Výsledky vyhledávání - "Kimihisa Ueno"

Akademický článek

Effects of Combination Treatment With Dipeptidyl Peptidase IV Inhibitor and Sulfonylurea on Glucose Levels in Rats

Autor: Kotaro Takasaki, Takao Nakajima, Kimihisa Ueno, Yuji Nomoto, Katsuya Higo

Publikováno v: Journal of Pharmacological Sciences, Vol 95, Iss 2, Pp 291-293 (2004)

The effects of orally administered dipeptidyl peptidase IV (DPP-IV) inhibitor on the glucose-lowering effect of glibenclamide are still unknown. We evaluated the effects of combination treatment with a long-lasting DPP-IV inhibitor, K579 ((S)-1-[4-me

Externí odkaz: https://doaj.org/article/41150b8b1a8d49f985158020929e1473

Zobrazit plný text záznamu

Development of Dihydrodibenzooxepine Peroxisome Proliferator-Activated Receptor (PPAR) Gamma Ligands of a Novel Binding Mode as Anticancer Agents: Effective Mimicry of Chiral Structures by Olefinic E/Z-Isomers

Autor: Yuichi Takahashi, Satoshi Shuto, Jun-Ichi Saito, Kimihisa Ueno, Tomohiro Tamura, Michihiko Suzuki, Kazuki Henmi, Masahiro Matsubara, Takeshi Kuboyama, Yamamoto Keisuke, Arata Yanagisawa

Publikováno v: Journal of Medicinal Chemistry. 61:10067-10083

A novel class of PPARγ ligand 1 (EC50 = 197 nM) with a dibenzoazepin scaffold was identified through high-throughput screening campaign. To avoid the synthetically troublesome chiral center of 1, its conformational analysis using the MacroModel was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce88365240ca4ee46874f01676f40c25
https://doi.org/10.1021/acs.jmedchem.8b01200

Zobrazit plný text záznamu

Development of a novel class of peroxisome proliferator-activated receptor (PPAR) gamma ligands as an anticancer agent with a unique binding mode based on a non-thiazolidinedione scaffold

Autor: Shintaro Hosoe, Hiroshi Kodaira, Masahiro Matsubara, Jun-Ichi Saito, Kimihisa Ueno, Takeshi Uemori, Yuichi Takahashi, Tomohiro Tamura, Keiko Nagata, Yamamoto Keisuke, Michihiko Suzuki, Nakamura Rina, Satoshi Shuto

Publikováno v: Bioorganic & Medicinal Chemistry / Bioorganic and Medicinal Chemistry. 27(22):115122

We previously identified dibenzooxepine derivative 1 as a potent PPARγ ligand with a unique binding mode owing to its non-thiazolidinedione scaffold. However, while 1 showed remarkably potent MKN-45 gastric cancer cell aggregation activity, an indic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9745266e23aa35ca0ee84694ed58b04c
http://hdl.handle.net/2115/83295

Zobrazit plný text záznamu

Inhibitory Effect of the 4-Aminotetrahydroquinoline Derivatives, Selective Chemoattractant Receptor-Homologous Molecule Expressed on T Helper 2 Cell Antagonists, on Eosinophil Migration Induced by Prostaglandin D2

Autor: Etsuo Ohshima, Hiromasa Miyaji, Hideki Mimura, Toshihide Ikemura, Akira Karasawa, Haruhiko Manabe, Masatsugu Sawada, Eiichi Fuse, Kimihisa Ueno, Osamu Kotera, Satoshi Tashiro

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 314:244-251

Prostaglandin (PG) D2, a major cyclooxygenase metabolite generated from immunologically stimulated mast cells, is known to induce activation and chemotaxis in eosinophils, basophils, and T helper 2 (Th2) lymphocytes via a newly identified PGD2 recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60df708eba40cad01479b1708db65ef
https://doi.org/10.1124/jpet.104.081539

Zobrazit plný text záznamu

K579, a slow-binding inhibitor of dipeptidyl peptidase IV, is a long-acting hypoglycemic agent

Autor: Kimihisa Ueno, Takao Nakajima, Satoshi Nakanishi, Kotaro Takasaki, Katsuya Higo, Miho Iwase, Yuji Nomoto

Publikováno v: European Journal of Pharmacology. 486:335-342

Dipeptidyl peptidase IV inhibitors are expected to be categorized in a new type of antidiabetic drugs. We had developed a long-acting dipeptidyl peptidase IV inhibitor, K579 [(S)-1-[4-methyl-1-(2-pyrimidinyl)-4-piperidylamino]acetyl-2-pyrrolidinecarb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2ea59761020bf226e9774c65a956bb
https://doi.org/10.1016/j.ejphar.2003.12.029

Zobrazit plný text záznamu

Synthesis of an Ethyl 6-Amino-3,5-difluorosalicylate Derivative by Sequential Regioselective Directed ortho-Metalation; A Practical Synthesis of4',5-Diamino-3',6,8-trifluoroflavone, A Potent Antitumor Agent

Autor: Tsutomu Akama, Hiromitsu Saito, Masaji Kasai, Kimihisa Ueno

Publikováno v: Synthesis. 1997:1446-1450

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::944c3992d887d4e06c863cdb7d6dda1b
https://doi.org/10.1055/s-1997-1379

Zobrazit plný text záznamu

Effects of Combination Treatment With Dipeptidyl Peptidase IV Inhibitor and Sulfonylurea on Glucose Levels in Rats

Autor: Katsuya Higo, Takao Nakajima, Kotaro Takasaki, Kimihisa Ueno, Yuji Nomoto

Publikováno v: Journal of Pharmacological Sciences, Vol 95, Iss 2, Pp 291-293 (2004)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621c5c2031c3eec0a072050a94f20a72
http://www.sciencedirect.com/science/article/pii/S134786131932448X

Zobrazit plný text záznamu

Involvement of the active metabolites in the inhibitory activity of K579 on rat plasma dipeptidyl peptidase IV

Autor: Takao Nakajima, Katsuya Higo, Kotaro Takasaki, Kimihisa Ueno, Junko Ushiki, Hidenori Takada

Publikováno v: European journal of pharmacology. 505(1-3)

K579 ((S)-1-[4-methyl-1-(2-pyrimidinyl)-4-piperidylamino]acetyl-2-pyrrolidinecarbonitrile), which is a long-acting and a slow binding dipeptidyl peptidase IV inhibitor, preserved the endogenously secreted active forms of glucagon-like peptide-1, augm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad2ed4e5628ea5b5a2cc5163fad9f6c
https://pubmed.ncbi.nlm.nih.gov/15556158

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání