Autophagy prevents early proinflammatory responses and neutrophil recruitment during Mycobacterium tuberculosis infection without affecting pathogen burden in macrophages.

Autor: Kinsella RL; Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, United States of America., Kimmey JM; Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, United States of America., Smirnov A; Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, United States of America., Woodson R; Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, United States of America., Gaggioli MR; Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, United States of America., Chavez SM; Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, United States of America., Kreamalmeyer D; Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, United States of America., Stallings CL; Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, United States of America.

Publikováno v: PLoS biology [PLoS Biol] 2023 Jun 15; Vol. 21 (6), pp. e3002159. Date of Electronic Publication: 2023 Jun 15 (Print Publication: 2023).

Neutrophil Recruitment in Pneumococcal Pneumonia.

Autor: Palmer CS; Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, CA, United States., Kimmey JM; Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, CA, United States.

Publikováno v: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 May 13; Vol. 12, pp. 894644. Date of Electronic Publication: 2022 May 13 (Print Publication: 2022).

Hypoxia-Inducible Factor 1 Alpha Is Dispensable for Host Defense of Group B Streptococcus Colonization and Infection.

Autor: Lum GR; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, UC San Diego, La Jolla, California, USA., Mercado V; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA., van Ens D; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, UC San Diego, La Jolla, California, USA., Nizet V; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, UC San Diego, La Jolla, California, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, California, USA., Kimmey JM; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, UC San Diego, La Jolla, California, USA.; Department of Microbiology and Environmental Toxicology, UC Santa Cruz, Santa Cruz, California, USA., Patras KA; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, UC San Diego, La Jolla, California, USA.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.; Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston, Texas, USA.

Publikováno v: Journal of innate immunity [J Innate Immun] 2021; Vol. 13 (6), pp. 391-403. Date of Electronic Publication: 2021 May 21.

The Pseudomonas aeruginosa protease LasB directly activates IL-1β.

Autor: Sun J; Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, CA, United States., LaRock DL; Department of Microbiology and Immunology, Emory School of Medicine, Atlanta GA, United States., Skowronski EA; Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, CA, United States., Kimmey JM; Department of Pediatrics, UC San Diego, La Jolla, CA, United States., Olson J; Department of Pediatrics, UC San Diego, La Jolla, CA, United States., Jiang Z; Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, CA, United States., O'Donoghue AJ; Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, CA, United States., Nizet V; Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, CA, United States; Department of Pediatrics, UC San Diego, La Jolla, CA, United States., LaRock CN; Department of Microbiology and Immunology, Emory School of Medicine, Atlanta GA, United States; Division of Infectious Diseases, Emory School of Medicine, Atlanta GA, United States; Antimicrobial Resistance Center, Emory University, Atlanta GA, United States. Electronic address: christopher.larock@emory.edu.

Publikováno v: EBioMedicine [EBioMedicine] 2020 Oct; Vol. 60, pp. 102984. Date of Electronic Publication: 2020 Sep 23.

Developmental Immaturity of Siglec Receptor Expression on Neonatal Alveolar Macrophages Predisposes to Severe Group B Streptococcal Infection.

Autor: Lund SJ; Department of Pediatrics, University of California, San Diego, Rady Children's Hospital, San Diego, 9500 Gilman Drive, Mail Code 0760, La Jolla, CA 92093-0760, USA., Patras KA; Department of Pediatrics, University of California, San Diego, Rady Children's Hospital, San Diego, 9500 Gilman Drive, Mail Code 0760, La Jolla, CA 92093-0760, USA., Kimmey JM; Department of Pediatrics, University of California, San Diego, Rady Children's Hospital, San Diego, 9500 Gilman Drive, Mail Code 0760, La Jolla, CA 92093-0760, USA., Yamamura A; Department of Pediatrics, University of California, San Diego, Rady Children's Hospital, San Diego, 9500 Gilman Drive, Mail Code 0760, La Jolla, CA 92093-0760, USA., Butcher LD; Department of Pediatrics, University of California, San Diego, Rady Children's Hospital, San Diego, 9500 Gilman Drive, Mail Code 0760, La Jolla, CA 92093-0760, USA., Del Rosario PGB; Department of Pediatrics, University of California, San Diego, Rady Children's Hospital, San Diego, 9500 Gilman Drive, Mail Code 0760, La Jolla, CA 92093-0760, USA., Hernandez GE; Department of Pediatrics, University of California, San Diego, Rady Children's Hospital, San Diego, 9500 Gilman Drive, Mail Code 0760, La Jolla, CA 92093-0760, USA., McCoy AM; Department of Pediatrics, University of California, San Diego, Rady Children's Hospital, San Diego, 9500 Gilman Drive, Mail Code 0760, La Jolla, CA 92093-0760, USA., Lakhdari O; Department of Pediatrics, University of California, San Diego, Rady Children's Hospital, San Diego, 9500 Gilman Drive, Mail Code 0760, La Jolla, CA 92093-0760, USA., Nizet V; Department of Pediatrics, University of California, San Diego, Rady Children's Hospital, San Diego, 9500 Gilman Drive, Mail Code 0760, La Jolla, CA 92093-0760, USA., Prince LS; Department of Pediatrics, University of California, San Diego, Rady Children's Hospital, San Diego, 9500 Gilman Drive, Mail Code 0760, La Jolla, CA 92093-0760, USA. Electronic address: lprinceucsd@gmail.com.

Publikováno v: IScience [iScience] 2020 Jun 26; Vol. 23 (6), pp. 101207. Date of Electronic Publication: 2020 May 28.