Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Kimberly S. Fuson"'
Autor:
E. J. Holsztynska, K. L. Sacchi, L. Z. Chen, J. C. Clemens, I. M. Lieberburg, L. C. Mutter, Bruce D. Gitter, T. C. Britton, C. A. Whitesitt, E. D. Thorsett, L. D. Altstiel, M. H. Bender, K. L. Johnson-Wood, G. M. Shopp, R. N. Motter, B. Folmer, T. E. Mabry, D. Stephenson, S. Yang, B. D. Potts, Binhui Ni, D. B. Schenk, T. Yin, Paul A. Hyslop, Jon K. Reel, K. L. Hu, W.-Y. Li, C. T. Yin, J. E. Knops, P. De Saint Andrieu, V. John, Z. Liao, E. Goldbach, F. D. Miller, L. A. Shipley, J. Wu, E. M. Johnstone, L. H. Latimer, S. B. Freedman, J. P. Anderson, H. F. Dovey, P. A. Seubert, Michael K. Lee, D. K. Dieckman-Mcginty, S. L. Kennedy, J. S. Nissen, Sheila P. Little, Leonard N. Boggs, J. S. Tung, J. Nietz, L. Y. Fang, D. L. Czilli, Patrick C. May, Warren J. Porter, James E. Audia, K. P. Quinn, J. J. Droste, D. Kholodenko, Y. Su, Kimberly S. Fuson
Publikováno v:
Journal of Neurochemistry. 76:173-181
Converging lines of evidence implicate the beta-amyloid peptide (Ass) as causative in Alzheimer's disease. We describe a novel class of compounds that reduce A beta production by functionally inhibiting gamma-secretase, the activity responsible for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::630a5e68d7d06683f0b9a3afbc3d4a0e
https://doi.org/10.1046/j.1471-4159.2001.00012.x
https://doi.org/10.1046/j.1471-4159.2001.00012.x
Publikováno v:
Journal of Neurochemistry. 72:1154-1160
The compound LY231617 {2,6-bis(1,1 -dimethylethyl)-4-[[(1-ethyl)amino]methyl]phenol hydrochloride) has been reported to afford significant neuroprotection against hydrogen peroxide (H 2 O 2 )-induced toxicity in vitro and global ischemia in vivo. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024ceaf43385d590a8520321c708fae3
https://doi.org/10.1046/j.1471-4159.1999.0721154.x
https://doi.org/10.1046/j.1471-4159.1999.0721154.x
Publikováno v:
Journal of Neurochemistry. 72:1146-1153
The amyloid beta-peptide (A beta) is a major component of the neuritic plaques that are a defining histological characteristic of Alzheimer's disease. A beta can be directly toxic and pro-inflammatory to cells in vitro. Numerous reports have shown th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e830c9d9eaaf44cf649c0ccfee1ac8b
https://doi.org/10.1046/j.1471-4159.1999.0721146.x
https://doi.org/10.1046/j.1471-4159.1999.0721146.x
Autor:
Gary J. Drzewiecki, Zhiyuan Zhang, James E. Audia, Patrick C. May, Russell E. Rydel, Mark Wogulis, Sarah Wright, Paul A. Hyslop, Kimberly S. Fuson
Publikováno v:
Journal of Neurochemistry. 67:1595-1606
H2O2 and free radical-mediated oxidative stresses have been implicated in mediating amyloid beta (1-40) [A beta (1-40)] neurotoxicity to cultured neurons. In this study, we confirm that addition of the H2O2-scavenging enzyme catalase protects neurons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc682a31a79fa107e6b62d019b6eb5f8
https://doi.org/10.1046/j.1471-4159.1996.67041595.x
https://doi.org/10.1046/j.1471-4159.1996.67041595.x
Autor:
Melvyn Baez, Lisa M. Churgay, Mcclure Don B, Leonard N. Boggs, Patrick C. May, Kimberly S. Fuson, Gerald W. Becker
Publikováno v:
Journal of Neurochemistry. 67:1324-1327
Clusterin is a secreted glycoprotein that is markedly induced in many disease states and after tissue injury. In the CNS, clusterin expression is elevated in neuropathological conditions such as Alzheimer's disease (AD), where it is found associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5ef7a8a615cef73e0e78fb78525847
https://doi.org/10.1046/j.1471-4159.1996.67031324.x
https://doi.org/10.1046/j.1471-4159.1996.67031324.x
Publikováno v:
Brain Research. 830:88-93
Basic fibroblast growth factor (bFGF) has been reported to have neuroprotective properties following excitotoxic, metabolic, and oxidative insults. We report here that another FGF family member, FGF-8 is able to protect rat hippocampal cultures from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd341de72a34c5bb56c308f2de49b168
https://doi.org/10.1016/s0006-8993(99)01390-6
https://doi.org/10.1016/s0006-8993(99)01390-6
Autor:
E. Barry Smalstig, Kimberly S. Fuson, Patrick C. May, James A. Clemens, Diane T. Stephenson, Jill Ann Panetta
Publikováno v:
Molecular Brain Research. 42:145-148
Sulfated glycoprotein-2 (SGP-2) is a secreted glycoprotein that along with GFAP has emerged as a prominent molecular marker of neurodegeneration. In the present study, we have evaluated further the relationship between SGP-2, GFAP and neurodegenerati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b51baa43b54a07734cb6cdb3cc37961
https://doi.org/10.1016/s0169-328x(96)00155-6
https://doi.org/10.1016/s0169-328x(96)00155-6
Publikováno v:
Neuroscience Letters. 262:219-221
Glutamate excitotoxicity has been implicated in a variety of acute and chronic neurodegenerative diseases but early phase clinical trials with competitive antagonists at both N -methyl- d -aspartate (NMDA)-receptors and α -amino-3-hydroxy-5-methyl-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78ae8af5f99779458552c90938a152b
https://doi.org/10.1016/s0304-3940(99)00084-1
https://doi.org/10.1016/s0304-3940(99)00084-1
Publikováno v:
Journal of neurochemistry. 61(6)
Amylin, a 37-amino-acid amyloidogenic peptide, bears biophysical similarities to the amyloid-beta peptide (A beta) deposited in Alzheimer's disease. Using embryonic rat hippocampal cultures we tested whether amylin induces neurotoxicity similar to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c937c0b6e6073af10f980f00a7e37965
https://pubmed.ncbi.nlm.nih.gov/8245987
https://pubmed.ncbi.nlm.nih.gov/8245987
Autor:
Paula M. Robison, James A. Clemens, Barry Smalstig, Kimberly S. Fuson, Diane T. Stephenson, Patrick C. May
Publikováno v:
Brain research. Molecular brain research. 15(1-2)
Sulfated glycoprotein-2 (SGP-2) is emerging as a prominent marker of neurodegeneration in mammalian brain. Regulation of brain SGP-2 was studied in adult male Wistar rats subjected to 30 min of forebrain ischemia by four vessel occlusion. By 3 days a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f672cc312dadbd42c294ded019e38518
https://pubmed.ncbi.nlm.nih.gov/1279348
https://pubmed.ncbi.nlm.nih.gov/1279348