Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kimberly R. Gaston"'
Autor:
Amol Karwa, Bethel Asmelash, Kimberly R. Gaston, Carolyn J. Sympson, John N. Freskos, Bich Vu, Tim A. Marzan, Tasha M. Schoenstein, Thomas Rogers, Maureen A. Nickols
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5566-5570
We describe the synthesis, MMP-2 and 9 potency, and in vitro evaluation of a series of α-sulfone hydroxmate MMP inhibitors conjugated to a series of dyes with different absorption/emission lamina maxima's that can be used to visualize tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b998d181d5181c6b9271d7d8ff37ed
https://doi.org/10.1016/j.bmcl.2013.08.050
https://doi.org/10.1016/j.bmcl.2013.08.050
Autor:
Richard B. Dorshow, Bethel Asmelash, William L. Neumann, Jeng-Jong Shieh, Kimberly R. Gaston, John N. Freskos, Richard M. Fitch, Amruta R. Poreddy, Raghavan Rajagopalan, Karen P. Galen
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:2490-2497
Novel pyrazine carboxamides bearing hydrophilic poly(ethylene glycol) (PEG) moieties were designed, synthesized, and evaluated for use as fluorescent glomerular filtration rate (GFR) tracer agents. Among these, compounds 4d and 5c that contain about
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e837a5676a2e95ab4e99b82cc80665
https://doi.org/10.1016/j.bmc.2012.03.015
https://doi.org/10.1016/j.bmc.2012.03.015
Autor:
Kimberly R. Gaston, Amruta R. Poreddy, Jeng-Jong Shieh, William L. Neumann, Richard M. Fitch, Bethel Asmelash, Karen P. Galen, Raghavan Rajagopalan, Richard B. Dorshow, John N. Freskos
Publikováno v:
Journal of Medicinal Chemistry. 54:5048-5058
Various hydrophilic pyrazine-bis(carboxamides) derived from 3,5-diamino-pyrazine-2,5-dicarboxylic acid bearing neutral and anionic groups were prepared and evaluated for use as fluorescent glomerular filtration rate (GFR) tracer agents. Among these,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04410b5155137c0cceaf4e9dd4eabefe
https://doi.org/10.1021/jm200257k
https://doi.org/10.1021/jm200257k
Autor:
Xuerong Gao, Chariklia Sotiriou-Leventis, Kimberly R. Gaston, Nicholas Leventis, Eric W. Bohannan, Christopher D. Doss
Publikováno v:
Journal of Sol-Gel Science and Technology. 23:235-245
This study shows that conventional photolithography can be applied for patterning native or organic dye-doped silica films (∼0.5 μm thick) obtained via a base-catalyzed sol-gel process. Photoresist was spin-coated onto high optical quality xerogel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7800ea76c73125383ec044fb63f81c73
https://doi.org/10.1023/a:1013974915198
https://doi.org/10.1023/a:1013974915198
Autor:
Travis J. Overschmidt, Kimberly R. Gaston, Eric W. Bohannan, Xuerong Gao, Lia Sotiriou-Leventis, Abdel-Monem M. Rawashdeh, Nicholas Leventis, Ian A. Elder
Publikováno v:
The Journal of Physical Chemistry B. 105:3663-3674
In anhydrous CH3CN, 4-benzoyl-N-methylpyridinium cations undergo two reversible, well-separated (ΔE1/2 ∼ 0.6 V) one-electron reductions in analogy to quinones and viologens. If the solvent contains weak protic acids, such as water or alcohols, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::027cac8e058eaa1535e088fe004ada50
https://doi.org/10.1021/jp0107199
https://doi.org/10.1021/jp0107199
Autor:
Gaofei He, Karl Aston, Cynthia M. Dupureur, Kevin J. Koeller, Kimberly R. Gaston, James K. Bashkin
Publikováno v:
Analytical biochemistry. 423(1)
Polyamides (PA) are distamycin-type ligands of DNA that bind the minor groove and are capable of sequence selective recognition. This capability provides a viable route to their development as therapeutics. Presented here is a simple and convenient f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4ff2d1f6179414181a4263ec419e7c
https://pubmed.ncbi.nlm.nih.gov/22342620
https://pubmed.ncbi.nlm.nih.gov/22342620
Autor:
J. Micah Wilcox, Bethel Asmelash, Rana Kumar, Richard M. Fitch, Karen P. Galen, Jeng-Jong Shieh, Jolette K. Wojdyla, Amruta R. Poreddy, James G. Kostelc, John N. Freskos, Raghavan Rajagopalan, William L. Neumann, Richard B. Dorshow, Tim A. Marzan, Kimberly R. Gaston, Martin P. Debreczeny, Tasha M. Schoenstein
Publikováno v:
SPIE Proceedings.
Accurate measurement of glomerular filtration rate (GFR) at the bedside is highly desirable in order to assess renal function in real-time, which is currently an unmet clinical need. In our pursuit to develop exogenous fluorescent tracers as GFR mark
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87fd694bf617e568f8adb4b6c01dd8f9
https://doi.org/10.1117/12.874917
https://doi.org/10.1117/12.874917
Autor:
Jeng J. Shieh, Karen P. Galen, William L. Neumann, Richard M. Fitch, Jolette K. Wojdyla, Bethel Asmelash, Amruta R. Poreddy, Raghavan Rajagopalan, Kevin D. Belfield, John N. Freskos, Hyo Yang Ahn, James G. Kostelc, James M. Wilcox, Richard B. Dorshow, Tasha M. Schoenstein, Kimberly R. Gaston, Martin P. Debreczeny
Publikováno v:
SPIE Proceedings.
Rapid assessment of glomerular filtration rate (GFR), which measures the amount of plasma filtered through the kidney within a given time, would greatly facilitate monitoring of renal function for patients at the bedside in the clinic. In our pursuit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4822d4ecfe1165750894456ce695b4f3
https://doi.org/10.1117/12.809287
https://doi.org/10.1117/12.809287
Autor:
Karen P. Galen, William L. Neumann, Timothy A. Marzan, Jeng-Jong Shieh, Bethel Asmelash, Kimberly R. Gaston, Martin P. Debreczeny, Lori K. Chinen, Raghavan Rajagopalan, Richard M. Fitch, Richard B. Dorshow, John N. Freskos, Amruta R. Poreddy
Publikováno v:
SPIE Proceedings.
The ability to continuously monitor renal function via the glomerular filtration rate (GFR) in the clinic is currently an unmet medical need. To address this need we have developed a new series of hydrophilic fluorescent probes designed to clear via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df9f93e22e6244fcdb7bc6572422cb77
https://doi.org/10.1117/12.763697
https://doi.org/10.1117/12.763697
Autor:
James K. Bashkin, Kevin J. Koeller, Cynthia M. Dupureur, Gaofei He, Karl Aston, Kimberly R. Gaston
Publikováno v:
Analytical Biochemistry. 425:113
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04cf7c5de5067134ffe7276b03999a85
https://doi.org/10.1016/j.ab.2012.03.025
https://doi.org/10.1016/j.ab.2012.03.025