Výsledky vyhledávání - "Kimberly M. Lee"

Radiation-induced loss of cell surface CD47 enhances immune-mediated clearance of human papillomavirus-positive cancer

Autor: Daniel W. Vermeer, John H. Lee, Annie M. Bruns, Paola D. Vermeer, William C. Spanos, Kimberly M. Lee

Publikováno v: International Journal of Cancer. 133:120-129

The increasing incidence of human papillomavirus (HPV) related oropharyngeal squamous cell carcinoma (OSSC) demands development of novel therapies. Despite presenting at a more advanced stage, HPV(+) oropharyngeal squamous cell carcinoma (OSCC) have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f698df873693d581fff69d0c76efc52f
https://doi.org/10.1002/ijc.28015

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A non-oncogenic HPV 16 E6/E7 vaccine enhances treatment of HPV expressing tumors

Autor: John H. Lee, Frank R. Jones, Paola D. Vermeer, Stephanie Balcaitis, Bryant G. Wieking, Daniel W. Vermeer, William C. Spanos, Elizabeth Gabitzsch, Younong Xu, Walter T. Lee, Joseph P. Balint, Kimberly M. Lee

Publikováno v: Cancer gene therapy

Human papillomaviruses (HPVs) are the causative factor for greater than 90% of cervical cancers and 25% of head and neck cancers. The incidence of HPV positive (+) head and neck squamous cell carcinomas (HNSCCs) has greatly increased in the last 30 y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b069ba6cac69d98c99218d1ed75f6ca6
https://doi.org/10.1038/cgt.2012.55

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Telomere restoration and extension of proliferative lifespan in dyskeratosis congenita fibroblasts

Autor: Kimberly M. Lee, Aloysius J. Klingelhutz, Soraya Riley, Elizabeth A. Chavez, Erik Westin, Frederick D. Goldman, Francoise A. Gourronc, Peter M. Lansdorp

Publikováno v: Aging Cell. 6:383-394

Dyskeratosis congenita (DC), an inherited bone marrow failure syndrome, is caused by defects in telomerase. Somatic cells from DC patients have shortened telomeres and clinical symptoms are most pronounced in organs with a high cell turnover, includi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91ed6f65fae720724b1369210df3638
https://doi.org/10.1111/j.1474-9726.2007.00288.x

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QscR, a modulator of quorum-sensing signal synthesis and virulence in Pseudomonas aeruginosa

Autor: Sudha Chugani, Colin Manoil, E. P. Greenberg, David A. D'Argenio, Marvin Whiteley, Kimberly M. Lee

Publikováno v: Proceedings of the National Academy of Sciences. 98:2752-2757

The opportunistic pathogenic bacterium Pseudomonas aeruginosa uses quorum-sensing signaling systems as global regulators of virulence genes. There are two quorum-sensing signal receptor and signal generator pairs, LasR–LasI and RhlR–RhlI. The rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1cd647f0ea9c87d33cd39dafa7dc8c
https://doi.org/10.1073/pnas.051624298

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Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa

Autor: Kimberly M. Lee, E. P. Greenberg, Marvin Whiteley

Publikováno v: Proceedings of the National Academy of Sciences. 96:13904-13909

Bacteria communicate with each other to coordinate expression of specific genes in a cell density-dependent fashion, a phenomenon called quorum sensing and response. Although we know that quorum sensing via acyl-homoserine lactone (HSL) signals contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c1ffa5134da17ff8525f5c2fa176cc5
https://doi.org/10.1073/pnas.96.24.13904

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ErbB2, EphrinB1, Src kinase and PTPN13 signaling complex regulates MAP kinase signaling in human cancers

Autor: Shridar Ganesan, Wiljan Hendriks, Aloysius J. Klingelhutz, Daniel W. Vermeer, Ronny Drapkin, Megan Bell, Kimberly M. Lee, Erhan Bilal, Paola D. Vermeer, John H. Lee, Gyan Bhanot, Byrant G. Wieking

Publikováno v: PLoS One, 7, 1
PLoS ONE, Vol 7, Iss 1, p e30447 (2012)
PLoS One, 7
PLoS ONE

Contains fulltext : 107772.pdf (Publisher’s version ) (Open Access) In non-cancerous cells, phosphorylated proteins exist transiently, becoming de-phosphorylated by specific phosphatases that terminate propagation of signaling pathways. In cancers,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3274b85f14b55a0e328f14a4c43e505f
https://hdl.handle.net/2066/107772

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Abstract LB-143: ErbB2, EphrinB1, Src kinase and PTPN13 signaling complex regulates MAP kinase signaling in human cancers

Autor: Kimberly M. Lee, Ronny I. Drapkin, Bryant G. Wieking, Daniel W. Vermeer, John H. Lee, Megan Bell, Paola D. Vermeer, Shridar Ganesan

Publikováno v: Cancer Research. 72:LB-143

Tyrosine kinases, like the ErbB and Src families, can mediate potent oncogenic growth and are successful therapeutic targets of human cancers. However, many cancer cells overcome or successfully modulate these downstream signaling cascades in the abs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbf32a1867275da3569e1c99ccac06e9
https://doi.org/10.1158/1538-7445.am2012-lb-143

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Abstract 2114: PTPN13 regulates ephrinB1 reverse signaling, MAP kinase signaling and tumor growth

Autor: Bryant G. Wieking, Kimberly M. Lee, Daniel W. Vermeer, John H. Lee, Nichole Haag, Paola D. Vermeer

Publikováno v: Cancer Research. 71:2114-2114

Human papillomaviruses (HPV's) are a causative factor in over 90% of cervical and 25% of head and neck squamous cell carcinomas. The C-terminus of high risk HPV 16 E6 associates and degrades PTPN13, a non-receptor protein tyrosine phosphatase. PTPN13

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90a03130fed2183766ee8603ee319b28
https://doi.org/10.1158/1538-7445.am2011-2114

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