Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Kimmo, Jokivarsi"'
Autor:
Mari Takalo, Rebekka Wittrahm, Benedikt Wefers, Samira Parhizkar, Kimmo Jokivarsi, Teemu Kuulasmaa, Petra Mäkinen, Henna Martiskainen, Wolfgang Wurst, Xianyuan Xiang, Mikael Marttinen, Pekka Poutiainen, Annakaisa Haapasalo, Mikko Hiltunen, Christian Haass
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-14 (2020)
Abstract Background Microglia-specific genetic variants are enriched in several neurodegenerative diseases, including Alzheimer’s disease (AD), implicating a central role for alterations of the innate immune system in the disease etiology. A rare c
Externí odkaz:
https://doaj.org/article/c122113eda2b4d76853cce27dfc51d97
Autor:
Szabolcs Felszeghy, Johanna Viiri, Jussi J. Paterno, Juha M.T. Hyttinen, Ali Koskela, Mei Chen, Henri Leinonen, Heikki Tanila, Niko Kivinen, Arto Koistinen, Elisa Toropainen, Marialaura Amadio, Adrian Smedowski, Mika Reinisalo, Mateusz Winiarczyk, Jerzy Mackiewicz, Maija Mutikainen, Anna-Kaisa Ruotsalainen, Mikko Kettunen, Kimmo Jokivarsi, Debasish Sinha, Kati Kinnunen, Goran Petrovski, Janusz Blasiak, Geir Bjørkøy, Ari Koskelainen, Heli Skottman, Arto Urtti, Antero Salminen, Ram Kannan, Deborah A. Ferrington, Heping Xu, Anna-Liisa Levonen, Pasi Tavi, Anu Kauppinen, Kai Kaarniranta
Publikováno v:
Redox Biology, Vol 20, Iss , Pp 1-12 (2019)
Age-related macular degeneration (AMD) is a multi-factorial disease that is the leading cause of irreversible and severe vision loss in the developed countries. It has been suggested that the pathogenesis of dry AMD involves impaired protein degradat
Externí odkaz:
https://doaj.org/article/623c13f35ca24a70a5117e36da09403d
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Sustained inflammation in the injured cortex is a promising therapeutic target for disease-modification after traumatic brain injury (TBI). However, its extent and dynamics of expansion are incompletely understood which challenges the timing and plac
Externí odkaz:
https://doaj.org/article/d0d4ede9c10c4f9d8850be7875e3e27c
Autor:
Petteri Stenroos, Jaakko Paasonen, Raimo A. Salo, Kimmo Jokivarsi, Artem Shatillo, Heikki Tanila, Olli Gröhn
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Functional magnetic resonance imaging (fMRI) is a powerful noninvasive tool for studying spontaneous resting state functional connectivity (RSFC) in laboratory animals. Brain function can be significantly affected by generally used anesthetics, howev
Externí odkaz:
https://doaj.org/article/63dba789f665421e91c1c612ee0c730b
Publikováno v:
International journal of pharmaceutics. 624
Nuclear medicine imaging plays an important role in nanomedicine. However, it is still challenging to develop a versatile platform to make the nonviral nanovectors used in cancer therapy biotraceable. In the present study, a robust approach to radiol
Autor:
Amna, Yasmin, Kimmo, Jokivarsi, Pekka, Poutiainen, Asla, Pitkänen, Olli, Gröhn, Riikka, Immonen
Publikováno v:
Brain Research. 1788:147934
Hippocampal and thalamo-cortico-striatal networks are critical for memory function as well as execution of a variety of learning strategies. In subjects with memory impairment as a sequel of traumatic brain injury (TBI), the contribution of late meta
Autor:
Salwa El-Tawil, Kimmo Jokivarsi, Bryony L. McGarry, Philip Clatworthy, Jennifer Elliot, Michael J. Knight, Robin A. Damion, Keith W. Muir, Risto A. Kauppinen, George Harston, Peter Jezzard, Rose Bosnell, Olli Gröhn, James Kennedy, Davide Carone
Publikováno v:
Knight, M, Damion, R, McGarry, B, Bosnell, R, Jokivarsi, K T, Grohn, O H J, Jezzard, P, Harston, G W J, Carone, D, Kennedy, J, El-Tawil, S, Elliot, J, Muir, K W, Clatworthy, P & Kauppinen, R 2019, ' Determining T2 relaxation time and stroke onset relationship in ischaemic stroke within apparent diffusion coefficient-defined lesions. A user-independent method for quantifying the impact of stroke in the human brain ', Biomedical Spectroscopy and Imaging, vol. 8, no. 1-2, pp. 1-18 . https://doi.org/10.3233/BSI-190185
Background and objective:In hyperacute ischaemic stroke, T2 of cerebral water increases with time. Quantifying this change may be informative of the extent of tissue damage and onset time. Our objective was to develop a user-unbiased method to measur
Autor:
Anna-Kaisa Ruotsalainen, Mikko I. Kettunen, Heping Xu, Maija Mutikainen, Goran Petrovski, Ali Koskela, Adrian Smedowski, Mika Reinisalo, Mateusz Winiarczyk, Heikki Tanila, Kai Kaarniranta, Juha M.T. Hyttinen, Szabolcs Felszeghy, Janusz Blasiak, Kati Kinnunen, Anna-Liisa Levonen, Pasi Tavi, Ari Koskelainen, Jussi J. Paterno, Debasish Sinha, Arto Urtti, Arto Koistinen, Jerzy Mackiewicz, Johanna Viiri, Heli Skottman, Elisa Toropainen, Marialaura Amadio, Ram Kannan, Niko Kivinen, Geir Bjørkøy, Deborah A. Ferrington, Henri Leinonen, Mei Chen, Kimmo Jokivarsi, Anu Kauppinen, Antero Salminen
Publikováno v:
Felszeghy, S, Viiri, J, Paterno, J J, Hyttinen, J M T, Koskela, A, Chen, M, Leinonen, H, Tanila, H, Kivinen, N, Koistinen, A, Toropainen, E, Amadio, M, Smedowski, A, Reinisalo, M, Winiarczyk, M, Mackiewicz, J, Mutikainen, M, Ruotsalainen, A K, Kettunen, M, Jokivarsi, K, Sinha, D, Kinnunen, K, Petrovski, G, Blasiak, J, Bjørkøy, G, Koskelainen, A, Skottman, H, Urtti, A, Salminen, A, Kannan, R, Ferrington, D A, Xu, H, Levonen, A L, Tavi, P, Kauppinen, A & Kaarniranta, K 2019, ' Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration ', Redox Biology, vol. 20, pp. 1-12 . https://doi.org/10.1016/j.redox.2018.09.011
Felszeghy, Viiri, Paterno, Hyttinen, Koskela,, Chen, M, Leinonen, Tanila, Kivinen, Koistinen, Totopainen, Amadio, Smedowski, Reinisalo, Winiarczyk, Mackiewicz, Mutikainen,, Xu, H & Kaarniranta 2019, ' Loss of NRF-2 and PGC-1a genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration ' Redox Biology, vol. 20, pp. 1-12 . https://doi.org/10.1016/j.redox.2018.09.011
Redox Biology
Redox Biology, Vol 20, Iss, Pp 1-12 (2019)
Felszeghy, Viiri, Paterno, Hyttinen, Koskela,, Chen, M, Leinonen, Tanila, Kivinen, Koistinen, Totopainen, Amadio, Smedowski, Reinisalo, Winiarczyk, Mackiewicz, Mutikainen,, Xu, H & Kaarniranta 2019, ' Loss of NRF-2 and PGC-1a genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration ' Redox Biology, vol. 20, pp. 1-12 . https://doi.org/10.1016/j.redox.2018.09.011
Redox Biology
Redox Biology, Vol 20, Iss, Pp 1-12 (2019)
Age-related macular degeneration (AMD) is a multi-factorial disease that is the leading cause of irreversible and severe vision loss in the developed countries. It has been suggested that the pathogenesis of dry AMD involves impaired protein degradat
Autor:
Yanyan Guo, Hushan Yuan, Hoonsung Cho, Darshini Kuruppu, Kimmo Jokivarsi, Aayush Agarwal, Khalid Shah, Lee Josephson
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58290 (2013)
Here we introduce diffusion molecular retention (DMR) tumor targeting, a technique that employs PEG-fluorochrome shielded probes that, after a peritumoral (PT) injection, undergo slow vascular uptake and extensive interstitial diffusion, with tumor r
Externí odkaz:
https://doaj.org/article/007e703cf285456c9af33d9d528954b9
Autor:
Petra Mäkinen, Pekka Poutiainen, Samira Parhizkar, Christian Haass, Kimmo Jokivarsi, Annakaisa Haapasalo, Mari Takalo, Mikael Marttinen, Henna Martiskainen, Benedikt Wefers, Mikko Hiltunen, Rebekka Wittrahm, Xianyuan Xiang, Wolfgang Wurst, Teemu Kuulasmaa
BackgroundMicroglia-specific genetic variants are enriched in several neurodegenerative diseases, including Alzheimer’s disease (AD), implicating a central role for alterations of the innate immune system in the disease etiology. A rare coding vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8418f3cf9805dffb85d0e1f96132cc
https://doi.org/10.1101/2020.04.08.031567
https://doi.org/10.1101/2020.04.08.031567