d5edce0af48848af24fbfd3bba2e8
Autor:
Ronald Derking, Joel D. Allen, Christopher A. Cottrell, Kwinten Sliepen, Gemma E. Seabright, Wen-Hsin Lee, Yoann Aldon, Kimmo Rantalainen, Aleksandar Antanasijevic, Jeffrey Copps, Anila Yasmeen, Albert Cupo, Victor M. Cruz Portillo, Meliawati Poniman, Niki Bol, Patricia van der Woude, Steven W. de Taeye, Tom L.G.M. van den Kerkhof, P.J. Klasse, Gabriel Ozorowski, Marit J. van Gils, John P. Moore, Andrew B. Ward, Max Crispin, Rogier W. Sanders
Publikováno v:
Cell Reports, Vol 35, Iss 1, Pp 108933- (2021)
Summary: Artificial glycan holes on recombinant Env-based vaccines occur when a potential N-linked glycosylation site (PNGS) is under-occupied, but not on their viral counterparts. Native-like SOSIP trimers, including clinical candidates, contain suc
Externí odkaz:
https://doaj.org/article/d35ef609090b41f8811d3dde9f09ac63
Autor:
Kimmo Rantalainen, Zachary T. Berndsen, Aleksandar Antanasijevic, Torben Schiffner, Xi Zhang, Wen-Hsin Lee, Jonathan L. Torres, Lei Zhang, Adriana Irimia, Jeffrey Copps, Kenneth H. Zhou, Young D. Kwon, William H. Law, Chaim A. Schramm, Raffaello Verardi, Shelly J. Krebs, Peter D. Kwong, Nicole A. Doria-Rose, Ian A. Wilson, Michael B. Zwick, John R. Yates, III, William R. Schief, Andrew B. Ward
Publikováno v:
Cell Reports, Vol 31, Iss 4, Pp - (2020)
Summary: Structural and functional studies of HIV envelope glycoprotein (Env) as a transmembrane protein have long been complicated by challenges associated with inherent flexibility of the molecule and the membrane-embedded hydrophobic regions. Here
Externí odkaz:
https://doaj.org/article/d9f16fbf109a4f2f9110c0d89c79dd68
Autor:
Liwei Cao, Matthias Pauthner, Raiees Andrabi, Kimmo Rantalainen, Zachary Berndsen, Jolene K. Diedrich, Sergey Menis, Devin Sok, Raiza Bastidas, Sung-Kyu Robin Park, Claire M. Delahunty, Lin He, Javier Guenaga, Richard T. Wyatt, William R. Schief, Andrew B. Ward, John R. Yates, Dennis R. Burton, James C. Paulson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
HIV envelope (Env) is a potential vaccine antigen and its N-glycans are part of the epitope of broadly neutralizing antibodies. Here, the authors show that glycosylation of Env from infectious virus closely matches Env from recombinant membrane-bound
Externí odkaz:
https://doaj.org/article/4f20b420b7274e21b3fd2be2a1aa131b
Autor:
Kimmo Rantalainen, Zachary T. Berndsen, Sasha Murrell, Liwei Cao, Oluwarotimi Omorodion, Jonathan L. Torres, Mengyu Wu, Jeffrey Umotoy, Jeffrey Copps, Pascal Poignard, Elise Landais, James C. Paulson, Ian A. Wilson, Andrew B. Ward
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3249-3261 (2018)
Summary: Broadly neutralizing antibodies (bnAbs) targeting the HIV envelope glycoprotein (Env) typically take years to develop. Longitudinal analyses of both neutralizing antibody lineages and viruses at serial time points during infection provide a
Externí odkaz:
https://doaj.org/article/714ec341ba7649fd94d27283c71e0704
Autor:
Alba Torrents de la Peña, Kimmo Rantalainen, Christopher A Cottrell, Joel D Allen, Marit J van Gils, Jonathan L Torres, Max Crispin, Rogier W Sanders, Andrew B Ward
Publikováno v:
PLoS Pathogens, Vol 15, Iss 7, p e1007920 (2019)
The HIV-1 envelope glycoprotein (Env) trimer is located on the surface of the virus and is the target of broadly neutralizing antibodies (bNAbs). Recombinant native-like soluble Env trimer mimetics, such as SOSIP trimers, have taken a central role in
Externí odkaz:
https://doaj.org/article/657d2b89dfa946ecb5eb39f97b3be3f5
Autor:
Tom G. Caniels, Max Medina-Ramírez, Jinsong Zhang, Anita Sarkar, Sonu Kumar, Alex LaBranche, Ronald Derking, Joel D. Allen, Jonne L. Snitselaar, Joan Capella-Pujol, Iván del Moral Sánchez, Anila Yasmeen, Marilyn Diaz, Yoann Aldon, Tom P.L. Bijl, Sravani Venkatayogi, Joshua S. Martin Beem, Amanda Newman, Chuancang Jiang, Wen-Hsin Lee, Maarten Pater, Judith A. Burger, Mariëlle J. van Breemen, Steven W. de Taeye, Kimmo Rantalainen, Celia LaBranche, Kevin O. Saunders, David Montefiori, Gabriel Ozorowski, Andrew B. Ward, Max Crispin, John P. Moore, Per Johan Klasse, Barton F. Haynes, Ian A. Wilson, Kevin Wiehe, Laurent Verkoczy, Rogier W. Sanders
Publikováno v:
Cell Reports Medicine, 4(4):101003. Cell Press
Targeting germline (gl-) precursors of broadly neutralizing antibodies (bNAbs) is acknowledged as an important strategy for HIV-1 vaccines. The VRC01-class of bNAbs is attractive because of its distinct genetic signature. However, VRC01-class bNAbs o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0abe01ee8ed5d55e0d1a359126af9aa
https://pure.amc.nl/en/publications/germlinetargeting-hiv1-env-vaccination-induces-vrc01class-antibodies-with-rare-insertions(4a3cf33f-bbcf-4f4c-ad44-92262e9dbc5d).html
https://pure.amc.nl/en/publications/germlinetargeting-hiv1-env-vaccination-induces-vrc01class-antibodies-with-rare-insertions(4a3cf33f-bbcf-4f4c-ad44-92262e9dbc5d).html