Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Kiminori Ohta"'
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1113 (2022)
Tamoxifen, a therapeutic agent for breast cancer, has been associated with genetic polymorphisms in the metabolism of N,N-dialkylaminoethyl substituent, which plays an important role in the expression of selective estrogen receptor modulator (SERM) a
Externí odkaz:
https://doaj.org/article/09e826a207ea4acab0e61436f07f7b5d
Publikováno v:
Molecules, Vol 24, Iss 21, p 3966 (2019)
Based upon hydrophobic feedback approaches, we designed and synthesized novel sulfur-containing ERα modulators (4 and 5) as breast cancer therapeutic drug candidates. The tetrahydrothiepine derivative 5a showed the highest binding affinity toward ER
Externí odkaz:
https://doaj.org/article/a8eddd8285544818a8d04e429bfae35b
Autor:
Aleksandra Jankowiak, Piotr Kaszynski, William R. Tilford, Kiminori Ohta, Adam Januszko, Takashi Nagamine, Yasuyuki Endo
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 5, Iss 1, p 83 (2009)
The effect of the phenyl–alkyl connecting group on mesogenic properties of several series of isostructural compounds containing p-carborane (A and B), bicyclo[2.2.2]octane (C), and benzene (D) was investigated using thermal and optical methods. Res
Externí odkaz:
https://doaj.org/article/2de6e12cd5e8422b815bb02df5159498
Autor:
Kiminori Ohta
Publikováno v:
YAKUGAKU ZASSHI. 143:421-428
Autor:
Kiminori Ohta, Shinya Fujii
Publikováno v:
YAKUGAKU ZASSHI. 143:419-420
Autor:
Hiroki Inoue, Koichi Kato, Akifumi Oda, Tomoki Nakayoshi, Yasuyuki Endo, Kiminori Ohta, Shuichi Fukuyoshi, Eiji Kurimoto
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1931-1939
Androgen receptor (AR) has a key role in the development and progression of prostate cancer, and AR antagonists are used for its remedy. Recently, carborane derivatives, which are carbon-containing boron clusters have attracted attention as new AR li
Autor:
Shinya Fujii, Kiminori Ohta
Publikováno v:
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 142(2)
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1113
International Journal of Molecular Sciences, Vol 23, Iss 1113, p 1113 (2022)
International Journal of Molecular Sciences, Vol 23, Iss 1113, p 1113 (2022)
Tamoxifen, a therapeutic agent for breast cancer, has been associated with genetic polymorphisms in the metabolism of N,N-dialkylaminoethyl substituent, which plays an important role in the expression of selective estrogen receptor modulator (SERM) a
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2290-2293
Estrogen receptor (ER) exhibits two subtypes, ERα and ERβ, whose biological functions are quite different despite expression in the same tissues. We developed diiodo-m-carborane derivative 3a, which showed 14-fold selectivity for ERβ with high bin
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:3805-3811
Based on the co-crystal structure of bicalutamide with a T877A-mutated androgen receptor (AR), glycerol and aminoglycerol derivatives were designed and synthesized as a novel type of carborane-containing AR modulators. The (R)-isomer of 6c, whose chi