Modified in vivo comet assay detects the genotoxic potential of 14-hydroxycodeinone, an α,β-unsaturated ketone in oxycodone

Autor: Kamala, Pant, Nicholas, Roden, Charles, Zhang, Shannon, Bruce, Craig, Wood, Kimberly, Pendino

Publikováno v: Environmental and molecular mutagenesis. 56(9)

14-Hydroxycodeinone (14-HC) is an α,β-unsaturated ketone impurity found in oxycodone drug substance and has a structural alert for genotoxicity. 14-HC was tested in a combined Modified and Standard Comet Assay to determine if the slight decrease in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d42f76528b8bb2458a56d0621476c1b
https://pubmed.ncbi.nlm.nih.gov/25913631

Contributors

Autor: Husein Ajwa, Iris S. Ale, Sandra L. Allen, Judith Alsop, Gail Arce, D.J. Ashworth, Sharada Balakrishnan, John B. Barnett, Dana B. Barr, Terrell Barry, Ronald E. Baynes, Sheryl Beauvais, Karin S. Bentley, Craig E. Bernard, Nida Besbelli, Richard Billington, Ann M. Blacker, Jerry N. Blancazo, Charles B. Breckenridge, Gerald T. Brooks, James Bruckner, Kathleen M. Brundage, Quang Bui, Franca M. Buratti, James S. Bus, Geoffrey M. Calvert, Linda L. Carlock, John E. Casida, Howard W. Chambers, Janice E. Chambers, Heidi P. Chan, Graham Chester, J. Marshall Clark, Thomas Class, M. Scott Clifton, Roger Cochran, Emma Di Consiglio, Curtis C. Dary, Franck E. Dayan, Allison L. De Vries, Kelly J. Dix, Michael H. Dong, Timothy A. Dotson, John Doull, Jeffrey H. Driver, Stephen O. Duke, M. Bigelow Dyk, David A. Eastmond, David L. Eaton, Marion Ehrich, David L. Eisenbrandt, J. Charles Eldridge, Jeffrey B. Evans, Donna Farmer, Allan S. Felsot, Penelope A. Fenner-Crisp, Joan L. Fletcher, Sara Flores, Roy Fortmann, Toshio Fujita, Derek W. Gammon, Suduan Gao, V.F. Garry, Sean C. Gehen, Panos Georgopoulos, B.B. Gollapudi, Elliot B. Gordon, F. Guerino, Thomas R. Hanley, Lindsay Hanson, Paul R. Harp, Michael C. Harrass, Jane E. Harris, Wayland J. Hayes, Thomas Hertner, Frederick G. Hess, William F. Heydens, Ernest Hodgson, L. Holden, Jon A. Hotchkiss, Susan Hurt, Sastry Isukapalli, Seshadri Iyengar, Poorni Iyer, Inge M. Jensen, Russell L. Jones, Bernard S. Jortner, Hideo Kaneko, Robert J. Kavlock, Iain D. Kelly, Michael P. Kenna, Elke Kennepohl, Young Soo Keum, Jeong-Han Kim, Loreen Kleinschmidt, Dennis R. Klonne, James B. Knaak, Mike E. Krolski, Ian C. Lamb, Richard L. Lampman, Mikael Langner, Jennifer L. Lantz, Dominique Lasserre-Bigot, Edward D. Levin, Qing X. Li, Jing Liu, Edward A Lock, Marcello Lotti, Curt Lunchick, A.V. Lyubimov, Howard Maibach, Lisa E. Maier, Susan Makris, Mark J. Manning, Rex E. Marsh, Melanie Marty, Ursula May-Hertl, Thomas McCurdy, Tom McKone, Edward C. Meek, Louise N. Mehler, Gary J. Mihlan, Thomas B. Moore, Marsha K. Morgan, Ian C. Munro, Toshio Narahashi, Keiichiro Nishimura, Robert J. Novak, William J. Ntow, Michael A. O’Malley, Frederick W. Oehme, Janet Ollinger, Thomas G. Osimitz, Muhilan D. Pandian, P.P. Parsons, Merle G. Paule, Virginie Payraudeau, Erin C. Peck, Alain F. Pelfrène, Kimberly Pendino, Barbara J. Petersen, Amanda L. Piccirillo, Vincent J. Piccirillo, Joachim D. Pleil, Kathryn Ponnock, Carey Pope, Robert H. Poppenga, Su-wei Qi, Ruijun Qin, Deborah Ramsingh, Lawrence W. Reiter, Rudy J. Richardson, Leonard Ritter, Jim E. Riviere, John H. Ross, Karl K. Rozman, Andrew L. Rubin, Michael K. Rust, Luis O. Ruzo, Terrell P. Salmon, G.K. (Ghona) Sangha, James N. Seiber, Frank Selman, Larry P. Sheets, Linda S. Sheldon, Marilyn Silva, James W. Simpkins, William Slikker, Paul Slovic, Andrew G. Smith, Wayne R. Snodgrass, Jon R. Sobus, David M. Soderlund, Keith R. Solomon, Frank Spurlock, James T. Stevens, Tammy E. Stoker, W.T. Stott, Daniel L. Sudakin, Chiyozo Takayama, Emanuela Testai, Thomas Thongsinthusak, Charles Timchalk, Olga A. Timofeeva, Abraham J. Tobia, Rogelio Tornero-Velez, Nicolle S. Tulve, Matazaemon Uchida, István Ujváry, Daniel Vallero, Bennard van Ravenswaay, Felix Waechter, Edgar Weber, Ronald C. Wester, Paul Whatling, Gary K. Whitmyre, Heinrich Wicke, Sanjeeva J. Wijeyesakere, Martin F. Wilks, Alan G.E. Wilson, Barry W. Wilson, Michael D. Woodward, Jayne Wright, S.R. Yates, Masanori Yoshida, Bruce M. Young, Frank G. Zalom, Valerie Zartarian, Hongbo Zhai, Xiaofei Zhang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a870b5ec229c808850c63447b71171b2
https://doi.org/10.1016/b978-0-12-374367-1.00124-5

Expression of prostaglandin GH synthase (cyclooxygenase) during murine fetal thymic development

Autor: Richard R. Schmidt, Kenneth P. Chepenik, Dan Goldowitz, Michael B. Prystowsky, Pierette M. Appasamy, Kimberly Pendino

Publikováno v: Cellular Immunology. 137:341-357

Fetal thymic lobes in organ culture have been shown to have the capacity to metabolize [14C]arachidonic acid (AA) to prostaglandins (PGs), including 6-ketoPGF1α, PGF2α, PGE2, and PGA2. Inhibition of AA metabolism results in inhibition of growth and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0ea319eedad3543f99c1554a560a74
https://doi.org/10.1016/0008-8749(91)90084-o

Validation of echocardiography assessment of cardiac function in conscious beagle dogs with propranolol

Autor: Kimberly Pendino, Jonathan Marotti, Horst Staudner, Theresa Bartko, Cheryl Heidelberger, Xing Cheng, Gerard Hirkaler

Publikováno v: Journal of Pharmacological and Toxicological Methods. 62:e9-e10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40fa5a4a96f2ca1b52d9f7f3eb7bd982
https://doi.org/10.1016/j.vascn.2010.11.031