Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Kimberly N. Smitheman"'
Autor:
Kimberly N. Smitheman, Tesa M. Severson, Satyajit R. Rajapurkar, Michael T. McCabe, Natalie Karpinich, James Foley, Melissa B. Pappalardi, Ashley Hughes, Wendy Halsey, Elizabeth Thomas, Christopher Traini, Kelly E. Federowicz, Jenny Laraio, Fredrick Mobegi, Geraldine Ferron-Brady, Rabinder K. Prinjha, Christopher L. Carpenter, Ryan G. Kruger, Lodewyk Wessels, Helai P. Mohammad
Publikováno v:
Haematologica, Vol 104, Iss 6 (2019)
Lysine specific demethylase 1 (LSD1) is a histone modifying enzyme that suppresses gene expression through demethylation of lysine 4 on histone H3. The anti-tumor activity of GSK2879552 and GSK-LSD1, potent, selective irreversible inactivators of LSD
Externí odkaz:
https://doaj.org/article/bb08125c1aa14689b48e6b606c7f9587
Autor:
Weiyi Peng, Helai P. Mohammad, Patrick Hwu, Ryan G. Kruger, Olena Barbash, Linghua Wang, Mark T. Bedford, Qin Feng, Guangchun Han, Chunyu Xu, Leila J. Williams, Jenny Laraio, Satyajit Rajapurkar, Christian Sherk, Jiakai Hou, Yunfei Wang, Kimberly N. Smitheman, Shane O'Brien, Leilei Shi, Andrew Fedoriw
Supplementary Figure from Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell–Mediated Antitumor Immune Responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6dfa5fcb5450c54402a7d5bd6933d1
https://doi.org/10.1158/2326-6066.22544108
https://doi.org/10.1158/2326-6066.22544108
Autor:
Weiyi Peng, Helai P. Mohammad, Patrick Hwu, Ryan G. Kruger, Olena Barbash, Linghua Wang, Mark T. Bedford, Qin Feng, Guangchun Han, Chunyu Xu, Leila J. Williams, Jenny Laraio, Satyajit Rajapurkar, Christian Sherk, Jiakai Hou, Yunfei Wang, Kimberly N. Smitheman, Shane O'Brien, Leilei Shi, Andrew Fedoriw
Supplementary Table from Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell–Mediated Antitumor Immune Responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23581ebfc323465362b79ff448ebda54
https://doi.org/10.1158/2326-6066.22544105
https://doi.org/10.1158/2326-6066.22544105
Autor:
Weiyi Peng, Helai P. Mohammad, Patrick Hwu, Ryan G. Kruger, Olena Barbash, Linghua Wang, Mark T. Bedford, Qin Feng, Guangchun Han, Chunyu Xu, Leila J. Williams, Jenny Laraio, Satyajit Rajapurkar, Christian Sherk, Jiakai Hou, Yunfei Wang, Kimberly N. Smitheman, Shane O'Brien, Leilei Shi, Andrew Fedoriw
Protein arginine methyltransferases (PRMT) are a widely expressed class of enzymes responsible for catalyzing arginine methylation on numerous protein substrates. Among them, type I PRMTs are responsible for generating asymmetric dimethylarginine. By
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6012567a496d1caf29d286b0c6d25ca5
https://doi.org/10.1158/2326-6066.c.6550529.v1
https://doi.org/10.1158/2326-6066.c.6550529.v1
Autor:
Ari M. Melnick, Martin Carroll, Ross L. Levine, Elisabeth M. Paietta, Caretha L. Creasy, Ryan G. Kruger, Gail J. Roboz, H. Leighton Grimes, David Muench, Monica L. Guzman, Martin S. Tallman, Omar Abdel-Wahab, Alan H. Shih, Kimberly N. Smitheman, Helai P. Mohammad, Johannes C. Hellmuth, Meng Li, Jacob L. Glass, Cem Meydan, Tak C. Lee, Francine E. Garrett-Bakelman, Matt Teater, Cihangir Duy
Supplementary Figures S1-S6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03aea8478ab5c1365cf9f64a733af523
https://doi.org/10.1158/2159-8290.22536274.v1
https://doi.org/10.1158/2159-8290.22536274.v1
Autor:
Tona M. Gilmer, Li Liu, Sylvie G. Laquerre, Scott H. Dickerson, Kimberly N. Smitheman, Ashley M. Hughes, Maureen R. Bleam, Vivian Zhang, Stephen D. Eastman, James G. Greger
PDF file - 276K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612cd6282bf70c0b319d1c53a2e6856c
https://doi.org/10.1158/1535-7163.22499103.v1
https://doi.org/10.1158/1535-7163.22499103.v1
Autor:
Ari M. Melnick, Martin Carroll, Ross L. Levine, Elisabeth M. Paietta, Caretha L. Creasy, Ryan G. Kruger, Gail J. Roboz, H. Leighton Grimes, David Muench, Monica L. Guzman, Martin S. Tallman, Omar Abdel-Wahab, Alan H. Shih, Kimberly N. Smitheman, Helai P. Mohammad, Johannes C. Hellmuth, Meng Li, Jacob L. Glass, Cem Meydan, Tak C. Lee, Francine E. Garrett-Bakelman, Matt Teater, Cihangir Duy
Frequency of recurrent mutations in the AML cohort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859becb8853e4d22156e17e8ab94b622
https://doi.org/10.1158/2159-8290.22536268.v1
https://doi.org/10.1158/2159-8290.22536268.v1
Autor:
Tona M. Gilmer, Li Liu, Sylvie G. Laquerre, Scott H. Dickerson, Kimberly N. Smitheman, Ashley M. Hughes, Maureen R. Bleam, Vivian Zhang, Stephen D. Eastman, James G. Greger
Recent results from clinical trials with the BRAF inhibitors GSK2118436 (dabrafenib) and PLX4032 (vemurafenib) have shown encouraging response rates; however, the duration of response has been limited. To identify determinants of acquired resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::342d7af81845cc3449fb50863d2f5fa4
https://doi.org/10.1158/1535-7163.c.6536067
https://doi.org/10.1158/1535-7163.c.6536067
Autor:
Ari M. Melnick, Martin Carroll, Ross L. Levine, Elisabeth M. Paietta, Caretha L. Creasy, Ryan G. Kruger, Gail J. Roboz, H. Leighton Grimes, David Muench, Monica L. Guzman, Martin S. Tallman, Omar Abdel-Wahab, Alan H. Shih, Kimberly N. Smitheman, Helai P. Mohammad, Johannes C. Hellmuth, Meng Li, Jacob L. Glass, Cem Meydan, Tak C. Lee, Francine E. Garrett-Bakelman, Matt Teater, Cihangir Duy
Disruption of epigenetic regulation is a hallmark of acute myeloid leukemia (AML), but epigenetic therapy is complicated by the complexity of the epigenome. Herein, we developed a long-term primary AML ex vivo platform to determine whether targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9f317234170b06b2897802a4a7c03d
https://doi.org/10.1158/2159-8290.c.6548089.v1
https://doi.org/10.1158/2159-8290.c.6548089.v1
Autor:
Andrew Fedoriw, Leilei Shi, Shane O'Brien, Kimberly N. Smitheman, Yunfei Wang, Jiakai Hou, Christian Sherk, Satyajit Rajapurkar, Jenny Laraio, Leila J. Williams, Chunyu Xu, Guangchun Han, Qin Feng, Mark T. Bedford, Linghua Wang, Olena Barbash, Ryan G. Kruger, Patrick Hwu, Helai P. Mohammad, Weiyi Peng
Publikováno v:
Cancer Immunol Res
Protein arginine methyltransferases (PRMT) are a widely expressed class of enzymes responsible for catalyzing arginine methylation on numerous protein substrates. Among them, type I PRMTs are responsible for generating asymmetric dimethylarginine. By