Zobrazeno 1 - 10
of 231
pro vyhledávání: '"Kimberly K. Leslie"'
Autor:
Craig M. Rush, Zannel Blanchard, Jacob T. Polaski, Kyle S. Osborne, Krystle Osby, Jeffery M. Vahrenkamp, Chieh-Hsiang Yang, David H. Lum, Christy R. Hagan, Kimberly K. Leslie, Miles A. Pufall, Kristina W. Thiel, Jason Gertz
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Most endometrial cancers express the hormone receptor estrogen receptor alpha (ER) and are driven by excess estrogen signaling. However, evaluation of the estrogen response in endometrial cancer cells has been limited by the availability of
Externí odkaz:
https://doaj.org/article/aac81ba3c33c4f1da08291f62bda8d89
Autor:
Garima Dixit, Jesus Gonzalez‐Bosquet, Joseph Skurski, Eric J. Devor, Erin B. Dickerson, Warren B. Nothnick, Priya D. Issuree, Kimberly K. Leslie, Thorsten Maretzky
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 5, Pp n/a-n/a (2023)
Abstract Background Mutations in the receptor tyrosine kinase gene fibroblast growth factor receptor 2 (FGFR2) occur at a high frequency in endometrial cancer (EC) and have been linked to advanced and recurrent disease. However, little is known about
Externí odkaz:
https://doaj.org/article/e1ddfbedbc6649e691ed24abee9aaa3f
Autor:
Jianling Bi, Yuping Zhang, Paige K. Malmrose, Haley A. Losh, Andreea M. Newtson, Eric J. Devor, Kristina W. Thiel, Kimberly K. Leslie
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-10 (2022)
Abstract Histone deacetylase (HDAC) inhibitors and proteasome inhibitors have been approved by the FDA for the treatment of multiple myeloma and lymphoma, respectively, but have not achieved similar activity as single agents in solid tumors. Preclini
Externí odkaz:
https://doaj.org/article/22755d59f786409eb791c68e2d8e5ad7
Autor:
Jesus Gonzalez Bosquet, Eric J. Devor, Andreea M. Newtson, Brian J. Smith, David P. Bender, Michael J. Goodheart, Megan E. McDonald, Terry A. Braun, Kristina W. Thiel, Kimberly K. Leslie
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Nearly a third of patients with high-grade serous ovarian cancer (HGSC) do not respond to initial therapy and have an overall poor prognosis. However, there are no validated tools that accurately predict which patients will not respond. Our
Externí odkaz:
https://doaj.org/article/f68931067a254b7db52a837c8291c2da
Autor:
Eric J. Devor, Brandon M. Schickling, Jace R. Lapierre, David P. Bender, Jesus Gonzalez-Bosquet, Kimberly K. Leslie
Publikováno v:
Pharmaceuticals, Vol 14, Iss 9, p 942 (2021)
Elevated expression of placenta-specific protein 1 (PLAC1) is associated with the increased proliferation and invasiveness of a variety of human cancers, including ovarian cancer. Recent studies have shown that the tumor suppressor p53 directly suppr
Externí odkaz:
https://doaj.org/article/5e27e07441e14791ae4d52403dc2c939
Autor:
Jianling Bi, Garima Dixit, Yuping Zhang, Eric J. Devor, Haley A. Losh, Andreea M. Newtson, Kristen L. Coleman, Donna A. Santillan, Thorsten Maretzky, Kristina W. Thiel, Kimberly K. Leslie
Publikováno v:
Pharmaceuticals, Vol 14, Iss 7, p 682 (2021)
Angiogenesis plays a crucial role in tumor development and metastasis. Both bevacizumab and cediranib have demonstrated activity as single anti-angiogenic agents in endometrial cancer, though subsequent studies of bevacizumab combined with chemothera
Externí odkaz:
https://doaj.org/article/b00a64b6198e48c4b43780cdc49369ac
Autor:
Adriann M. Hovey, Eric J. Devor, Patrick J. Breheny, Sarah L. Mott, Donghai Dai, Kristina W. Thiel, Kimberly K. Leslie
Publikováno v:
Translational Oncology, Vol 8, Iss 2, Pp 85-96 (2015)
Cancer-testis (CT) antigens are a large family of genes that are selectively expressed in human testis germ cells, overexpressed in a variety of tumors and predominantly located on the X chromosome. To date, all known CT antigens are protein-coding g
Externí odkaz:
https://doaj.org/article/ed54ef008e0d4b50b271743fed8ca0e2
Publikováno v:
Diseases, Vol 2, Iss 3, Pp 209-225 (2014)
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies due to underlying co-morbid cirrhosis and chemo-resistance. Vaccination and improved treatment for hepatitis are the most effective means to reduce the burden of liver cancer world
Externí odkaz:
https://doaj.org/article/699041e2fc6d4caeaa6fe56779a4419a
Autor:
Eric J. Devor, Henry D. Reyes, Donna A. Santillan, Mark K. Santillan, Chinenye Onukwugha, Michael J. Goodheart, Kimberly K. Leslie
Publikováno v:
Obstetrics and Gynecology International, Vol 2014 (2014)
Placenta-specific protein 1 (PLAC1) is a secreted protein found in trophoblasts. Several reports implicate a central role for PLAC1 in establishment and maintenance of the placenta. In addition to placentae PLAC1 is expressed in a variety of solids i
Externí odkaz:
https://doaj.org/article/a9aaced819b449d3b46c9c99f6995a8d
Autor:
Robert S. McDuffie, Jill K. Davies, Kimberly K. Leslie, Scott Lee, Michael P. Sherman, Ronald S. Gibbs
Publikováno v:
Infectious Diseases in Obstetrics and Gynecology, Vol 9, Iss 4, Pp 233-237 (2001)
Objective: To determinewhether treatment with interleukin-1 receptor antagonist (IL1-ra) would affect amniotic fluid concentrations of tumor necrosis factor alpha (TNF-α) and prostaglandins or clinical or microbiological outcomes in a model of ascen
Externí odkaz:
https://doaj.org/article/a5b72c9ad5dd4f738d1941b8e8471169