Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Kimiyasu, Shiraki"'
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e35331- (2024)
Reproductive toxicity is one of the major concerns in drug development. Thus, we have developed its screening system using Caenorhabditis elegans, which has a life cycle of three days and similar coding genes as humans. Antiviral nucleoside analogs u
Externí odkaz:
https://doaj.org/article/8cece8f302db486d8dfdea1dc7fa266c
Autor:
Tohru Daikoku, Mineyuki Mizuguchi, Takayuki Obita, Takeshi Yokoyama, Yoshihiro Yoshida, Masaya Takemoto, Kimiyasu Shiraki
Publikováno v:
Journal of Microbiology, Immunology and Infection, Vol 51, Iss 5, Pp 581-586 (2018)
Background: T-705 (favipiravir) is a potent inhibitor of RNA-dependent RNA polymerases of influenza viruses and no favipiravir-resistant virus has been isolated. Poliovirus RNA polymerase has been well characterized and isolation of resistant virus w
Externí odkaz:
https://doaj.org/article/fe371787875f47e6b9fb0c0dcb611317
Publikováno v:
Viruses, Vol 13, Iss 8, p 1547 (2021)
Acyclovir, valacyclovir, and famciclovir are used for the treatment of herpes simplex virus (HSV) and varicella-zoster virus (VZV) infections. Helicase-primase inhibitors (HPIs) inhibit replication fork progression that separates double DNA strands i
Externí odkaz:
https://doaj.org/article/7ac596772a52432e9501af3c04093aaf
Autor:
Noriaki Sato, Atsuko Shiraki, Keita P. Mori, Kaoru Sakai, Long Tan, Yoshinori Takemura, Yasushi Okuno, Kazunari Tanabe, Kimiyasu Shiraki
Publikováno v:
Antiviral research. 208
BK polyomavirus-associated nephropathy is one of serious complications in transplant recipients. Everolimus-a mammalian target of rapamycin inhibitor-has been shown to reduce the incidence of BK polyomavirus infection in transplant recipients. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d65739df4866f28a49e1fb8f2abe01
https://pubmed.ncbi.nlm.nih.gov/36328070
https://pubmed.ncbi.nlm.nih.gov/36328070
Publikováno v:
Journal of Pharmacological Sciences, Vol 126, Iss 3, Pp 281-284 (2014)
Abstract.: T-705 (favipiravir) is a potent inhibitor of RNA polymerases of influenza viruses. Susceptibility variants were isolated during passages in the presence of T-705. Nine variants with 0.4 to 2.1 times the 50% inhibitory concentration for pla
Externí odkaz:
https://doaj.org/article/54b82f1af69845c4a2a8577677ba76bc
Publikováno v:
Journal of Infection and Chemotherapy. 27:755-758
Varicella zoster virus (VZV) reactivates more frequently in immunocompromised patients than immunocompetent subjects and is a significant cause of morbidity and mortality. Acyclovir is frequently used for treatment against VZV reactivation. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ee4a31850910fe02e237d9646059b33
https://doi.org/10.1016/j.jiac.2020.12.013
https://doi.org/10.1016/j.jiac.2020.12.013
Emergence of varicella-zoster virus resistance to acyclovir: epidemiology, prevention, and treatment
Publikováno v:
Expert Review of Anti-infective Therapy. 19:1415-1425
Introduction: Acyclovir has led to the development of successful systemic therapy for herpes simplex virus and varicella-zoster virus (VZV) infection, and the use of valacyclovir and famciclovir ha...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f698d90497737d2ec8142a73661791b1
https://doi.org/10.1080/14787210.2021.1917992
https://doi.org/10.1080/14787210.2021.1917992
Publikováno v:
Case Reports in Ophthalmology, Vol 3, Iss 3, Pp 343-348 (2012)
Purpose: To report a case of varicella-zoster virus (VZV) keratitis with detection of VZV DNA in the tear fluid of not only the symptomatic eye but also the contralateral asymptomatic eye by polymerase chain reaction (PCR). Methods: This is a case re
Externí odkaz:
https://doaj.org/article/141cbab37d7a48b1959da891adb692d1
Autor:
Atsushi Sasaki, Kenichi Serizawa, Tsugunobu Andoh, Kimiyasu Shiraki, Hiroki Takahata, Yasushi Kuraishi
Publikováno v:
Journal of Pharmacological Sciences, Vol 108, Iss 3, Pp 266-273 (2008)
In the present study, we investigated whether dynamic and static allodynia would be developed in the affected dermatome in murine models of herpetic pain and postherpetic neuralgia and pharmacologically characterized the allodynia. Inoculation with h
Externí odkaz:
https://doaj.org/article/ae3a50d324ff416a9de79b034f31724a
Autor:
Ichiro Takasaki, Ryota Nagashima, Takahiro Ueda, Tomoki Ogata, Arata Inoue, Kimiyasu Shiraki, Yoshimi Kitada, Saori Arai
Publikováno v:
Biologicalpharmaceutical bulletin. 45(3)
In this study, we investigated the effects of fosphenytoin (fPHT), a water-soluble prodrug of phenytoin, on the pain responses of a mouse herpes zoster (HZ) pain model. Transdermal herpes simplex virus type 1 (HSV-1) inoculation induced mechanical al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d24639228b79bd1baac590faae51286
https://pubmed.ncbi.nlm.nih.gov/34937813
https://pubmed.ncbi.nlm.nih.gov/34937813