Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Kimio Tohyama"'
Autor:
Masako Sasaki, Ikuo Miyahisa, Sachiko Itono, Hiroaki Yashiro, Hideyuki Hiyoshi, Kazue Tsuchimori, Ken‐ichi Hamagami, Yusuke Moritoh, Masanori Watanabe, Kimio Tohyama, Minoru Sasaki, Jun‐ichi Sakamoto, Tomohiro Kawamoto
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 5, Pp n/a-n/a (2019)
Abstract Enteropeptidase, localized into the duodenum brush border, is a key enzyme catalyzing the conversion of pancreatic trypsinogen proenzyme to active trypsin, thereby regulating protein digestion and energy homeostasis. We report the discovery
Externí odkaz:
https://doaj.org/article/6a80d3a9b6c84d77bac6dd6c17560898
Autor:
Akina Harada, Kazunori Suzuki, Naomi Kamiguchi, Maki Miyamoto, Kimio Tohyama, Kosuke Nakashima, Takahiko Taniguchi, Haruhide Kimura
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122197 (2015)
Phosphodiesterase 10A (PDE10A) inhibition is a novel and promising approach for the treatment of central nervous system disorders such as schizophrenia and Huntington's disease. A novel PDE10A inhibitor, TAK-063 [1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl
Externí odkaz:
https://doaj.org/article/68f3374951714c6daf7aaec04f3b8474
Autor:
Zenichi Ikeda, Taku Kamei, Yusuke Sasaki, Matthew Reynolds, Nozomu Sakai, Masato Yoshikawa, Michiko Tawada, Nao Morishita, Douglas R. Dougan, Chien-Hung Chen, Irena Levin, Hua Zou, Masako Kuno, Naoto Arimura, Yusuke Kikukawa, Mitsuyo Kondo, Kimio Tohyama, Kenjiro Sato
Publikováno v:
Journal of Medicinal Chemistry. 66:6354-6371
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::079b3ce7aa41ba52a2e07271c1b47339
https://doi.org/10.1021/acs.jmedchem.3c00348
https://doi.org/10.1021/acs.jmedchem.3c00348
Autor:
Takashi Ishikawa, Hiroe Hara, Ayumi Kawano, Kimio Tohyama, Yuichi Kajita, Yuhei Miyanohana, Tatsuki Koike, Haruhide Kimura
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 385:193-204
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::943f5abc080d8723e72bbef696ad6f4a
https://doi.org/10.1124/jpet.122.001449
https://doi.org/10.1124/jpet.122.001449
Autor:
Paresh P. Chothe, Pallabi Mitra, Masanori Nakakariya, Diane Ramsden, Charles J. Rotter, Philip Sandoval, Kimio Tohyama
Publikováno v:
Drug Metabolism Reviews. 54:299-317
On behalf of the team I am pleased to present the second annual 'novel insights into drug transporter sciences review' focused on peer-reviewed articles that were published in the year 2021. In compiling the articles for inclusion, preprints availabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a028bb269c4a20a1ee02fa8fec23157
https://doi.org/10.1080/03602532.2022.2094944
https://doi.org/10.1080/03602532.2022.2094944
Publikováno v:
Drug Metabolism Reviews. 53:321-349
Drug Metabolism Reviews has an impressive track record of providing scientific reviews in the area of xenobiotic biotransformation over 47 years. It has consistently proved to be resourceful to many scientists from pharmaceutical industry, academia,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3e6b9b6b82d126ba3a0370336b2b06
https://doi.org/10.1080/03602532.2021.1963270
https://doi.org/10.1080/03602532.2021.1963270
Autor:
Zenichi Ikeda, Keiko Kakegawa, Fumiaki Kikuchi, Sachiko Itono, Hideyuki Oki, Hiroaki Yashiro, Hideyuki Hiyoshi, Kazue Tsuchimori, Kenichi Hamagami, Masanori Watanabe, Masako Sasaki, Youko Ishihara, Kimio Tohyama, Tomoyuki Kitazaki, Tsuyoshi Maekawa, Minoru Sasaki
Publikováno v:
Journal of medicinal chemistry. 65(12)
To discover a novel series of potent inhibitors of enteropeptidase, a membrane-bound serine protease localized to the duodenal brush border, 4-guanidinobenzoate derivatives were evaluated with minimal systemic exposure. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b02f0ea632ddd2d0cb7e6f020685b8b3
https://pubmed.ncbi.nlm.nih.gov/35686954
https://pubmed.ncbi.nlm.nih.gov/35686954
Autor:
Fumi Shimizu, Mitsugi Ookawara, Guido Hanauer, Kimio Tohyama, Masatoshi Hazama, Tomoya Sano, Yasunori Nio, Takanori Matsuo, Hisashi Anayama, Sachio Shibata, Midori Yamasaki
Publikováno v:
The FASEB Journal. 34:14997-15014
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease (ESRD). Hypertension increases kidney stress, which deteriorates function, and leads to peripheral renal vascular resistance. Long-term hypoperfusion promotes interstitial fibros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005f970e38618f971a9ead3d067aaa16
https://doi.org/10.1096/fj.202001084r
https://doi.org/10.1096/fj.202001084r
Publikováno v:
The AAPS Journal
Capturing unbound drug exposure in the brain is crucial to evaluate pharmacological effects for drugs acting on the central nervous system. However, to date, there are no reports of validated prediction models to determine the brain-to-plasma unbound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c665e7294e2eac54e172077ca4f96a
https://doi.org/10.1208/s12248-021-00609-6
https://doi.org/10.1208/s12248-021-00609-6
Autor:
Masatoshi Hazama, Kimio Tohyama, Takanori Matsuo, Kanako Kuniyeda, Yasunori Nio, Takako Naito, Sachio Shibata, Yo Muraki
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 83:1000-1010
Pulmonary hypertension (PH) is a life-threatening lung disease. PH with concomitant lung diseases, e.g., idiopathic pulmonary fibrosis, is associated with poor prognosis. Development of novel therapeutic vasodilators for treatment of these patients i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48807148c8db6761134e64b1b0f20b1
https://doi.org/10.1080/09168451.2019.1584520
https://doi.org/10.1080/09168451.2019.1584520