Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Kimberly M. Lamb"'
Autor:
Amel Dudakovic, Andrew J. Wiemer, Sara E. Dietz, Kimberly M. Lamb, Laura A. Vonnahme, Raymond J. Hohl
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 324:1028-1036
Inhibitors of isoprenoid synthesis are widely used for treatment of human diseases, including hypercholesterolemia and osteoporosis, and they have the potential to be useful for treatment of cancer. Statin drugs inhibit the enzyme HMG-CoA reductase,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e727d62f6e225574c5457f76ffa7bec0
https://doi.org/10.1124/jpet.107.132217
https://doi.org/10.1124/jpet.107.132217
Autor:
Larry W. Shull, David F. Wiemer, Rocky J. Barney, Andrew J. Wiemer, Raymond J. Hohl, Kimberly M. Lamb, Brian M. Wasko, Jose S. Yu
Publikováno v:
Bioorganicmedicinal chemistry. 16(7)
Nitrogenous bisphosphonate inhibitors of farnesyl disphosphate synthase have been used clinically for treatment of bone disease. Because many of their effects may be mediated by depletion of geranylgeranyl diphosphate, our group has sought compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217bb4c0a9010dfb4f76fd38f0977dbb
https://pubmed.ncbi.nlm.nih.gov/18308574
https://pubmed.ncbi.nlm.nih.gov/18308574
Publikováno v:
Bioorganicmedicinal chemistry. 16(1)
Nitrogenous bisphosphonates are used clinically to reduce bone resorption associated with osteoporosis or metastatic bone disease, and are recognized as inhibitors of farnesyl diphosphate synthase. Inhibition of this enzyme decreases cellular levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae6b2ad104ffbcb2a6ccc0067bd4cca
https://pubmed.ncbi.nlm.nih.gov/17905588
https://pubmed.ncbi.nlm.nih.gov/17905588