Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Kiminori, Nakamura"'
Autor:
Yu Shimizu, Ryodai Yamamura, Yuki Yokoi, Tokiyoshi Ayabe, Shigekazu Ukawa, Koshi Nakamura, Emiko Okada, Akihiro Imae, Takafumi Nakagawa, Akiko Tamakoshi, Kiminori Nakamura
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTSleep is essential for our health. Short sleep is known to increase disease risks via imbalance of intestinal microbiota, dysbiosis. However, mechanisms by which short sleep induces dysbiosis remain unknown. Small intestinal Paneth cell regul
Externí odkaz:
https://doaj.org/article/c1d587c55f914288bff8faa9a0cab49a
Autor:
Shunta Nakamura, Kiminori Nakamura, Yuki Yokoi, Yu Shimizu, Shuya Ohira, Mizu Hagiwara, Zihao Song, Li Gan, Tomoyasu Aizawa, Daigo Hashimoto, Takanori Teshima, Andre J. Ouellette, Tokiyoshi Ayabe
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Nonalcoholic steatohepatitis (NASH) is a chronic liver disease characterized by fibrosis that develops from fatty liver. Disruption of intestinal microbiota homeostasis, dysbiosis, is associated with fibrosis development in NASH. An antimicr
Externí odkaz:
https://doaj.org/article/ad3288f42a2948a6ac84fd4142d11a39
Autor:
Yuchi Song, Yi Wang, Shaonan Yan, Kiminori Nakamura, Takashi Kikukawa, Tokiyoshi Ayabe, Tomoyasu Aizawa
Publikováno v:
Microbial Cell Factories, Vol 22, Iss 1, Pp 1-15 (2023)
Abstract Background A number of antimicrobial peptides (AMPs) hold promise as new drugs owing to their potent bactericidal activity and because they are often refractory to the development of drug resistance. Cryptdins (Crps) are a family of antimicr
Externí odkaz:
https://doaj.org/article/62d435e515d94e13bfa76953ca530e3b
Autor:
Li Gan, Yuga Inamura, Yu Shimizu, Yuki Yokoi, Yuki Ohnishi, Zihao Song, Yasuhiro Kumaki, Takashi Kikukawa, Makoto Demura, Masaaki Ito, Tokiyoshi Ayabe, Kiminori Nakamura, Tomoyasu Aizawa
Publikováno v:
Metabolites, Vol 13, Iss 9, p 1003 (2023)
Mulberry leaves contain α-glucosidase inhibitors, which have hypoglycemic effects and are considered functional foods. However, few reports have covered the effects of mulberry leaf components on normal gut microbiota and gut metabolites. Herein, gu
Externí odkaz:
https://doaj.org/article/abbc900fc6d44e74bd6a5a92d2589660
Autor:
Yi Wang, Yuchi Song, Shaonan Yan, Rina Hiramine, Yuki Ohnishi, Yuki Yokoi, Kiminori Nakamura, Takashi Kikukawa, Tokiyoshi Ayabe, Tomoyasu Aizawa
Publikováno v:
Antibiotics, Vol 12, Iss 6, p 1047 (2023)
Cryptdin-4 (crp4) is an enteric α-defensin derived from mice, and is a main mediator of immunity to oral infections and a determinant of the composition of the intestinal microbiota. Structurally, crp4 exists in two states: the oxidized form (crp4ox
Externí odkaz:
https://doaj.org/article/c23ba41ce7224358868d85d87181e985
Autor:
Kosuke Suzuki, Kiminori Nakamura, Yu Shimizu, Yuki Yokoi, Shuya Ohira, Mizu Hagiwara, Yi Wang, Yuchi Song, Tomoyasu Aizawa, Tokiyoshi Ayabe
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Psychological stress has been reported to relate to dysbiosis, imbalance of the intestinal microbiota composition, and contribute to the onset and exacerbation of depression, though, underlying mechanisms of psychological stress-related dysb
Externí odkaz:
https://doaj.org/article/7a71c12027b64439b42c83c6fb53d9e9
Autor:
Zihao Song, Yuki Ohnishi, Seiji Osada, Li Gan, Jiaxi Jiang, Zhiyan Hu, Hiroyuki Kumeta, Yasuhiro Kumaki, Yuki Yokoi, Kiminori Nakamura, Tokiyoshi Ayabe, Kazuo Yamauchi, Tomoyasu Aizawa
Publikováno v:
Metabolites, Vol 13, Iss 5, p 611 (2023)
Nuclear magnetic resonance (NMR)-based metabolomics, which comprehensively measures metabolites in biological systems and investigates their response to various perturbations, is widely used in research to identify biomarkers and investigate the path
Externí odkaz:
https://doaj.org/article/bf624b2ec55645f683f74859aa234358
Autor:
Kunihiko Kotake, Toshihiko Kumazawa, Kiminori Nakamura, Yu Shimizu, Tokiyoshi Ayabe, Takahiro Adachi
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
In Japan, there is a long history of consumption of miso, a fermented soybean paste, which possesses beneficial effects on human health. However, the mechanism behind these effects is not fully understood. To clarify the effects of miso on immune cel
Externí odkaz:
https://doaj.org/article/479f4ee0ecc5416aa9842349038620cc
Autor:
Yosuke Komatsu, Yasuaki Wada, Fuka Tabata, Satomi Kawakami, Yasuhiro Takeda, Kiminori Nakamura, Tokiyoshi Ayabe, Koshi Nakamura, Takashi Kimura, Akiko Tamakoshi
Publikováno v:
Nutrients, Vol 15, Iss 3, p 654 (2023)
Maternal diet may affect human milk macronutrients, but it remains to be elucidated whether this is also influential in infant growth. This study aimed to examine (1) how maternal diet influences human milk macronutrients, and (2) to what extent the
Externí odkaz:
https://doaj.org/article/bdb52db53c174e06aa8f5aa568c3c470
Autor:
Kiminori Nakamura, Yuki Yokoi, Rie Fukaya, Shuya Ohira, Ryuga Shinozaki, Takuto Nishida, Mani Kikuchi, Tokiyoshi Ayabe
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Paneth cells contribute to intestinal innate immunity by sensing bacteria and secreting α-defensin. In Institute of Cancer Research (ICR) mice, α-defensin termed cryptdin (Crp) in Paneth cells consists of six major isoforms, Crp1 to 6. Despite accu
Externí odkaz:
https://doaj.org/article/ed96f2d99059439ba1df48b709a46d30