Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kimberly L. W. Schultz"'
Autor:
Kimberly L. W. Schultz, Victoria K. Baxter, Rebecca Glowinski, Diane E. Griffin, Elizabeth M. Troisi
Publikováno v:
Journal of General Virology
Interferon (IFN) regulatory factors (IRFs) are important determinants of the innate response to infection. We evaluated the role(s) of combined and individual IRF deficiencies in the outcome of infection of C57BL/6 mice with Sindbis virus, an alphavi
Autor:
Emanuel F. Petricoin, Diane E. Griffin, Jane X. Yeh, Valerie S. Calvert, Kimberly L. W. Schultz
Publikováno v:
Proc Natl Acad Sci U S A
Alphaviruses are positive-sense, enveloped RNA viruses that are important causes of viral encephalomyelitis. Sindbis virus (SINV) is the prototype alphavirus and preferentially infects neurons in rodents to induce an encephalomyelitis similar to the
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76412 (2013)
Interferon (IFN)-gamma is an important component of the immune response to viral infections that can have a role both in controlling virus replication and inducing inflammatory damage. To determine the role of IFN-gamma in fatal alphavirus encephalit
Externí odkaz:
https://doaj.org/article/ee12e8712a23497283f3422a0911840d
Publikováno v:
J Virol
Alphaviruses are enveloped, positive-sense RNA viruses that are important causes of viral encephalomyelitis. Sindbis virus (SINV) infects the neurons of rodents and is a model for studying factors that regulate infection of neuronal cells. The outcom
Publikováno v:
Journal of Virology. 87:7816-7827
The innate immune response to viral infection frequently includes induction of type I interferons (IFN), but many viruses have evolved ways to block this response and increase virulence. In vitro studies of IFN production after infection of susceptib
Autor:
Barbara S. Slusher, Diane E. Griffin, Sivabalan Manivannan, Victoria K. Baxter, Kimberly L. W. Schultz
Publikováno v:
Journal of Virology
Inflammation is a necessary part of the response to infection but can also cause neuronal injury in both infectious and autoimmune diseases of the central nervous system (CNS). A neurovirulent strain of Sindbis virus (NSV) causes fatal paralysis in a
For recovery from infection, the immune response in the central nervous system (CNS) must eliminate or control virus replication without destroying nonrenewable, essential cells. Thus, upon intracellular virus detection, the infected cell must initia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::716ac60b5733b9afd6312ef5714c6333
https://doi.org/10.1016/b978-0-12-374279-7.14022-6
https://doi.org/10.1016/b978-0-12-374279-7.14022-6
Publikováno v:
Journal of Virology. 85:8348-8358
Apoptosis is an important antivirus defense by virtue of its impact on virus multiplication and pathogenesis. To define molecular mechanisms by which viruses are detected and the apoptotic response is initiated, we examined the antiviral role of host
Publikováno v:
Journal of Virology. 83:11123-11132
Apoptosis is an important antivirus defense. To define the poorly understood pathways by which invertebrates respond to viruses by inducing apoptosis, we have identified replication events that trigger apoptosis in baculovirus-infected cells. We used
Publikováno v:
Journal of Virology. 83:5640-5647
Each Sindbis virus (SINV) surface glycoprotein has two sites for N-linked glycosylation (E1 positions 139 and 245 [E1-139 and E1-245] and E2 positions 196 and 318 [E2-196 and E2-318]). Studies of SINV strain TE12 mutants with each site eliminated ide