Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

Autor: Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, Mikio Hoshino, Akito Nakao, Yasuo Mori, Shigeo Okabe, Masayuki Matsushita, Anja Urbach, Yuta Katayama, Akinobu Matsumoto, Keiichi I Nakayama, Shota Katori, Takuya Sato, Takuji Iwasato, Haruko Nakamura, Yoshio Goshima, Matthieu Raveau, Tetsuya Tatsukawa, Kazuhiro Yamakawa, Noriko Takahashi, Haruo Kasai, Johji Inazawa, Ikuo Nobuhisa, Tetsushi Kagawa, Tetsuya Taga, Mohamed Darwish, Hirofumi Nishizono, Keizo Takao, Kiran Sapkota, Kazutoshi Nakazawa, Tsuyoshi Takagi, Haruki Fujisawa, Yoshihisa Sugimura, Kyosuke Yamanishi, Lakshmi Rajagopal, Nanette Deneen Hannah, Herbert Y Meltzer, Tohru Yamamoto, Shuji Wakatsuki, Toshiyuki Araki, Katsuhiko Tabuchi, Tadahiro Numakawa, Hiroshi Kunugi, Freesia L Huang, Atsuko Hayata-Takano, Hitoshi Hashimoto, Kota Tamada, Toru Takumi, Takaoki Kasahara, Tadafumi Kato, Isabella A Graef, Gerald R Crabtree, Nozomi Asaoka, Hikari Hatakama, Shuji Kaneko, Takao Kohno, Mitsuharu Hattori, Yoshio Hoshiba, Ryuhei Miyake, Kisho Obi-Nagata, Akiko Hayashi-Takagi, Léa J Becker, Ipek Yalcin, Yoko Hagino, Hiroko Kotajima-Murakami, Yuki Moriya, Kazutaka Ikeda, Hyopil Kim, Bong-Kiun Kaang, Hikari Otabi, Yuta Yoshida, Atsushi Toyoda, Noboru H Komiyama, Seth GN Grant, Michiru Ida-Eto, Masaaki Narita, Ken-ichi Matsumoto, Emiko Okuda-Ashitaka, Iori Ohmori, Tadayuki Shimada, Kanato Yamagata, Hiroshi Ageta, Kunihiro Tsuchida, Kaoru Inokuchi, Takayuki Sassa, Akio Kihara, Motoaki Fukasawa, Nobuteru Usuda, Tayo Katano, Teruyuki Tanaka, Yoshihiro Yoshihara, Michihiro Igarashi, Takashi Hayashi, Kaori Ishikawa, Satoshi Yamamoto, Naoya Nishimura, Kazuto Nakada, Shinji Hirotsune, Kiyoshi Egawa, Kazuma Higashisaka, Yasuo Tsutsumi, Shoko Nishihara, Noriyuki Sugo, Takeshi Yagi, Naoto Ueno, Tomomi Yamamoto, Yoshihiro Kubo, Rie Ohashi, Nobuyuki Shiina, Kimiko Shimizu, Sayaka Higo-Yamamoto, Katsutaka Oishi, Hisashi Mori, Tamio Furuse, Masaru Tamura, Hisashi Shirakawa, Daiki X Sato, Yukiko U Inoue, Takayoshi Inoue, Yuriko Komine, Tetsuo Yamamori, Kenji Sakimura, Tsuyoshi Miyakawa

Publikováno v: eLife, Vol 12 (2024)

Increased levels of lactate, an end-product of glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These changes in lactate levels can result in decreased brain pH, which has been implicate

Externí odkaz: https://doaj.org/article/15de117935204a21a8487997042e8094

The circadian clock in the piriform cortex intrinsically tunes daily changes of odor-evoked neural activity

Autor: Shunsuke Takeuchi, Kimiko Shimizu, Yoshitaka Fukada, Kazuo Emoto

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)

Loss of the clock gene, Bmal1, in the piriform cortex largely abolishes the circadian rhythm of odor-evoked activity in mice, suggesting a broader regulatory role for Bmal1 in olfactory neural activity and transmission.

Externí odkaz: https://doaj.org/article/f3bf1db0122c494f952f47ac6a051078

DIURNAL RHYTHM OF LEARNING AND MEMORY REGULATED BY SCOP IN MICE AND NONHUMAN PRIMATES

Autor: Kimiko Shimizu, Ken-Ichi Inoue, Takao Oishi, Hiroo Imai, Masahiko Takada, Yoshitaka Fukada

Publikováno v: IBRO Neuroscience Reports, Vol 15, Iss , Pp S896- (2023)

Externí odkaz: https://doaj.org/article/34bc63068871449aad23b40e21338d3f

Lithium ion adduction enables UPLC-MS/MS-based analysis of multi-class 3-hydroxyl group-containing keto-steroids[S]

Autor: Qiuyi Wang, Kimiko Shimizu, Kanako Maehata, Yue Pan, Koki Sakurai, Takatoshi Hikida, Yoshitaka Fukada, Toshifumi Takao

Publikováno v: Journal of Lipid Research, Vol 61, Iss 4, Pp 570-579 (2020)

Steroids that contain a 3-hydroxyl group (3-OH steroids) are widely distributed in nature. During analysis with ESI-MS, they easily become dehydrated while in the protonated form, resulting in the production of several precursor ions and leading to l

Externí odkaz: https://doaj.org/article/ee04f03d5d7343238a62d6f7fd8289c6

The Japanese version of the questionnaire about the process of recovery: development and validity and reliability testing

Autor: Akiko Kanehara, Risa Kotake, Yuki Miyamoto, Yousuke Kumakura, Kentaro Morita, Tomoko Ishiura, Kimiko Shimizu, Yumiko Fujieda, Shuntaro Ando, Shinsuke Kondo, Kiyoto Kasai

Publikováno v: BMC Psychiatry, Vol 17, Iss 1, Pp 1-11 (2017)

Abstract Background Personal recovery is increasingly recognised as an important outcome measure in mental health services. This study aimed to develop a Japanese version of the Questionnaire about the Process of Recovery (QPR-J) and test its validit

Externí odkaz: https://doaj.org/article/badca90ecfbb4a6bb3b5d7a267d672eb