Telomere-to-telomere assemblies of cattle and sheep Y-chromosomes uncover divergent structure and gene content

Autor: Temitayo A. Olagunju, Benjamin D. Rosen, Holly L. Neibergs, Gabrielle M. Becker, Kimberly M. Davenport, Christine G. Elsik, Tracy S. Hadfield, Sergey Koren, Kristen L. Kuhn, Arang Rhie, Katie A. Shira, Amy L. Skibiel, Morgan R. Stegemiller, Jacob W. Thorne, Patricia Villamediana, Noelle E. Cockett, Brenda M. Murdoch, Timothy P. L. Smith

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract Reference genomes of cattle and sheep have lacked contiguous assemblies of the sex-determining Y chromosome. Here, we assemble complete and gapless telomere to telomere (T2T) Y chromosomes for these species. We find that the pseudo-autosomal

Externí odkaz: https://doaj.org/article/45bdcbd5b5484c859b4fa84a96daccf4

Single-Cell Sequencing Technology in Ruminant Livestock: Challenges and Opportunities

Autor: Avery Lyons, Jocelynn Brown, Kimberly M. Davenport

Publikováno v: Current Issues in Molecular Biology, Vol 46, Iss 6, Pp 5291-5306 (2024)

Advancements in single-cell sequencing have transformed the genomics field by allowing researchers to delve into the intricate cellular heterogeneity within tissues at greater resolution. While single-cell omics are more widely applied in model organ

Externí odkaz: https://doaj.org/article/b19ad2b80f8343f68fb08815f029f1fc

Characterizing Genetic Regulatory Elements in Ovine Tissues

Autor: Kimberly M. Davenport, Alisha T. Massa, Suraj Bhattarai, Stephanie D. McKay, Michelle R. Mousel, Maria K. Herndon, Stephen N. White, Noelle E. Cockett, Timothy P. L. Smith, Brenda M. Murdoch, on behalf of The Ovine FAANG Project Consortium

Publikováno v: Frontiers in Genetics, Vol 12 (2021)

The Ovine Functional Annotation of Animal Genomes (FAANG) project, part of the broader livestock species FAANG initiative, aims to identify and characterize gene regulatory elements in domestic sheep. Regulatory element annotation is essential for id

Externí odkaz: https://doaj.org/article/732f420d79c84278a7af1a1086d56711

Disruption of CSF2RA in the bovine preimplantation embryo reduces development and affects embryonic gene expression in utero

Autor: Froylan Sosa, Kyungjun Uh, Jéssica N Drum, Katy S Stoecklein, Kimberly M Davenport, M Sofia Ortega, Kiho Lee, Peter J Hansen

Publikováno v: Reproduction and Fertility. 4

The hypothesis that colony-stimulating factor 2 (CSF2) plays a role in the preimplantation development of the bovine embryo was tested by evaluating consequences of inactivation of CSF2RA (the functional receptor in the embryo) for the development of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64e638679a59f262848dc24348dd9a60
https://doi.org/10.1530/raf-23-0001

An improved ovine reference genome assembly to facilitate in-depth functional annotation of the sheep genome

Autor: Kimberly M Davenport, Derek M Bickhart, Kim Worley, Shwetha C Murali, Mazdak Salavati, Emily L Clark, Noelle E Cockett, Michael P Heaton, Timothy P L Smith, Brenda M Murdoch, Benjamin D Rosen

Publikováno v: Davenport, K M, Bickhart, D M, Worley, K C, Murali, S C, Salavati, M, Clark, E, Cockett, N E, Heaton, M P, Smith, T P L, Murdoch, B & Rosen, B D 2022, ' An improved ovine reference genome assembly to facilitate in depth functional annotation of the sheep genome ', GigaScience, vol. 11, giab096 . https://doi.org/10.1093/gigascience/giab096

BackgroundThe domestic sheep (Ovis aries) is an important agricultural species raised for meat, wool, and milk across the world. A high-quality reference genome for this species enhances the ability to discover genetic mechanisms influencing biologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834726c5e7d50dc09fccc068ce6519c0
https://doi.org/10.1093/gigascience/giab096