Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Kimberly J. Bush"'
Autor:
Anne Taylor, Charles J. Mcintyre, Christine Fandozzi, Carolyn McHale, Jillian DiMuzio, Steven Harper, Steven S. Carroll, Vincenzo Summa, Jeff Fritzen, Aileen Soriano, Marco Ferrara, Joseph J. Romano, David B. Olsen, Kevin Nguyen, Steven W. Ludmerer, Nigel J. Liverton, Robert Chase, Stuart Black, John W. Butcher, Kevin F. Gilbert, Qian Huang, Michael T. Rudd, Adam Gates, Paul J. Coleman, Marcello DiFilippo, Mark Stahlhut, Kimberly J. Bush, John Swestock, Nicole Trainor, Christine Burlein, Stephanie McClain, John A. McCauley, M. Katharine Holloway, Donald J. Graham
Publikováno v:
ChemMedChem. 10:727-735
With the goal of identifying inhibitors of hepatitis C virus (HCV) NS3/4a protease that are potent against a wide range of genotypes and clinically relevant mutant viruses, several subseries of macrocycles were investigated based on observations made
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e23e37fb44618a041512672388b2e3
https://doi.org/10.1002/cmdc.201402558
https://doi.org/10.1002/cmdc.201402558
Autor:
John A. McCauley, Kevin Nguyen, Anne Taylor, Joseph J. Romano, Steven S. Carroll, Nicole Trainor, Qian Huang, Stephanie McClain, M. Katharine Holloway, Joseph P. Vacca, Jillian DiMuzio, Christine Burlein, Christine Fandozzi, Carolyn McHale, Vincenzo Summa, Michael Rowley, John W. Butcher, Nigel J. Liverton, Charles J. Mcintyre, Adam Gates, Bang-Lin Wan, Michael T. Rudd, Donald J. Graham, Steven Harper, David B. Olsen, Terry A. Lyle, Kevin F. Gilbert, Mark Stahlhut, Kimberly J. Bush, Steven W. Ludmerer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7207-7213
A series of macrocyclic compounds containing a cyclic constraint in the P2–P4 linker region have been discovered and shown to exhibit excellent HCV NS3/4a genotype 3a and genotype 1b R155 K, A156T, A156 V, and D168 V mutant activity while maintaini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddb557fdc755adc3a67b410d163da85
https://doi.org/10.1016/j.bmcl.2012.09.061
https://doi.org/10.1016/j.bmcl.2012.09.061
Autor:
John Swestock, Christine Fandozzi, John A. McCauley, Nicole Trainor, Bang-Lin Wan, M. Katharine Holloway, Donald J. Graham, Charles J. Mcintyre, Nigel J. Liverton, Joseph J. Romano, Michael T. Rudd, John W. Butcher, Steven S. Carroll, Mark Stahlhut, Kevin F. Gilbert, Jillian DiMuzio, David B. Olsen, Steven W. Ludmerer, Kimberly J. Bush, Kevin Nguyen, Joseph P. Vacca
Publikováno v:
ACS Medicinal Chemistry Letters. 2:207-212
The discovery of MK-1220 is reported along with the development of a series of HCV NS3/4A protease inhibitors containing a P2 to P4 macrocyclic constraint with improved preclinical pharmacokinetics. Optimization of the P2 heterocycle substitution pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b87d35ae01567431ecab1fba89870b
https://doi.org/10.1021/ml1002426
https://doi.org/10.1021/ml1002426
Autor:
Nicole Trainor, Christine Fandozzi, Kevin F. Gilbert, Joseph J. Romano, Bang-Lin Wan, Shi-Shan Mao, John Swestock, John A. McCauley, M. Katharine Holloway, David B. Olsen, Nigel J. Liverton, Kimberly J. Bush, Donald J. Graham, Mark Stahlhut, Steven S. Carroll, John W. Butcher, Steven W. Ludmerer, Michael T. Rudd, Jillian DiMuzio, Kevin Nguyen, Joseph P. Vacca, Charles J. Mcintyre
Publikováno v:
Journal of Medicinal Chemistry. 53:2443-2463
A new class of HCV NS3/4a protease inhibitors which contain a P2 to P4 macrocyclic constraint was designed using a molecular-modeling derived strategy. Exploration of the P2 heterocyclic region, the P2 to P4 linker, and the P1 side chain of this clas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca278167f94eed395382711e9a327f60
https://doi.org/10.1021/jm9015526
https://doi.org/10.1021/jm9015526