The Finland–United States Investigation of Non–Insulin-Dependent Diabetes Mellitus Genetics (FUSION) Study. II. An Autosomal Genome Scan for Diabetes-Related Quantitative-Trait Loci

Autor: Richard C. McEachin, Gabriele Vidgren, William Hagopian, Tasha E. Fingerlin, Shane A. Shapiro, Christian Welch, Colin Martin, William L. Duren, Michael Boehnke, Johan G. Eriksson, Gunther Birznieks, William Eldridge, Ray Whiten, Liisa Toivanen, Julie A. Douglas, Zarir E. Karanjawala, Francis S. Collins, Thomas A. Buchanan, Soumitra Ghosh, Carl D. Langefeld, Anjene Musick, Jennie Chang, Stella J. Nylund, Timo T. Valle, Alistair So, Catherine Te, Chun Li, Leonid Segal, Karen L. Mohlke, Carrie Pfahl, Ravi Sharaf, Edna H. Ross, Rachel Porter, Richard M. Watanabe, Joseph B. Rayman, Eva Tuomilehto-Wolf, Elza Demirchyan, David Rha, Joyce Tannenbaum, Victoria L. Magnuson, Elizabeth R. Hauser, Michael P. Epstein, Kimmo Kohtamäki, Richard N. Bergman, Delphine S. Ally, Alyson Witt, Edward H. Trager, Ben Shurtleff, Kristina Kudelko, Jaakko Tuomilehto, Peggy P. White, Julie I. Knapp, Michael R. Erdos, Kaisa Silander, Peter S. Chines, Hong Shi Kaleta, James E. Balow, Christian Ehnholm, Heather M. Stringham, Arun M. Unni, Tiffany Musick, Jason Tovar, Jillian Blaschak-Harvan, Anabelle Morales-Mena, Ethan M. Lange

Publikováno v: The American Journal of Human Genetics. 67:1186-1200

Type 2 diabetes mellitus is a complex disorder encompassing multiple metabolic defects. We report results from an autosomal genome scan for type 2 diabetes-related quantitative traits in 580 Finnish families ascertained for an affected sibling pair a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60afb82ee87d3b201eb5e4c1a613b7db
https://doi.org/10.1016/s0002-9297(07)62949-8

Familiality of Quantitative Metabolic Traits in Finnish Families with Non-Insulin-Dependent Diabetes mellitus

Autor: Christian Ehnholm, Soumitra Ghosh, Kimmo Kohtamäki, Timo T. Valle, Richard N. Bergman, Francis S. Collins, Elizabeth R. Hauser, Johan G. Eriksson, Michael Boehnke, Jaakko Tuomilehto, Richard M. Watanabe

Publikováno v: Human Heredity. 49:159-168

Type 2 diabetes mellitus (NIDDM) is a complex disorder encompassing multiple metabolic defects. There exists strong evidence for a genetic component to NIDDM; however, to date there have been few reports of linkage between genetic markers along the g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d223c68fcf54ec29109238110066d19
https://doi.org/10.1159/000022865

Epidemiology of Insulin-Dependent Diabetes Mellitus Around the Baltic Sea

Autor: Jaakko Tuomilehto, Zilvinas Padaiga, Eva Tuomilehto-Wolf, Kimmo Kohtamäki, Marjatta Karvonen

Publikováno v: Hormone and Metabolic Research. 28:340-343

Great spatial variation in the incidence of IDDM is found among countries around the Baltic Sea, a relative small area on the global scale. We present recent data on IDDM incidence from countries around the Baltic Sea, monthly variation and time tren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::834472fd63f10f00c3108b4bb85cf076
https://doi.org/10.1055/s-2007-979810

Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs

Autor: Richard N. Bergman, Johan G. Eriksson, Gunther Birznieks, Eva Tuomilehto-Wolf, William Eldridge, Victoria L. Magnuson, Colin Martin, William Hagopian, Delphine S. Ally, Christian Ehnholm, Soumitra Ghosh, Alistair So, Rachel Porter, Jillian Blaschak-Harvan, Arun M. Unni, Michael R. Erdos, James E. Balow, Gabriele Vidgren, Michael Boehnke, Ben Shurtleff, Kimmo Kohtamäki, Kristina Kudelko, Jaakko Tuomilehto, Elizabeth R. Hauser, Anjene Musick, Jennie Chang, Thomas A. Buchanan, Carl D. Langefeld, Shane A. Shapiro, Ravi Sharaf, Hong-Shi Kaleta, Timo T. Valle, Francis S. Collins, Tuula Tenkula, Joyce Tannenbaum, Leonid Segal, Peter S. Chines, Catherine Te, Richard M. Watanabe, Alyson Witt

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 96(5)

We are conducting a genome scan at an average resolution of 10 centimorgans (cM) for type 2 diabetes susceptibility genes in 716 affected sib pairs from 477 Finnish families. To date, our best evidence for linkage is on chromosome 20 with potentially

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffe2748e75d7b9f00d0f8fe66f92274
https://pubmed.ncbi.nlm.nih.gov/10051618

Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study

Autor: Francis S. Collins, Gabriele Vidgren, Jillian Blaschak, William Hagopian, Timo T. Valle, Edna H. Ross, Victoria L. Magnuson, Delphine S. Ally, Jaakko Tuomilehto, Eva Tuomilehto-Wolf, Kimmo Kohtamäki, Richard M. Watanabe, Christian Ehnholm, Soumitra Ghosh, Carl D. Langefeld, Stella J. Nylund, Elizabeth R. Hauser, Johan G. Eriksson, Liisa Toivanen, Michael Boehnke, Thomas A. Buchanan, Richard N. Bergman

Publikováno v: Diabetes care. 21(6)

OBJECTIVE To map and identify susceptibility genes for NIDDM and for the intermediate quantitative traits associated with NIDDM. RESEARCH DESIGN AND METHODS We describe the methodology and sample of the Finland-United States Investigation of NIDDM Ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809aa08c31ef1db857cfaaf80638252c
https://pubmed.ncbi.nlm.nih.gov/9614613