A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo.

Autor: Taha TY; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, United States of America.; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America., Suryawanshi RK; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, United States of America.; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America., Chen IP; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, United States of America.; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America.; Department of Medicine, University of California, San Francisco, California, United States of America., Correy GJ; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America., McCavitt-Malvido M; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, United States of America.; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America., O'Leary PC; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America.; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States of America., Jogalekar MP; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America.; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States of America., Diolaiti ME; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America.; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States of America., Kimmerly GR; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, United States of America., Tsou CL; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, United States of America., Gascon R; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, United States of America., Montano M; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, United States of America., Martinez-Sobrido L; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America.; Texas Biomedical Research Institute, San Antonio, Texas, United States of America., Krogan NJ; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America.; Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, California, United States of America.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, California, United States of America.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America., Ashworth A; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America.; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States of America., Fraser JS; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America., Ott M; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, United States of America.; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America.; Department of Medicine, University of California, San Francisco, California, United States of America.; Chan Zuckerberg Biohub-San Francisco, San Francisco, California, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2023 Aug 31; Vol. 19 (8), pp. e1011614. Date of Electronic Publication: 2023 Aug 31 (Print Publication: 2023).

Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA.1 variant through NSP6.

Autor: Taha TY; Gladstone Institutes, San Francisco, CA, USA. taha.taha@gladstone.ucsf.edu., Chen IP; Gladstone Institutes, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, CA, USA., Hayashi JM; Gladstone Institutes, San Francisco, CA, USA., Tabata T; Gladstone Institutes, San Francisco, CA, USA., Walcott K; Gladstone Institutes, San Francisco, CA, USA., Kimmerly GR; Gladstone Institutes, San Francisco, CA, USA., Syed AM; Gladstone Institutes, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, CA, USA., Ciling A; Gladstone Institutes, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, CA, USA., Suryawanshi RK; Gladstone Institutes, San Francisco, CA, USA., Martin HS; Gladstone Institutes, San Francisco, CA, USA.; Department of Chemistry, University of California, Berkeley, CA, USA., Bach BH; Innovative Genomics Institute, University of California, Berkeley, CA, USA., Tsou CL; Gladstone Institutes, San Francisco, CA, USA., Montano M; Gladstone Institutes, San Francisco, CA, USA., Khalid MM; Gladstone Institutes, San Francisco, CA, USA., Sreekumar BK; Gladstone Institutes, San Francisco, CA, USA., Renuka Kumar G; Gladstone Institutes, San Francisco, CA, USA., Wyman S; Innovative Genomics Institute, University of California, Berkeley, CA, USA., Doudna JA; Gladstone Institutes, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, CA, USA.; Department of Chemistry, University of California, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California, Berkeley, CA, USA.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, CA, USA., Ott M; Gladstone Institutes, San Francisco, CA, USA. melanie.ott@gladstone.ucsf.edu.; Department of Medicine, University of California, San Francisco, CA, USA. melanie.ott@gladstone.ucsf.edu.; Chan Zuckerberg Biohub - San Francisco, San Francisco, CA, USA. melanie.ott@gladstone.ucsf.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Apr 21; Vol. 14 (1), pp. 2308. Date of Electronic Publication: 2023 Apr 21.

Modified Manufacturing Process Modulates CD19CAR T-cell Engraftment Fitness and Leukemia-Free Survival in Pediatric and Young Adult Subjects.

Autor: Ceppi F; Research Division, Seattle Children's Hospital, Seattle, Washington.; Pediatric Hematology-Oncology Unit, Division of Pediatrics, University Hospital of Lausanne, Lausanne, Switzerland., Wilson AL; Research Division, Seattle Children's Hospital, Seattle, Washington., Annesley C; Research Division, Seattle Children's Hospital, Seattle, Washington.; University of Washington, Department of Pediatrics, Seattle, Washington., Kimmerly GR; Research Division, Seattle Children's Hospital, Seattle, Washington., Summers C; Research Division, Seattle Children's Hospital, Seattle, Washington.; University of Washington, Department of Pediatrics, Seattle, Washington.; Fred Hutchinson Cancer Research Center, Seattle, Washington., Brand A; Research Division, Seattle Children's Hospital, Seattle, Washington., Seidel K; Research Division, Seattle Children's Hospital, Seattle, Washington., Wu QV; Fred Hutchinson Cancer Research Center, Seattle, Washington., Beebe A; Research Division, Seattle Children's Hospital, Seattle, Washington., Brown C; Research Division, Seattle Children's Hospital, Seattle, Washington., Mgebroff S; Research Division, Seattle Children's Hospital, Seattle, Washington., Lindgren C; Research Division, Seattle Children's Hospital, Seattle, Washington., Rawlings-Rhea SD; Research Division, Seattle Children's Hospital, Seattle, Washington., Huang W; Research Division, Seattle Children's Hospital, Seattle, Washington., Pulsipher MA; Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California., Wayne AS; Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California., Park JR; Research Division, Seattle Children's Hospital, Seattle, Washington.; University of Washington, Department of Pediatrics, Seattle, Washington., Jensen MC; Research Division, Seattle Children's Hospital, Seattle, Washington.; University of Washington, Department of Pediatrics, Seattle, Washington.; Fred Hutchinson Cancer Research Center, Seattle, Washington., Gardner RA; Research Division, Seattle Children's Hospital, Seattle, Washington.; University of Washington, Department of Pediatrics, Seattle, Washington.

Publikováno v: Cancer immunology research [Cancer Immunol Res] 2022 Jul 01; Vol. 10 (7), pp. 856-870.