Výsledky vyhledávání - "Kimberly MacGorman"

Single‐Dose Pharmacokinetics, Safety, and Tolerability of Avadomide (CC‐122) in Subjects With Mild, Moderate, or Severe Renal Impairment

Autor: Jian Chen, Maria Palmisano, Yan Li, Liangang Liu, Kimberly MacGorman, Matthew Hoffmann, Simon Zhou

Publikováno v: Clinical Pharmacology in Drug Development. 9:785-796

CC-122 (Avadomide) is a nonphthalimide analogue of thalidomide that has multiple pharmacological activities including immune modulation of several immune cell subsets, antigrowth activity, antiproliferative activity, and antiangiogenic activity. CC-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42292c74cd5473687bbc2095906d3507
https://doi.org/10.1002/cpdd.760

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Evaluation of iberdomide and cytochrome p450 drug-drug interaction potential in vitro and in a phase 1 study in healthy subjects

Autor: Sekhar Surapaneni, Maria Palmisano, Christian Atsriku, Liangang Liu, Ying Ye, Kimberly MacGorman, Allison Gaudy, Yongjun Xue

Publikováno v: European journal of clinical pharmacology. 77(2)

Iberdomide is a cereblon E3 ligase modulator capable of redirecting the protein degradation machinery of the cell towards the elimination of target proteins potentially driving therapeutic effects. In vitro studies demonstrated that iberdomide predom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746f218641d1e010b46fb0925f41f3f2
https://pubmed.ncbi.nlm.nih.gov/32965548

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