Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Kimmo, Jensen"'
Publikováno v:
BMC Neurology, Vol 23, Iss 1, Pp 1-5 (2023)
Abstract Background α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors mediate excitatory neurotransmission in the brain and may be targeted by autoantibodies, leading to autoimmune synaptic enceph
Externí odkaz:
https://doaj.org/article/539556a57c054c83bb1f510d5cce711b
Autor:
Zita Dósa, Jose Luis Nieto-Gonzalez, Betina Elfving, Karin Sørig Hougaard, Mai Marie Holm, Gregers Wegener, Kimmo Jensen
Publikováno v:
Dósa, Z, Nieto-Gonzalez, J L, Elfving, B, Hougaard, K S, Holm, M M, Wegener, G & Jensen, K 2023, ' Reduction in hippocampal GABAergic transmission in a low birth weight rat model of depression ', Acta Neuropsychiatrica . https://doi.org/10.1017/neu.2023.18
Dósa, Z, Nieto-Gonzalez, J L, Elfving, B, Hougaard, K S, Holm, M M, Wegener, G & Jensen, K 2023, ' Reduction in hippocampal GABAergic transmission in a low birth weight rat model of depression ', Acta Neuropsychiatrica, pp. 1-34 . https://doi.org/10.1017/neu.2023.18
Dósa, Z, Nieto-Gonzalez, J L, Elfving, B, Hougaard, K S, Holm, M M, Wegener, G & Jensen, K 2023, ' Reduction in hippocampal GABAergic transmission in a low birth weight rat model of depression ', Acta Neuropsychiatrica, pp. 1-34 . https://doi.org/10.1017/neu.2023.18
Prenatal stress is believed to increase the risk of developing neuropsychiatric disorders, including major depression. Adverse genetic and environmental impacts during early development, such as glucocorticoid hyper-exposure, can lead to changes in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d88e94868ca6f9025a4ad1c9fe62065
https://vbn.aau.dk/da/publications/4dff46a1-4d7f-433f-8491-4484351710c6
https://vbn.aau.dk/da/publications/4dff46a1-4d7f-433f-8491-4484351710c6
Autor:
Boldizsár Czéh, Irina Vardya, Zsófia Varga, Fabia Febbraro, Dávid Csabai, Lena-Sophie Martis, Kristoffer Højgaard, Kim Henningsen, Elena V. Bouzinova, Attila Miseta, Kimmo Jensen, Ove Wiborg
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Clinical and experimental data suggest that fronto-cortical GABAergic deficits contribute to the pathophysiology of major depressive disorder (MDD). To further test this hypothesis, we used a well characterized rat model for depression and examined t
Externí odkaz:
https://doaj.org/article/1f9cec32c8334b099dd1944bec6da17a
Autor:
Jose Luis Nieto-Gonzalez, Mai Marie Holm, Irina Vardya, Trine Christensen, Ove Wiborg, Kimmo Jensen
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119993 (2015)
Two main questions are important for understanding and treating affective disorders: why are certain individuals susceptible or resilient to stress, and what are the features of treatment response and resistance? To address these questions, we used a
Externí odkaz:
https://doaj.org/article/4b99d3944060489cbb81ac35b21b0f25
Autor:
Jose Luis Nieto-Gonzalez, Kimmo Jensen
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67318 (2013)
In addition to their classical roles in neuronal growth, survival and differentiation, neurotrophins are also rapid regulators of excitability, synaptic transmission and activity-dependent synaptic plasticity. We have recently shown that mature BDNF
Externí odkaz:
https://doaj.org/article/e4bc923c531e48779517804c08cda89c
Autor:
Karina D Thielsen, Jakob M Moser, Thomas Schmitt-John, Morten S Jensen, Kimmo Jensen, Mai Marie Holm
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82767 (2013)
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease. It is a fatal degenerative disease, best recognized for its debilitating neuromuscular effects. ALS however also induces cognitive impairments in as many as 50%
Externí odkaz:
https://doaj.org/article/24faec7e6b034d17a62018fe14cfd562
Autor:
Andrew H. Smith, Ulrik Bølcho, Christian Bjerggaard Vaegter, Jens R. Nyengaard, Anders Nykjaer, Kimmo Jensen, Thomas E. Willnow, S Bøggild, Simon Glerup, Simon Molgaard, L F Pedersen, Mai Marie Holm, Mads Kjolby, P L Ovesen, Hande Login, Olav M. Andersen, Anja W. Fjorback, Jose Luis Nieto-Gonzalez
Publikováno v:
Glerup, S, Bolcho, U, Bøggild, S, Vaegter, C B, Smith, A H, Nieto-Gonzalez, J L, Ovesen, P L, Pedersen, L F, Fjorback, A N, Kjolby, M, Login, H, Holm, M M, Andersen, O M, Nyengaard, J R, Willnow, T E, Jensen, K, Nykjaer, A & Jensen, S M 2016, ' SorCS2 is required for BDNF-dependent plasticity in the hippocampus ', Molecular Psychiatry . https://doi.org/10.1038/mp.2016.108
SorCS2 is a member of the Vps10p-domain receptor gene family receptors with critical roles in the control of neuronal viability and function. Several genetic studies have suggested SORCS2 to confer risk of bipolar disorder, schizophrenia and attentio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df9bd8c77313960491ff21c27c9835d
https://doi.org/10.1038/mp.2016.108
https://doi.org/10.1038/mp.2016.108
Autor:
Navnath Gavande, Silke Neumann, Kimmo Jensen, Liang Jin, Emma K. Gowing, Petra S. van Nieuwenhuijzen, Andrew N. Clarkson, Raghavendra Y. Nagaraja, Mai Marie Holm, Lily Boothman-Burrell, Jane R. Hanrahan, Philip K. Ahring, Zita Dósa, Mary Chebib, Kim Parker, Joseph A. Nicolazzo
Publikováno v:
J Cereb Blood Flow Metab
Clarkson, A N, Boothman-Burrell, L, Dósa, Z, Nagaraja, R Y, Jin, L, Parker, K, van Nieuwenhuijzen, P S, Neumann, S, Gowing, E K, Gavande, N, Ahring, P K, Holm, M M, Hanrahan, J R, Nicolazzo, J A, Jensen, K & Chebib, M 2019, ' The flavonoid, 2′-methoxy-6-methylflavone, affords neuroprotection following focal cerebral ischaemia ', Journal of Cerebral Blood Flow and Metabolism, vol. 39, no. 7, pp. 1266-1282 . https://doi.org/10.1177/0271678X18755628
Clarkson, A N, Boothman-Burrell, L, Dósa, Z, Nagaraja, R Y, Jin, L, Parker, K, van Nieuwenhuijzen, P S, Neumann, S, Gowing, E K, Gavande, N, Ahring, P K, Holm, M M, Hanrahan, J R, Nicolazzo, J A, Jensen, K & Chebib, M 2019, ' The flavonoid, 2′-methoxy-6-methylflavone, affords neuroprotection following focal cerebral ischaemia ', Journal of Cerebral Blood Flow and Metabolism, vol. 39, no. 7, pp. 1266-1282 . https://doi.org/10.1177/0271678X18755628
Tonic inhibitory currents, mediated by extrasynaptic GABAA receptors, are elevated at a delay following stroke. Flavonoids minimise the extent of cellular damage following stroke, but little is known about their mode of action. We demonstrate that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23252fd92bcc693fedd8c805be224df9
https://pubmed.ncbi.nlm.nih.gov/29376464
https://pubmed.ncbi.nlm.nih.gov/29376464
Autor:
Mads E. Hauberg, Kimmo Jensen, Anto P. Rajkumar, Ole Mors, Ernst-Martin Füchtbauer, Kim Fejgin, Jonatan Pallesen, Irina Vardya, Veerle Paternoster, Mads Dyrvig, Arne Mørk, Birgitte Lundsberg, Jane H. Christensen, Tue Fryland, Mette Nyegaard, Per Qvist, Anders D. Børglum, Jens R. Nyengaard, Michael Didriksen
Publikováno v:
Qvist, P, Christensen, J H, Vardya, I, Rajkumar, A P, Mørk, A, Paternoster, V, Füchtbauer, E-M, Pallesen, J, Fryland, T, Dyrvig, M, Hauberg, M E, Lundsberg, B, Fejgin, K, Nyegaard, M, Jensen, K, Nyengaard, J R, Mors, O, Didriksen, M & Børglum, A D 2017, ' The schizophrenia-associated BRD1 gene regulates behavior, neurotransmission, and expression of schizophrenia risk enriched gene sets in mice ', Biological Psychiatry, vol. 82, no. 1, pp. 62-76 . https://doi.org/10.1016/j.biopsych.2016.08.037
Qvist, P, Christensen, J H, Vardya, I, Rajkumar, A P, Mørk, A, Paternoster, V, Füchtbauer, E-M, Pallesen, J, Fryland, T, Dyrvig, M, Hauberg, M E, Lundsberg, B, Fejgin, K, Nyegaard, M, Jensen, K, Nyengaard, J R, Mors, O, Didriksen, M & Børglum, A D 2017, ' The Schizophrenia-Associated BRD1 Gene Regulates Behavior, Neurotransmission, and Expression of Schizophrenia Risk Enriched Gene Sets in Mice ', Biological Psychiatry, vol. 82, no. 1, pp. 62-76 . https://doi.org/10.1016/j.biopsych.2016.08.037
Qvist, P, Christensen, J H, Vardya, I, Rajkumar, A P, Mørk, A, Paternoster, V, Füchtbauer, E-M, Pallesen, J, Fryland, T, Dyrvig, M, Hauberg, M E, Lundsberg, B, Fejgin, K, Nyegaard, M, Jensen, K, Nyengaard, J R, Mors, O, Didriksen, M & Børglum, A D 2016, ' The schizophrenia associated BRD1 gene regulates behavior, neurotransmission, and expression of schizophrenia risk enriched gene sets in mice ', Biological psychiatry . https://doi.org/10.1016/j.biopsych.2016.08.037
Qvist, P, Christensen, J H, Vardya, I, Rajkumar, A P, Mørk, A, Paternoster, V, Füchtbauer, E-M, Pallesen, J, Fryland, T, Dyrvig, M, Hauberg, M E, Lundsberg, B, Fejgin, K, Nyegaard, M, Jensen, K, Nyengaard, J R, Mors, O, Didriksen, M & Børglum, A D 2017, ' The Schizophrenia-Associated BRD1 Gene Regulates Behavior, Neurotransmission, and Expression of Schizophrenia Risk Enriched Gene Sets in Mice ', Biological Psychiatry, vol. 82, no. 1, pp. 62-76 . https://doi.org/10.1016/j.biopsych.2016.08.037
Qvist, P, Christensen, J H, Vardya, I, Rajkumar, A P, Mørk, A, Paternoster, V, Füchtbauer, E-M, Pallesen, J, Fryland, T, Dyrvig, M, Hauberg, M E, Lundsberg, B, Fejgin, K, Nyegaard, M, Jensen, K, Nyengaard, J R, Mors, O, Didriksen, M & Børglum, A D 2016, ' The schizophrenia associated BRD1 gene regulates behavior, neurotransmission, and expression of schizophrenia risk enriched gene sets in mice ', Biological psychiatry . https://doi.org/10.1016/j.biopsych.2016.08.037
Background The schizophrenia-associated BRD1 gene encodes a transcriptional regulator whose comprehensive chromatin interactome is enriched with schizophrenia risk genes. However, the biology underlying the disease association of BRD1 remains specula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7197cdf2a824af3d701dbcabe7526cbc
https://vbn.aau.dk/da/publications/8469c96c-3ae2-4a7d-b7d0-ab3dd45c4d45
https://vbn.aau.dk/da/publications/8469c96c-3ae2-4a7d-b7d0-ab3dd45c4d45
Publikováno v:
Delenclos, M, Carrascal, L, Jensen, K & Romero-Ramos, M 2014, ' Immunolocalization of human alpha-synuclein in the Thy1-aSyn ("Line 61") transgenic mouse line ', Neuroscience . https://doi.org/10.1016/j.neuroscience.2014.07.042
Alpha-synuclein (a-syn) is the major component of the intracytoplasmic inclusions known as Lewy bodies (LB), which constitute the hallmark of Parkinson's disease (PD). Mice overexpressing human a-syn under the Thy-1 promoter (ASO) show slow neurodege
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8424e28d6d697dca97a25f1ed043068
https://doi.org/10.1016/j.neuroscience.2014.07.042
https://doi.org/10.1016/j.neuroscience.2014.07.042