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of 22
pro vyhledávání: '"Kimberly J. McCabe"'
Autor:
Kimberly J. McCabe
This open access volume compiles student reports from the 2022 Simula Summer School in Computational Physiology. The reports provide an overview of some tools available to model physiology in excitable tissues across scales and scientific questions.
Autor:
Kimberly J. McCabe
This open access volume compiles student reports from the 2021 Simula Summer School in Computational Physiology. Interested readers will find herein a number of modern approaches to modeling excitable tissue. This should provide a framework for tools
Autor:
María Hernández Mesa, Jonas van den Brink, William E Louch, Kimberly J McCabe, Padmini Rangamani
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1010126 (2022)
Super-resolution imaging techniques have provided a better understanding of the relationship between the nanoscale organization and function of ryanodine receptors (RyRs) in cardiomyocytes. Recent data have indicated that this relationship is disrupt
Externí odkaz:
https://doaj.org/article/df3d90dff164427096382d07e609007d
Autor:
Kimberly J. McCabe, Padmini Rangamani
Publikováno v:
Journal of Molecular and Cellular Cardiology. 154:32-40
The cAMP/PKA pathway is a fundamental regulator of excitation-contraction coupling in cardiomyocytes. Activation of cAMP has a variety of downstream effects on cardiac function including enhanced contraction, accelerated relaxation, adaptive stress r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf5afcc4c3d1a3fd42cf83d97ed2749
https://doi.org/10.1016/j.yjmcc.2021.01.008
https://doi.org/10.1016/j.yjmcc.2021.01.008
Autor:
Kristen Garcia, Marcus Hock, Vikrant Jaltare, Can Uysalel, Kimberly J McCabe, Abigail Teitgen, Daniela Valdez-Jasso
Publikováno v:
Computational Physiology ISBN: 9783031051630
2-deoxy-ATP (dATP) is a myosin activator known to improve cardiac contractile force [1]. In vitro studies have shown that dATP alters the calcium transient profile in addition to the kinetics of the cross-bridge cycle [2]. Furthermore, in vivo studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e501dbe69cf961d9eea39f2e2725d25
https://doi.org/10.1007/978-3-031-05164-7_7
https://doi.org/10.1007/978-3-031-05164-7_7
Publikováno v:
Curr Opin Biomed Eng
Myocardial hypertrophy is the result of sustained perturbations to the mechanical and/or neurohormonal homeostasis of cardiac cells and is driven by integrated, multiscale biophysical and biochemical processes that are currently not well defined. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72cff9e8ff82c09c183f402fc0213dc
https://doi.org/10.1016/j.cobme.2019.09.005
https://doi.org/10.1016/j.cobme.2019.09.005
Autor:
Marcus Hock, Matthew C. Childers, Abigail E. Teitgen, Gary Huber, Kimberly J. McCabe, J. Andrew McCammon, Michael Regnier, Andrew D. McCulloch
Publikováno v:
Biophysical Journal. 121:291a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::101ed72ee4ec49c90846b622c482f05f
https://doi.org/10.1016/j.bpj.2021.11.1292
https://doi.org/10.1016/j.bpj.2021.11.1292
Autor:
Abigail E. Teitgen, Kimberly J. McCabe, Marcus Hock, Daniel A. Beard, Michael Regnier, Andrew D. McCulloch
Publikováno v:
Biophysical Journal. 121:435a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4661a616394a311f2e0777cf836f9f7a
https://doi.org/10.1016/j.bpj.2021.11.600
https://doi.org/10.1016/j.bpj.2021.11.600
Autor:
Kimberly J. McCabe, Andrew D. McCulloch, Gary A. Huber, Michael Regnier, J. Andrew McCammon, Yasser Aboelkassem
Publikováno v:
Biophysical journal, vol 117, iss 12
Biophys J
Biophys J
We use Brownian-Langevin dynamics principles to derive a coarse-graining multiscale myofilament model that can describe the thin-filament activation process during contraction. The model links atomistic molecular simulations of protein-protein intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336e5d61e85e3805e8cdc493d8ecc6b1
https://escholarship.org/uc/item/85872709
https://escholarship.org/uc/item/85872709
Autor:
Galina V. Flint, Matthew C. Childers, Chen-Ching Yuan, Kimberly J. McCabe, Jason D. Murray, Thomas C. Irving, Carla Zuzek, Valerie Daggett, Farid Moussavi-Harami, Saffie Mohran, Joseph D. Powers, Andrew D. McCulloch, Romi Castillo, Weikang Ma, Michael Regnier
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 23
The naturally occurring nucleotide 2-deoxy-adenosine 5'-triphosphate (dATP) can be used by cardiac muscle as an alternative energy substrate for myosin chemomechanical activity. We and others have previously shown that dATP increases contractile forc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5873416b8e20f3578ab7bfaf42bd3944
https://escholarship.org/uc/item/7d16d992
https://escholarship.org/uc/item/7d16d992