Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Kimio Higashiyama"'
Publikováno v:
Indonesian Journal of Chemistry, Vol 7, Iss 2, Pp 202-207 (2010)
Andrographolide, a diterpenoid lactone isolated from the herb of Andrographis paniculata and known to possess antitumor activity in breast cancer models was subjected to semisynthesis leading to the preparation of a number of derivatives. After prote
Externí odkaz:
https://doaj.org/article/bb27688147f74faf9eaa0979b3e39500
Autor:
Yoshiyuki Iwase, Takamichi Arima, Kanako Miyano, Michiko Narita, Minoru Narita, Yukari Suda, Naoko Kuzumaki, Shigeru Sasaki, Tomohisa Mori, Yusuke Hamada, Kazuyuki Sugita, Kimio Higashiyama, Shoki Matsumura, Yasuhito Uezono, Mitsuaki Yamazaki, Akinobu Matsuzawa, Takayasu Yamauchi, Yoshinori Takemura
Publikováno v:
Biochemical and Biophysical Research Communications. 534:988-994
TRV130 (oliceridine), a G protein-biased ligand for μ-opioid receptor, has recently been synthesized. It is considered to have strong antinociceptive effects and only minor adverse effects. However, whether or not oliceridine actually exhibits an id
Autor:
Kimio Higashiyama
Publikováno v:
YAKUGAKU ZASSHI. 140:273-287
Our investigations of various aspects of organic chemistry over the past 43 years are reviewed in this paper. The following subjects are discussed: 1) the diastereoselective addition reaction to chiral imines and oxazolidines of organometallic reagen
Autor:
Shigeru Sasaki, Natsuko Matsuo, Yuya Chikayuki, Hiroyoshi Teramoto, Kimio Higashiyama, Akiko Kirita, Takakane Miyashige, Shiori Yonekawa, Takayasu Yamauchi
Publikováno v:
Synthesis. 52:1113-1121
A transition-metal-free synthesis of pyridine derivatives by 6-endo-dig cyclization of N-propargyl enamines was developed. This method is environmentally friendly and is a high atom economy reaction that is easily accessed to provide pyridine derivat
Autor:
Eizoh Gondoh, Yusuke Hamada, Tomohisa Mori, Yusuke Iwazawa, Asami Shinohara, Michiko Narita, Daisuke Sato, Hiroyuki Tezuka, Takayasu Yamauchi, Mayu Tsujimura, Sara Yoshida, Kenichi Tanaka, Kensuke Yamashita, Haruka Akatori, Kimio Higashiyama, Kazuhiko Arakawa, Yukari Suda, Kanako Miyano, Masako Iseki, Eiichi Inada, Naoko Kuzumaki, Minoru Narita
Publikováno v:
British journal of cancer. 127(8)
It has been considered that activation of peripheral μ-opioid receptors (MORs) induces side effects of opioids. In this study, we investigated the possible improvement of the immune system in tumour-bearing mice by systemic administration of the per
Autor:
Shigenobu Toyota, Shigeru Sasaki, Toshihiro Uchiya, Takayasu Yamauchi, Hiroyoshi Teramoto, Tatuo Suzuki, Akira Hirano, Kimio Higashiyama, Mao Tanemura
Publikováno v:
Journal of Fluorine Chemistry. 192:78-85
We herein present an efficient method for the construction of α,α-difluoro-β-hydroxy ketones. The La(OTf)3-catalyzed aldol reaction between difluoroenol O-Boc (Boc = tert-butyloxycarbonyl) esters and carbonyl compounds affords α,α-difluoro-β-hy
Autor:
Seiji Shioda, Tomohisa Mori, Shigeto Hirayama, Kimio Higashiyama, Naoki Uzawa, Mayuna Hokazono, Tsutomu Suzuki, Mahardian Rahmadi, Yoshiyuki Iwase, Daiki Masukawa
Publikováno v:
Psychopharmacology. 233:2343-2353
Orexin knockout (KO) mice exhibit a phenotype that is similar to human narcolepsy, and monoamine-related compounds, such as psychostimulants and 5-HT uptake inhibitors, have been used for the treatment of narcoleptic disorders. However, little inform
Autor:
Yoko Waki, Yasuaki Kouno, Kimio Higashiyama, Haruka Ishikawa, Hiroyoshi Teramoto, Shiori Yonekawa, Takayasu Yamauchi, Shigeru Sasaki, Yuya Chikayuki
Publikováno v:
HETEROCYCLES. 100:719
Publikováno v:
Bulletin of the Chemical Society of Japan. 88:200-208
Bisoxazoline (BOX)-catalyzed asymmetric nucleophilic addition of diethyl zinc to fluorinated alkyl ketones successfully afforded enantioenriched fluorinated alkyl tertiary alcohols. The effect of t...
Autor:
Naoki Uzawa, Haruyo Kazawa, Masahiro Shibasaki, Ayano Mochizuki, Tomohisa Mori, Hirohiko Watanabe, Tsutomu Suzuki, Kazumi Yoshizawa, Kimio Higashiyama
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 350:403-411
Previous studies have demonstrated that methylphenidate, MDMA (3,4-methylenedioxymethamphetamine), and other psychostimulants exert stimulant-like subjective effects in humans. Furthermore, MDMA and methylphenidate substitute for the discriminative s