Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kimberly Siegmund"'
Autor:
Chun R. Chao, Jeff Slezak, Kimberly Siegmund, Kimberly Cannavale, Yu‐Hsiang Shu, Gary W. Chien, Xu‐Feng Chen, Feng Shi, Nan Song, Stephen K. Van Den Eeden, Jiaoti Huang
Publikováno v:
Cancer Medicine, Vol 12, Iss 18, Pp 18837-18849 (2023)
Abstract Background We used a genome‐wide discovery approach to identify methylation markers associated with metastasis in men with localized prostate cancer (PCa), as better identification of those at high risk of metastasis can inform treatment d
Externí odkaz:
https://doaj.org/article/7e2cb60011cb4623851ef31c8c7570c4
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0253250 (2021)
Recent DepMap CRISPR-Cas9 single gene disruptions have identified genes more essential to proliferation in tissue culture. It would be valuable to translate these finding with measurements more practical for human tissues. Here we show that DepMap es
Externí odkaz:
https://doaj.org/article/dd5e8a0b733444d29d5c1894c5fc6331
Autor:
Sungshim L. Park, Yesha M. Patel, Lenora W. M. Loo, Daniel J. Mullen, Ite A. Offringa, Alika Maunakea, Daniel O. Stram, Kimberly Siegmund, Sharon E. Murphy, Maarit Tiirikainen, Loïc Le Marchand
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-12 (2018)
Abstract Background Lung cancer is the leading cause of cancer-related death. While cigarette smoking is the primary cause of this malignancy, risk differs across racial/ethnic groups. For the same number of cigarettes smoked, Native Hawaiians compar
Externí odkaz:
https://doaj.org/article/67c88d458b6545b0886b02eff2c43a85
Autor:
Fayth L. Miles, Andrew Mashchak, Valery Filippov, Michael J. Orlich, Penelope Duerksen-Hughes, Xin Chen, Charles Wang, Kimberly Siegmund, Gary E. Fraser
Publikováno v:
Nutrients, Vol 12, Iss 12, p 3697 (2020)
We sought to determine if DNA methylation patterns differed between vegans and non-vegetarians in the Adventist Health Study-2 cohort. Genome-wide DNA methylation derived from buffy coat was profiled in 62 vegans and 142 non-vegetarians. Using linear
Externí odkaz:
https://doaj.org/article/85206c78ece34d44b8b7c0ab86a2c92a
Autor:
Junsong Zhao, Matthew P Salomon, Darryl Shibata, Christina Curtis, Kimberly Siegmund, Paul Marjoram
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172516 (2017)
Tumor growth is an evolutionary process involving accumulation of mutations, copy number alterations, and cancer stem cell (CSC) division and differentiation. As direct observation of this process is impossible, inference regarding when mutations occ
Externí odkaz:
https://doaj.org/article/3a4361391d5c4e268ada795df96b81c2
Autor:
Sahar Houshdaran, Victoria K Cortessis, Kimberly Siegmund, Allen Yang, Peter W Laird, Rebecca Z Sokol
Publikováno v:
PLoS ONE, Vol 2, Iss 12, p e1289 (2007)
BackgroundMale-factor infertility is a common condition, and etiology is unknown for a high proportion of cases. Abnormal epigenetic programming of the germline is proposed as a possible mechanism compromising spermatogenesis of some men currently di
Externí odkaz:
https://doaj.org/article/22c4699e7dba4875bc2049af3e3c75a2
Plasticity, or the ability to rapidly and reversibly change phenotypes, may help explain how a single progenitor cell eventually generates a tumor with many different cell phenotypes. We developed a quantitative signal of plasticity that correlates e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e05f79d8e99b6968ef133350510b6849
https://doi.org/10.21203/rs.3.rs-2609517/v1
https://doi.org/10.21203/rs.3.rs-2609517/v1
Autor:
YI-TSUNG LU, Gerald Gooden, Ben Y. Tew, David Buckley, Kimberly Siegmund, Siamak Daneshmand, Amir Goldkorn, Bodour Salhia
Publikováno v:
Cancer Research. 79:2274-2274
Background: Muscle invasive bladder cancer (MIBC) is a lethal disease with high recurrence rate despite standard radical cystectomy with neoadjuvant chemotherapy. Informative new biomarker strategies are needed to accurately assess the risk of recurr
Autor:
Haeyoun, Kang, Matthew P, Salomon, Andrea, Sottoriva, Junsong, Zhao, Morgan, Toy, Michael F, Press, Christina, Curtis, Paul, Marjoram, Kimberly, Siegmund, Darryl, Shibata
Publikováno v:
The Journal of pathology. 237(3)
Intratumoural mutational heterogeneity (ITH) or the presence of different private mutations in different parts of the same tumour is commonly observed in human tumours. The mechanisms generating such ITH are uncertain. Here we find that ITH can be re