Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kimberly L. Stark"'
Autor:
Robert Brendza, Xiaoying Gao, Kimberly L. Stark, Han Lin, Seung-Hye Lee, Changyun Hu, Hao Cai, Danielle DiCara, Yi-Chun Hsiao, Hai Ngu, Oded Foreman, Miriam Baca, Monika Dohse, Jean-Phillipe Fortin, Racquel Corpuz, Dhaya Seshasayee, Amy Easton, Gai Ayalon, Isidro Hötzel, Ben Chih
Publikováno v:
Neurobiology of Disease, Vol 177, Iss , Pp 105969- (2023)
Parkinson's disease (PD), a neurodegenerative disease affecting dopaminergic (DA) neurons, is characterized by decline of motor function and cognition. Dopaminergic cell loss is associated with accumulation of toxic alpha synuclein aggregates. As DA
Externí odkaz:
https://doaj.org/article/f3994bb352724f55b0845dad814ba7b9
Autor:
Søren Warming, Lorena Riol-Blanco, Shannon D. Shields, Wyne P. Lee, David H. Hackos, Michelle Dourado, Keith R. Anderson, Rebecca M. Reese, Alessia Balestrini, Kimberly L. Stark, Eric Suto
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
The transient receptor potential (TRP) superfamily of ion channels has garnered significant attention by the pharmaceutical industry. In particular, TRP channels showing high levels of expression in sensory neurons such as TRPV1, TRPA1, and TRPM8, ha
Autor:
Agatha J. Kruse, William J. Meilandt, Guita Lalehzadeh, Hai Ngu, Oded Foreman, Martin Weber, Jose Imperio, Tiffany Wu, Morgan Sheng, David V. Hansen, Kimberly L. Stark, Zora Modrusan, Mandy Kwong, Karpagam Srinivasan, Brad A. Friedman, Alvin Gogineni, Amy Easton, Seung-Hye Lee, Pamela Chan, Justin Elstrott
Publikováno v:
The Journal of Neuroscience
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience
TREM2 is an Alzheimer's disease (AD) risk gene expressed in microglia. To study the role of Trem2 in a mouse model of β-amyloidosis, we compared PS2APP transgenic mice versus PS2APP mice lacking Trem2 (PS2APP;Trem2ko) at ages ranging from 4 to 22 mo
Autor:
Baris Bingol, Kimberly L. Stark, Hai Ngu, Brent S. McKenzie, Donald S. Kirkpatrick, Luke Xie, Ivan Peng, Amy Easton, Erik Verschueren, Tatiana Goncharov, Eugene Varfolomeev, Keith R. Anderson, Domagoj Vucic, Meena Choi, Joshua D. Webster
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 4, Pp 1-15 (2021)
Cell Death and Disease, Vol 12, Iss 4, Pp 1-15 (2021)
RIP1 kinase-mediated inflammatory and cell death pathways have been implicated in the pathology of acute and chronic disorders of the nervous system. Here, we describe a novel animal model of RIP1 kinase deficiency, generated by knock-in of the kinas
Autor:
Janet Tao, Amy Easton, Diana Chang, Hai Ngu, Oded Foreman, Tushar Bhangale, Andrew A. Pierce, Kimberle Shen, Robert Brendza, Han Lin, Baris Bingol, Kimberly L. Stark, Brad A. Friedman
Publikováno v:
Neurobiology of Disease, Vol 159, Iss, Pp 105494-(2021)
The gene GPNMB is known to play roles in phagocytosis and tissue repair, and is upregulated in microglia in many mouse models of neurodegenerative disease as well as in human patients. Nearby genomic variants are associated with both elevated Parkins
Autor:
William J. Meilandt, Oded Foreman, Luke Xie, Christopher J. Bohlen, Brad A. Friedman, Amy Easton, Hai Ngu, David V. Hansen, Vineela D. Gandham, Richard A.D. Carano, Guita Lalehzadeh, Mitchell G. Rezzonico, Seung-Hye Lee, Kimberly L. Stark, Jose Imperio, Melanie A. Huntley, Kai H. Barck, Morgan Sheng
Publikováno v:
Neuron. 109:1283-1301.e6
Loss-of-function TREM2 mutations strongly increase Alzheimer's disease (AD) risk. Trem2 deletion has revealed protective Trem2 functions in preclinical models of β-amyloidosis, a prominent feature of pre-diagnosis AD stages. How TREM2 influences lat
Autor:
Yichin Liu, Frederick Cohen, Bei Wang, Joseph W. Lewcock, Kimberly L. Stark, Brian Dean, Young G. Shin, Arundhati Sengupta Ghosh, Kelly De La Torre, Paul Gibbons, Joseph P. Lyssikatos, Claire E. Le Pichon, Wendy Liu, Jian Wang, Michael Siu, Xingrong Liu, Snahel Patel, Malcolm P. Huestis, Han Lin, Changyou Ma, Amy Gustafson, Anthony A. Estrada, Gauri Deshmukh, Xianrui Zhao, Kimberly Scearce-Levie, Cuong Ly, Hilda Solanoy
Publikováno v:
Journal of Medicinal Chemistry. 58:401-418
Dual leucine zipper kinase (DLK, MAP3K12) was recently identified as an essential regulator of neuronal degeneration in multiple contexts. Here we describe the generation of potent and selective DLK inhibitors starting from a high-throughput screenin
Publikováno v:
Cell. 152(1-2):262-275
Summary22q11.2 microdeletions result in specific cognitive deficits and schizophrenia. Analysis of Df(16)A+/− mice, which model this microdeletion, revealed abnormalities in the formation of neuronal dendrites and spines, as well as altered brain m
Autor:
Liam Drew, Maria Karayiorgou, Florence Chaverneff, Jun Mukai, Kimberly L. Stark, Karine Fénelon, Gregg W. Crabtree, Joseph A. Gogos, Pei Ken Hsu, Sander Markx, Bin Xu
Publikováno v:
International Journal of Developmental Neuroscience. 29:259-281
Over the last fifteen years it has become established that 22q11.2 deletion syndrome (22q11DS) is a true genetic risk factor for schizophrenia. Carriers of deletions in chromosome 22q11.2 develop schizophrenia at rate of 25–30% and such deletions a
Publikováno v:
Nature. 464:763-767
Abnormalities in functional connectivity between brain areas have been postulated as an important pathophysiological mechanism underlying schizophrenia1,2. In particular, macroscopic measurements of brain activity in patients suggest that functional