Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice

Autor: Kimberly K. Richardson, Gareeballah Osman Adam, Wen Ling, Aaron Warren, Adriana Marques-Carvalho, Jeff D. Thostenson, Kimberly Krager, Nukhet Aykin-Burns, Stephanie D. Byrum, Maria Almeida, Ha-Neui Kim

Publikováno v: Molecular Metabolism, Vol 88, Iss , Pp 102012- (2024)

Objectives: The mitochondrial deacetylase sirtuin-3 (SIRT3) is necessary for the increased bone resorption and enhanced function of mitochondria in osteoclasts that occur with advancing age; how SIRT3 drives bone resorption remains elusive. Methods:

Externí odkaz: https://doaj.org/article/b1c37c9a2bd346bf8f32edeea3efc5b8

Hematopoietic Cytoplasmic Adaptor Protein Hem1 Promotes Osteoclast Fusion and Bone Resorption in Mice

Autor: Xiaoyan Wang, Lijian Shao, Kimberly K. Richardson, Wen Ling, Aaron Warren, Kimberly Krager, Nukhet Aykin-Burns, Robert Hromas, Daohong Zhou, Maria Almeida, Ha-Neui Kim

Publikováno v: The Journal of biological chemistry.

Hem1 (Hematopoietic protein 1), a hematopoietic cell-specific member of the Hem family of cytoplasmic adaptor proteins, is essential for lymphopoiesis and innate immunity, as well as for the transition of hematopoiesis from the fetal liver to the bon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4b7cbc06ecaec087f599a7d378f3d8
https://pubmed.ncbi.nlm.nih.gov/36574841

Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice

Autor: Kimberly K. Richardson, Kimberly J. Krager, Nukhet Aykin-Burns, Pilar Simmons, Ha-Neui Kim, Wen Ling, Antiño R. Allen

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 11711, p 11711 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 21

Space is a high-stress environment. One major risk factor for the astronauts when they leave the Earth’s magnetic field is exposure to ionizing radiation from galactic cosmic rays (GCR). Several adverse changes occur in mammalian anatomy and physio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8810bf43447d133f9487f16b08701ee4
https://www.mdpi.com/1422-0067/22/21/11711

Sex and pairing status explain variations in the activation of nonapeptide receptors in song and motivation regions

Autor: Kimberly K. Richardson, Kyle J. Mann, Michelle L. Tomaszycki

Publikováno v: Behavioral neuroscience. 130(5)

The nonapeptides oxytocin and vasopressin have been implicated in a variety of social behaviors. In zebra finches, oxytocin antagonists decrease pairing in both sexes, and pairing, in turn, increases expression of both mesotocin (the avian homologue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99df4dd8fe52a2ad68e7687da982f316
https://pubmed.ncbi.nlm.nih.gov/27504854

Systematic symptom management in the IMPACT Consortium: rationale and design for 3 effectiveness-implementation trials.

Autor: Smith AW; Outcomes Research Branch, Healthcare Delivery Research Program, National Cancer Institute, Bethesda, MD, USA., DiMartino L; Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Austin, TX, USA.; RTI International, Washington, DC, USA., Garcia SF; Department of Medical Social Sciences and the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Mitchell SA; Outcomes Research Branch, Healthcare Delivery Research Program, National Cancer Institute, Bethesda, MD, USA., Ruddy KJ; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Smith JD; Division of Health Systems Innovation and Research, Department of Population Health Sciences, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, USA., Wong SL; Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA., Cahue S; American Academy of Allergy, Asthma and Immunology, Chicago, IL, USA., Cella D; Department of Medical Social Sciences and the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Jensen RE; Outcomes Research Branch, Healthcare Delivery Research Program, National Cancer Institute, Bethesda, MD, USA., Hassett MJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Hodgdon C; Guiding Researchers and Advocates to Scientific Partnerships, Baltimore, MD, USA., Kroner B; RTI International, Washington, DC, USA., Osarogiagbon RU; Multidisciplinary Thoracic Oncology Program, Baptist Cancer Center, Memphis, TN, USA., Popovic J; Value Evidence and Outcomes, GSK, Waltham, MA, USA., Richardson K; Black Cancer Collaborative, Chicago, IL, USA., Schrag D; Department of Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Cheville AL; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.

Publikováno v: JNCI cancer spectrum [JNCI Cancer Spectr] 2023 Oct 31; Vol. 7 (6).