Výsledky vyhledávání - "Kimberly J. Canty"

Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

Autor: Beatrice Winkel, César Nombela-Arrieta, Gregory Pivarnik, Jiayun Lu, Alexei Protopopov, Kimberly J. Canty, Leslie E. Silberstein, Shin-Young Park, Brendan A.C. Harley, John E. Mahoney

Publikováno v: Nature Cell Biology. 15:533-543

The existence of a haematopoietic stem cell niche as a spatially confined regulatory entity relies on the notion that haematopoietic stem and progenitor cells (HSPCs) are strategically positioned in unique bone marrow microenvironments with defined a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6154aeb7e1eaa76d29af49e7a31d30
https://doi.org/10.1038/ncb2730

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Focal Adhesion Kinase Regulates the Localization and Retention of Pro-B Cells in Bone Marrow Microenvironments

Autor: Brendan A.C. Harley, Leslie E. Silberstein, Peter Wolfram, Kimberly J. Canty, John P. Manis, Gregory Pivarnik, Hilary E. Beggs, César Nombela-Arrieta, Shin-Young Park

Publikováno v: The Journal of Immunology. 190:1094-1102

Progenitor B cells reside in complex bone marrow (BM) microenvironments where they receive signals for growth and maturation. We reported previously that the CXCL12-focal adhesion kinase (FAK)-VLA4 pathway plays an important role in progenitor B cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb8821d24ff42e9dbec67006574c249
https://doi.org/10.4049/jimmunol.1202639

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Perivascular deletion of murine Rac reverses the ratio of marrow arterioles and sinusoid vessels and alters hematopoiesis in vivo

Autor: Shin-Young Park, Leslie E. Silberstein, David A. Williams, Ronald Mathieu, Kimberly J. Canty, Marioara F. Ciuculescu

Publikováno v: Blood. 125(20)

Hematopoietic stem cells (HSCs) are localized within specialized microenvironments throughout the BM. Nestin-expressing (Nestin(+)) mesenchymal stromal cells (MSCs) are important in the perivascular space. Rac is critical for MSC cell shape in vitro,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8b62e8cfd5755069b11e51e3dc1475
https://pubmed.ncbi.nlm.nih.gov/25824687

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Erratum: Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

Autor: Brendan A.C. Harley, César Nombela-Arrieta, Beatrice Winkel, John E. Mahoney, Kimberly J. Canty, Jiayun Lu, Shin-Young Park, Gregory Pivarnik, Leslie E. Silberstein, Alexei Protopopov

Publikováno v: Nature Cell Biology. 15:1016-1016

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::173de362f9312f58cf92dcfc2df81dd2
https://doi.org/10.1038/ncb2813

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