Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Kimberly L. Edwards"'
Autor:
In-Kyu Lee, Ruosen Xie, Agustin Luz-Madrigal, Seunghwan Min, Jingcheng Zhu, Jiahe Jin, Kimberly L. Edwards, M. Joseph Phillips, Allison L. Ludwig, David M. Gamm, Shaoqin Gong, Zhenqiang Ma
Publikováno v:
Bioactive Materials, Vol 30, Iss , Pp 142-153 (2023)
Age-related macular degeneration (AMD) causes blindness due to loss of retinal pigment epithelium (RPE) and photoreceptors (PRs), which comprise the two outermost layers of the retina. Given the small size of the macula and the importance of direct c
Externí odkaz:
https://doaj.org/article/5fc9b60834c9465ca150b67de55a410f
Autor:
Meha Kabra, Pawan K. Shahi, Yuyuan Wang, Divya Sinha, Allison Spillane, Gregory A. Newby, Shivani Saxena, Yao Tong, Yu Chang, Amr A. Abdeen, Kimberly L. Edwards, Cole O. Theisen, David R. Liu, David M. Gamm, Shaoqin Gong, Krishanu Saha, Bikash R. Pattnaik
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Clinical genome editing is emerging for rare disease treatment, but one of the major limitations is the targeting of CRISPR editors’ delivery. We delivered base editors to the retinal pigmented epithelium (RPE) in the mouse eye using silica nanocap
Externí odkaz:
https://doaj.org/article/3120d5bf8bdb4fc3874e0562564f1672
Autor:
M. Joseph Phillips, Elizabeth E. Capowski, Andrew Petersen, Alex D. Jansen, Katherine Barlow, Kimberly L. Edwards, David M. Gamm
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Reporter lines generated in human pluripotent stem cells can be highly useful for the analysis of specific cell types and lineages in live cultures. We created the first human rod reporter line using CRISPR/Cas9 genome editing to replace one
Externí odkaz:
https://doaj.org/article/bc6bee677a18423c99acf52dbb951ec4
Autor:
Meha Kabra, Pawan K. Shahi, Yuyuan Wang, Divya Sinha, Allison Spillane, Gregory A. Newby, Shivani Saxena, Amr A. Abdeen, Kimberly L. Edwards, Cole O. Theisen, David M. Gamm, David R. Liu, Shaoqin Gong, Krishanu Saha, Bikash R. Pattnaik
Leber Congenital Amaurosis (LCA16) is a progressive vision loss disorder caused by point mutations in the KCNJ13 gene, which encodes an inward-rectifying potassium channel, Kir7.1. A nonsense mutation, W53X (c.158G>A), leads to premature truncation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce73b967956c1f0e73ae09d2ad95a92c
https://doi.org/10.1101/2022.07.12.499808
https://doi.org/10.1101/2022.07.12.499808
Autor:
Pawan K Shahi, Stephanie S. Steltzer, Cole Bacig, Evan Cory, Bikash R. Pattnaik, Sandhya Srinivasan, Divya Sinha, Kimberly L. Edwards, Katherine P. Mueller, Edwin M. Stone, Rasa Valiauga, Viswesh Periyasamy, Krishanu Saha, Benjamin Steyer, David M. Gamm, Sushmita Roy, Amr A. Abdeen, Budd A. Tucker, Alireza Fotuhi Siahpirani
Publikováno v:
Am J Hum Genet
Dominantly inherited disorders are not typically considered to be therapeutic candidates for gene augmentation. Here, we utilized induced pluripotent stem cell-derived retinal pigment epithelium (iPSC-RPE) to test the potential of gene augmentation t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ec4d7bfb4af3248439e7ef77e2375eb
https://doi.org/10.1016/j.ajhg.2020.06.011
https://doi.org/10.1016/j.ajhg.2020.06.011
Autor:
Jiang Qian, M. Joseph Phillips, Jie Wang, Alex D. Jansen, Cynthia A. Berlinicke, David M. Gamm, Donald J. Zack, Tza-Huei Wang, Eric A. Pierce, Kimberly L. Edwards, Liben Chen, Elizabeth E. Capowski, Aniruddha M. Kaushik, Alyssa Kallman
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Communications Biology
BASE-Bielefeld Academic Search Engine
Communications Biology
BASE-Bielefeld Academic Search Engine
Photoreceptor loss is a leading cause of blindness, but mechanisms underlying photoreceptor degeneration are not well understood. Treatment strategies would benefit from improved understanding of gene-expression patterns directing photoreceptor devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c62e6b92c88bab1666351f1e503971
http://link.springer.com/article/10.1038/s42003-020-0808-5
http://link.springer.com/article/10.1038/s42003-020-0808-5
Autor:
Edwin M. Stone, Rasa Valiauga, Sushmita Roy, Alireza Fotuhi Siahpirani, Kimberly L. Edwards, Bikash R. Pattnaik, Stephanie S. Steltzer, David M. Gamm, Amr A. Abdeen, Sandhya Srinivasan, Viswesh Periyasamy, Budd A. Tucker, Pawan K Shahi, Benjamin Steyer, Divya Sinha, Katherine P. Mueller, Cole Bacig, Evan Cory, Krishanu Saha
Dominantly inherited disorders are not typically considered therapeutic candidates for gene augmentation. Here, we utilized patient-specific induced pluripotent stem cell-derived retinal pigment epithelium (iPSC-RPE) to test the potential of gene aug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968cd697af5d891d2c23705f0caf5214
https://doi.org/10.1101/796581
https://doi.org/10.1101/796581
Autor:
Amr A. Abdeen, Katherine P. Mueller, Sandhya Srinivasan, Kimberly L. Edwards, Pawan K Shahi, Divya Sinha, Cole Bacig, Alireza Fotuhi Siahpirani, Bikash R. Pattnaik, Evan Cory, Rasa Valiauga, David M. Gamm, Krishanu Saha, Sushmita Roy, Benjamin Steyer, Viswesh Periyasamy, Stephanie S. Steltzer
Publikováno v:
SSRN Electronic Journal.
Dominantly inherited disorders are not typically considered therapeutic candidates for gene augmentation (GA). We tested whether GA or genome editing (GE) could serve as a solo therapy for autosomal dominant Best disease (adBD), a macular dystrophy l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4349b521501adb63b5879cb765880f3
https://doi.org/10.2139/ssrn.3377258
https://doi.org/10.2139/ssrn.3377258
Autor:
Katherine Barlow, Anna Hagstrom, Xitiz Chamling, Melissa C. Skala, Isabel Pinilla, Lindsey D. Jager, Sara E. Howden, Elizabeth E. Capowski, M. Joseph Phillips, Valentin M. Sluch, Jishnu Saha, David M. Gamm, Alex D. Jansen, Donald J. Zack, Kayvan Samimi, Steven Mayerl, Kimberly L. Edwards, Zachary Erlichman, Rasa Valiauga, Divya Sinha
Publikováno v:
Development (Cambridge, England). 146(1)
Numerous protocols have been described that produce neural retina from human pluripotent stem cells (hPSCs), many of which are based on the culture of 3D organoids. While nearly all such methods yield at least partial segments of highly mature-appear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac881f901fd1a63ade7a3d910768eb50
https://pubmed.ncbi.nlm.nih.gov/30567931
https://pubmed.ncbi.nlm.nih.gov/30567931
Autor:
Katherine Barlow, David M. Gamm, Elizabeth E. Capowski, Andrew J. Petersen, Alex D. Jansen, Kimberly L. Edwards, M. Joseph Phillips
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Reporter lines generated in human pluripotent stem cells can be highly useful for the analysis of specific cell types and lineages in live cultures. We created the first human rod reporter line using CRISPR/Cas9 genome editing to replace one allele o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4f31ac6984f72f9ad4d7bf4db0eae4
https://pubmed.ncbi.nlm.nih.gov/29402929
https://pubmed.ncbi.nlm.nih.gov/29402929