Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Kimiko Konishi"'
Autor:
Koji Hori, Kimiko Konishi, Misa Hosoi, Hiroi Tomioka, Masayuki Tani, Yuka Kitajima, Mitsugu Hachisu
Publikováno v:
Parkinson's Disease, Vol 2016 (2016)
Given the relationship between anticholinergic activity (AA) and Alzheimer’s disease (AD), we rereview our hypothesis of the endogenous appearance of AA in AD. Briefly, because acetylcholine (ACh) regulates not only cognitive function but also the
Externí odkaz:
https://doaj.org/article/497ae35370a048cda2a446544b5b307e
Autor:
Kimiko Konishi, Michiho Sodenaga, Chaiki Hashimoto, Koji Hori, Kyoko Katsumura, Mitsugu Hachisu
Publikováno v:
Journal of Alzheimer’s Disease & Parkinsonism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f77df963652786360156bb570c89ed1
https://doi.org/10.4172/2161-0460.1000449
https://doi.org/10.4172/2161-0460.1000449
Autor:
Akihito Hirata, Kimiko Konishi, Yuka Kitajima, Taishi Koganemaru, Atsuko Inamoto, Norihisa Akashi, Akari Takahashi, Masayuki Tani, Koji Hori, Hiroi Tomioka, Akisa Tomita, Mitsugu Hachisu
Publikováno v:
Neurodegenerative Diseases. 15:168-174
In this article, we review the downregulation of acetylcholinergic activity in schizophrenia and discuss the similarity and difference between Alzheimer's disease (AD) and schizophrenia in terms of acetylcholine (ACh) and anticholinergic activity (AA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc05769122fe3f78aa2e519fb077824
https://doi.org/10.1159/000381523
https://doi.org/10.1159/000381523
Autor:
Masayuki Tani, Sousuke Minami, Kimiko Konishi, Atsuko Inamoto, Takuji Izuno, Kentaro Horiuchi, Mitsugu Hachisu, Koji Hori, Misa Hosoi, Hiroi Tomioka, Kaori Umezawa
Publikováno v:
Neurodegenerative Diseases. 15:182-187
The brain of Alzheimer's disease (AD) patients is characterized by neurodegeneration, especially an acetylcholine (ACh) neuronal deficit with accumulation of β-amyloid protein, which leads to oxygen stress and inflammation. The active oxygen directl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796a8da8417469e1ccca9c284b9a156c
https://doi.org/10.1159/000381531
https://doi.org/10.1159/000381531
Autor:
Kimiko Konishi, Hiroi Tomioka, Mitsugu Hachisu, Koji Hori, Sayaka Hasegawa, Akari Takahashi, Nodoka Kikuchi, Misa Hosoi, Norihisa Akashi, Atsuko Inamoto, Masayuki Tani, Yuka Kitajima
Publikováno v:
Neurodegenerative Diseases. 15:162-167
We have previously proposed a hypothesis in which we argue that anticholinergic activity (AA) appears endogenously in Alzheimer's disease (AD). Acetylcholine (ACh) controls both cognitive function and inflammation. Consequently, when the downregulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2a32c00db5fc43baa0f41b986ebd91
https://doi.org/10.1159/000381522
https://doi.org/10.1159/000381522
Association Between Serum Anticholinergic Activity and Psychiatric Symptoms of Chronic Schizophrenia
Autor:
Kimiko Konishi, Akira Iwanami, Norihisa Akashi, Koji Hori, Masayuki Tani, Misa Hosoi, Mitsugu Hachisu, Nobumasa Kato, Takahiro Tokumasu
Publikováno v:
The Showa University Journal of Medical Sciences. 27:251-260
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60869150cdd74615eb6df88c4c6bffd1
https://doi.org/10.15369/sujms.27.251
https://doi.org/10.15369/sujms.27.251
Autor:
Koji Hori, Kimiko Konishi, Haijime Yuda, Atsuko Inamoto, Norihisa Akashi, Yuka Kitajima, Misa Hosoi, Takahiro Hanashi, Hiroi Tomioka, Hiromi Ouchi, Masayuki Tani, Mitsugu Hachisu, Kenzo Kurosawa
Publikováno v:
Neurodegenerative Diseases. 15:149-156
In this article, we review and repropose our hypothesis of the endogenous appearance of anticholinergic activity (AA) in Alzheimer's disease (AD). First, we introduce our previous articles and speculate that, because acetylcholine (ACh) regulates bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34984f417262360854e3fa6f9441f57c
https://doi.org/10.1159/000381511
https://doi.org/10.1159/000381511
Autor:
Kimiko Konishi, Misa Hosoi, Mitsugu Hachisu, Hiroi Tomioka, Hiroyuki Kamatani, Michiho Sodenaga, Koji Hori
Publikováno v:
Journal of Alzheimer’s Disease & Parkinsonism.
We encountered a 79 year old female patient with mild cognitive impairment who showed sustained improvement to an almost normal level of global cognitive function for >1 year when treated with donepezil. Her levels of high-sensitivity C-reactive prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54e06492c65013df6e0098978cbd0d4e
https://doi.org/10.4172/2161-0460.1000402
https://doi.org/10.4172/2161-0460.1000402
Autor:
Kimiko Konishi, Taisuke Murakami, Eiichi Inada, Isao Nagaoka, Mitsugu Hachisu, Atsuko Hara, Koji Hori, Yoshiaki Kajiyama, Akimasa Someya, Yuka Kitajima, Keisuke Yamaguchi
Publikováno v:
Juntendo Medical Journal. 60:147-150
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::636450d2ee7dc76c71272181c5dc5415
https://doi.org/10.14789/jmj.60.147
https://doi.org/10.14789/jmj.60.147
Publikováno v:
Neurodegenerative Diseases. 15:131-133
AA cascade in AD’ or ‘progression of AD by its own mechanism’. Although there are AA-inducing factors other than downregulation of ACh (e.g. drugs, febrile illness or mental stress), upregulation of ACh is possible if the ACh system is not depr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4d679a00147356a3280e322a6a1af1f
https://doi.org/10.1159/000381482
https://doi.org/10.1159/000381482