Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Kimberly Marlen"'
Persistent repression of tau in the brain using engineered zinc finger protein transcription factors
Autor:
Susanne Wegmann, Bradley T. Hyman, Annemarie Ledeboer, Jeffrey C. Miller, Marta Perez-Rando, Kimberly Marlen, Richard T. Surosky, Bryan Zeitler, Caitlin Commins, Alison Chase, Michael C. Holmes, Sarah J. Hinkley, Alicia Goodwin, Riley N. Bannon, Lei Zhang, Brigit E. Riley, Hoang-Oanh B. Nguyen, Sarah L. DeVos, Edward J. Rebar, Ashley B. Robbins, Stephen Lam, Rainier Amora, Irina Ankoudinova, Qi Yu, Amy M. Pooler, Hung Tran, Nicholas A. Scarlott, Bianca T. Corjuc, Danny MacKenzie, Fyodor D. Urnov, H. Steve Zhang, Lisa Diez, Rachel E. Bennett
Publikováno v:
Science advances 7(12), eabe1611-(2021). doi:10.1126/sciadv.abe1611
Science Advances
Science Advances
Zinc finger proteins targeted to MAPT safely repress tau mRNA in the adult mouse brain and protect against Aβ toxicity.
Neuronal tau reduction confers resilience against β-amyloid and tau-related neurotoxicity in vitro and in vivo. Here, we in
Neuronal tau reduction confers resilience against β-amyloid and tau-related neurotoxicity in vitro and in vivo. Here, we in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1e249560ae8a0539e415f467dba78e
Autor:
Kimberly Marlen, John F. Palma, Francine M. Gregoire, Jeffrey D. Johnson, Gann G. Xu, Linda Reilly, Anthony C. Schweitzer, Yun-Ping Zhou, John E. Blume
Publikováno v:
Journal of Biological Chemistry. 278:51316-51323
The hyperlipidemia and hyperglycemia of the diabetic state accelerate beta-cell dysfunction, yet the mechanisms are not fully defined. We used rat islet-specific oligonucleotide arrays (Metabolex Rat Islet Genechips) to identify genes that are coordi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58c47ad22522367f80d15cb02d294ad3
https://doi.org/10.1074/jbc.m307972200
https://doi.org/10.1074/jbc.m307972200
Autor:
Bryan Zeitler, Omar L. Francone, David Thomson, Kimberly Marlen, Chiocco Matthew, David Paschon, H. Steve Zhang, Steven Froelich, Qi Yu, Jeffrey C. Miller, Debra Klatte, Vivian Choi, Anne-Renee Graham, Fyodor D. Urnov, Philip D. Gregory, Edward J. Rebar
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 87:A2.4-A3
There are approximately 7000 known rare and orphan diseases, over a third of which affect the central nervous system, virtually all do not have adequate treatment options. Shire is committed to developing innovative medicines to treat the fundamental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e04b2cc9d748316148d928bf6df863f1
https://doi.org/10.1136/jnnp-2016-314597.7
https://doi.org/10.1136/jnnp-2016-314597.7