Comparison of the pharmacology of hydroxamate- and carboxylate-based matrix metalloproteinase inhibitors (MMPIs) for the treatment of osteoarthritis

Autor: Timothy R. Baker, Biswanath De, Michael J. Janusz, Sandra A. Heitmeyer, Stanislaw Pikul, Neil Gregory Almstead, Michael George Natchus, Y.O. Taiwo, Vikram S. Patel, Sean X. Peng, Kimberly K. Brown, E.B. Hookfin, Lily C. Hsieh

Publikováno v: Inflammation Research. 55:60-65

Objective and Design: Hydroxamic-and carboxylic- acid based matrix metalloproteinase inhibitors (MMPIs) were compared for their potency against various MMPs, pharmacodynamic properties and in vivo efficacy in a model of cartilage degeneration. Materi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a929852435ec2512304b9a6330b90405
https://doi.org/10.1007/s00011-005-0014-4

The development of novel inhibitors of tumor necrosis factor-α (TNF-α) production based on substituted [5,5]-bicyclic pyrazolones

Autor: John C. VanRens, Adam Golebiowski, Matthew J. Laufersweiler, Lily C. Hsieh, Steven K. Laughlin, Biswanath De, Todd A. Brugel, Marlene Mekel, Michael J. Janusz, Townes Jennifer Anne, Roger G. Bookland, Karen Juergens, R.L. Walter, Sandra A. Heitmeyer, Kimberly K. Brown, Mark Sabat, Michael P. Clark

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 14:4267-4272

Novel substituted [5,5]-bicyclic pyrzazolones are presented as inhibitors of tumor necrosis factor-alpha (TNF-alpha) production. Many of these compounds show low nanomolar activity against lipopolysaccaride (LPS)-induced TNF-alpha production in THP-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175790dc397863d0c9c125c5e392f266
https://doi.org/10.1016/j.bmcl.2004.06.001

P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis

Autor: Yetunde Olabisi Taiwo, Kimberly K. Brown, Michael J. Janusz, Lily C. Hsieh, Maria Buchalova, E.B. Hookfin, Sandra A. Heitmeyer

Publikováno v: Journal of Inflammation (London, England)
Journal of Inflammation, Vol 5, Iss 1, p 22 (2008)

Background Evaluate the potential role of p38 inhibitors for the treatment of osteoarthritis using an animal model of joint degeneration (iodoacetate-induced arthritis) and a pain model (Hargraeves assay). Methods P38 kinase activity was evaluated in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a561565b215e050212dcb992d87ad5
https://doi.org/10.1186/1476-9255-5-22

Induction of osteoarthritis in the rat by surgical tear of the meniscus: Inhibition of joint damage by a matrix metalloproteinase inhibitor

Autor: A.M. Bendele, Michael J. Janusz, Kimberly K. Brown, Lily C. Hsieh, Sandra A. Heitmeyer, Y.O. Taiwo

Publikováno v: Osteoarthritis and cartilage. 10(10)

Objective Characterize a model of osteoarthritis (OA) induced by a surgically transecting the medial collateral ligament and meniscus. Evaluate the effectiveness of a matrix metalloproteinase (MMP) inhibitor in this model. Methods The medial collater

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f685d88557376ab699720234f5f22fb0
https://pubmed.ncbi.nlm.nih.gov/12359164

Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (ICECAP): study protocol for a multicenter, randomized, adaptive allocation clinical trial to identify the optimal duration of induced hypothermia for neuroprotection in comatose, adult survivors of after out-of-hospital cardiac arrest.

Autor: Meurer WJ; Emergency Medicine, Neurology, University of Michigan, TC B1-354, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109-5301, USA. wmeurer@med.umich.edu., Schmitzberger FF; Emergency Medicine, University of Michigan, Ann Arbor, MI, USA., Yeatts S; Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA., Ramakrishnan V; Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA., Abella B; Emergency Medicine, University of Pennsylvania, Philadelphia, PA, USA., Aufderheide T; Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI, USA., Barsan W; Emergency Medicine, University of Michigan, Ann Arbor, MI, USA., Benoit J; Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA., Berry S; Berry Consultants, Austin, TX, USA., Black J; Emergency Medicine, Neuroscience, University of Michigan, Thermo Fisher Scientific, Ann Arbor, MI, USA., Bozeman N; Emergency Medicine, University of Michigan, Ann Arbor, MI, USA., Broglio K; Berry Consultants, Oncology Statistical Innovation, Gaithersburg, MD, USA., Brown J; National Institutes of Health, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Brown K; Emergency Medicine, University of Michigan, Ann Arbor, MI, USA., Carlozzi N; Physical Medicine and Rehabilitation, Surgery, University of Michigan, Ann Arbor, MI, USA., Caveney A; Emergency Medicine, University of Michigan, Ann Arbor, MI, USA., Cho SM; Critical Care Medicine, Johns Hopkins Hospital, Anesthesia, Baltimore, MD, USA., Chung-Esaki H; The Queen's Medical Center, University of Hawaii John A. Burns School of Medicine, Critical Care, Honolulu, HI, USA., Clevenger R; Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA., Conwit R; Neurology, Indiana University, Indianapolis, IN, USA., Cooper R; Emergency Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA., Crudo V; Emergency Medicine, University of Michigan, Ann Arbor, MI, USA., Daya M; Emergency Medicine, Oregon Health & Science University, Portland, OR, USA., Harney D; Emergency Medicine, University of Michigan, Ann Arbor, MI, USA., Hsu C; Emergency Medicine, University of Michigan, Ann Arbor, MI, USA., Johnson NJ; Emergency Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Medicine, University of Washington, Seattle, WA, USA., Khan I; Neurology, University of Rochester Medical Center, Rochester, NY, USA., Khosla S; Emergency Medicine, University of Illinois Chicago, Chicago, IL, USA., Kline P; Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA., Kratz A; Physical Medicine and Rehabilitation, Surgery, University of Michigan, Ann Arbor, MI, USA., Kudenchuk P; Division of Cardiology, Medicine, University of Washington, Seattle, WA, USA., Lewis RJ; Emergency Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA., Madiyal C; Emergency Medicine, University of Michigan, Ann Arbor, MI, USA., Meyer S; Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA., Mosier J; Emergency Medicine, Medicine, University of Arizona, Tucson, AZ, USA., Mouammar M; Medicine, Critical Care Medicine, OHSU Portland Adventist Medical Center, Portland, OR, USA., Neth M; Emergency Medicine, Oregon Health & Science University, Portland, OR, USA., O'Neil B; Emergency Medicine, Wayne State University, Detroit, MI, USA., Paxton J; Emergency Medicine, Wayne State University, Detroit, MI, USA., Perez S; Emergency Medicine Research, University of Michigan, Ann Arbor, MI, USA., Perman S; Emergency Medicine, Yale School of Medicine, New Haven, CT, USA., Sozener C; Emergency Medicine, University of Michigan, Ann Arbor, MI, USA., Speers M; Emergency Medicine, University of Michigan, Ann Arbor, MI, USA., Spiteri A; Emergency Medicine, University of Michigan, Ann Arbor, MI, USA., Stevenson V; Emergency Medicine, University of Michigan, Ann Arbor, MI, USA., Sunthankar K; Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA., Tonna J; Surgery, University of Utah Health, Salt Lake City, UT, USA., Youngquist S; Emergency Medicine, Spencer Eccles School of Medicine at the University of Utah, Salt Lake City, UT, USA., Geocadin R; Neurology, Anesthesiology-Critical Care Medicine, Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Silbergleit R; Emergency Medicine, University of Michigan, Ann Arbor, MI, USA.

Publikováno v: Trials [Trials] 2024 Jul 23; Vol. 25 (1), pp. 502. Date of Electronic Publication: 2024 Jul 23.