Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kimberly Kajihara"'
Autor:
Volker Schellenberger, David Fischer, Bing Zheng, Thomas H. Pillow, Amrita V. Kamath, Carl Ng, Jan Marik, Corinna Lei, Dorothea Reilly, Shabkhaiz Masih, Kelly M. Loyet, Vladimir N. Podust, Kimberly Kajihara, Maciej Paluch, Andrew Polson, Gail Dianne Phillips, Summer Park, Luna Liu, Morisaki John Hiroshi, Kai Zheng, Guangmin Li, Dian Su, Douglas D. Leipold, Josefa Chuh, Victor Yip, Emily Dong, Shang-Fan Yu, Wouter L. W. Hazenbos, Jack Sadowsky, Geoffrey Del Rosario, Rebecca K. Rowntree, Jeff N. Tinianow, Neelie Zacharias, Min Xu, William S. Sawyer, Katherine R. Kozak, Hilda Hernandez-Barry, Jintang He, Cong Wu, Keyang Xu, Ben-Quan Shen
Antibody-drug conjugates (ADCs) enable cell-specific delivery of small molecules and are validated anti-cancer therapeutics. One factor limiting ADC advancement and broader application is the drug-to-antibody ratio (DAR), which dictates the number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7d05e7d54cc2ba403b546592bdee064
https://doi.org/10.21203/rs.3.rs-356231/v1
https://doi.org/10.21203/rs.3.rs-356231/v1
Autor:
Kimberly Kajihara, Patrick J. Lupardus, Sanjeev Mariathasan, Rina Fong, Matthew T. Chen, Isidro Hötzel, Wouter L. W. Hazenbos
Publikováno v:
mAbs
Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are a growing health threat worldwide. Efforts to identify novel antibodies that target S. aureus cell surface antigens are a promising direction in the development of antibiotic
Autor:
Leanna Staben, Klaus Koefoed, Helga Raab, Cecile Chalouni, Yana Khalfin, Laura DePalatis, Kelly M. Loyet, Thomas H. Pillow, Min Xu, Byoung-Chul Lee, Peter S. Andersen, Emile Plise, Janice Kim, Elizabeth Luis, Martine Darwish, Rina Fong, Man-Wah Tan, Eric J. Brown, Patrick J. Lupardus, J. Hiroshi Morisaki, Summer Park, Sophie M. Lehar, Donghong Yan, Richard Vandlen, Joseph P. Lyssikatos, Magnus Strandh, Wouter L. W. Hazenbos, John A. Flygare, Sanjeev Mariathasan, Kimberly Kajihara, Hilda Hernandez, Jonathan Cheong
Publikováno v:
Nature. 527:323-328
Staphylococcus aureus is considered to be an extracellular pathogen. However, survival of S. aureus within host cells may provide a reservoir relatively protected from antibiotics, thus enabling long-term colonization of the host and explaining clini
Autor:
Jing Kang, Robert Mintzer, Kimberly Kajihara, Wouter L. W. Hazenbos, Shailesh V. Date, Peter A. S. Smith, J. Hiroshi Morisaki, Eric M. Kofoed, Man-Wah Tan, Eric J. Brown, Tommy K. Cheung, Donghong Yan, Chau Linda Truong, David Arnott, Ishita M. Shah, Michael F. T. Koehler, Zora Modrusan, Min Xu, Christopher E. Heise
Publikováno v:
mBio, Vol 7, Iss 5 (2016)
Microbial Cell
mBio, Vol 7, Iss 5, p e00412-16 (2016)
mBio
Microbial Cell
mBio, Vol 7, Iss 5, p e00412-16 (2016)
mBio
The type I signal peptidase of Staphylococcus aureus, SpsB, is an attractive antibacterial target because it is essential for viability and extracellularly accessible. We synthesized compound 103, a novel arylomycin-derived inhibitor of SpsB with sig
Autor:
Hiroshi Morisaki, Jayanta Debnath, Elsa-Noah N’Diaye, Ivy Hsieh, Eric J. Brown, Kimberly Kajihara
Publikováno v:
EMBO reports. 10:173-179
Ubiquilins (UBQLNs) are adaptor proteins thought to deliver ubiquitinated substrates to proteasomes. Here, we show a role for UBQLN in autophagy: enforced expression of UBQLN protects cells from starvation-induced death, whereas depletion of UBQLN re
Publikováno v:
Infection and Immunity. 74:1757-1767
The ability to invade and grow in macrophages is necessary for Mycobacterium tuberculosis to cause disease. We have found a Mycobacterium marinum locus of two genes that is required for both invasion and intracellular survival in macrophages. The gen
Autor:
Klaus Koefoed, J. Hiroshi Morisaki, Angela Oh, Mark J. Kwakkenbos, Arjen Q. Bakker, Christopher M. Koth, Binh An Diep, Satish Ramakrishnan, Sanjeev Mariathasan, Hergen Spits, Janice Kim, Tao Sai, Man-Wah Tan, Tim Beaumont, Yana Khalfin, Min Xu, Sophie M. Lehar, S. Jack Lin, Byoung-Chul Lee, Eric J. Brown, Peter S. Andersen, Lee R. Swem, Ishita M. Shah, Andrew Sebrell, Kimberly Kajihara, Richard Vandlen, Magnus Strandh, Wouter L. W. Hazenbos, Qui Phung
Publikováno v:
PLoS pathogens, 9(10). Public Library of Science
PLoS Pathogens, Vol 9, Iss 10, p e1003653 (2013)
PLoS Pathogens
PLoS Pathogens, Vol 9, Iss 10, p e1003653 (2013)
PLoS Pathogens
Infection of host tissues by Staphylococcus aureus and S. epidermidis requires an unusual family of staphylococcal adhesive proteins that contain long stretches of serine-aspartate dipeptide-repeats (SDR). The prototype member of this family is clump
Autor:
Kimberly Kajihara, Mark von Zastrow, Aylin C. Hanyaloglu, Elsa-Noah N’Diaye, Manojkumar A. Puthenveedu, Ping Wu, Eric J. Brown
The activity of many signaling receptors is regulated by their endocytosis via clathrin-coated pits (CCPs). For G protein-coupled receptors (GPCRs), recruitment of the adaptor protein arrestin to activated receptors is thought to be sufficient to dri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a517bfb935b03eafc4c40b41ca4b5bf
Publikováno v:
Journal of cellular physiology. 205(2)
CD47 is a ubiquitously expressed plasma membrane protein, also known as Integrin Associated Protein, that modulates cell adhesion both through alteration of the avidity of integrin binding and through interaction with its own ligands, the extracellul