Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Kimberly L Matthews"'
Autor:
Leticia Toledo-Sherman, Catherine M. O'Connell, Christopher John Yarnold, Michael Prime, Suganathan Selvaratnam, Ignacio Munoz-Sanjuan, Ladislav Mrzljak, Arash Rassoulpour, Kimberly L Matthews, Patricia Wheelan, Laura Reed, Wolfgang Reindl, Alan Beresford, Estelle Hamelin-Flegg, Derek Alexander Weddell, William L. Mitchell, Dawn Yates, Maria Beconi, Weslyn Ward Friley, Christopher John Brown, Christin Winkler, Stephen Martin Courtney, Valerie Kempf, John Wityak, Naomi Went, Celia Dominguez, Isabell Cardaun, Kendall D. Powell, Ulrike Dijkman, Peter Johnson, Frederick Arthur Brookfield, Dirk Winkler, De Aguiar Pena Paula C, Kathy Lyons
Publikováno v:
Journal of medicinal chemistry. 58(3)
We report on the development of a series of pyrimidine carboxylic acids that are potent and selective inhibitors of kynurenine monooxygenase and competitive for kynurenine. We describe the SAR for this novel series and report on their inhibition of K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699f24106f0a18d2d3d4ac5e1d3ff8ca
https://pubmed.ncbi.nlm.nih.gov/25590515
https://pubmed.ncbi.nlm.nih.gov/25590515
Autor:
Rebecca E. Jarvis, David F. Fischer, Dawn Yates, George McAllister, Kate Barnes, Hugh Vater, L Perla Breccia, Jennipher Bate, Grant Wilshart, Kimberly L Matthews, Ignacio Munoz-Sanjuan, Celia Dominguez, Leticia Toledo-Sherman, Wesley Blackaby, Vad Lazari, Steve Martin, Mark Rose, Roger Chachope
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 87:A96.2-A96
Emerging evidence shows that the ATM signalling pathway is dysregulated in neurodegenerative disorders including Huntington’s disease (HD). ATM signalling has been shown to be elevated in cells derived from HD patients and mouse models of HD. Genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad3d08af85590cb66cafff169b8ffffe
https://doi.org/10.1136/jnnp-2016-314597.274
https://doi.org/10.1136/jnnp-2016-314597.274