Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Kimberly J Skuster"'
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Akademický článek
Building the vertebrate codex using the gene breaking protein trap library
Autor: Noriko Ichino, MaKayla R Serres, Rhianna M Urban, Mark D Urban, Anthony J Treichel, Kyle J Schaefbauer, Lauren E Tallant, Gaurav K Varshney, Kimberly J Skuster, Melissa S McNulty, Camden L Daby, Ying Wang, Hsin-kai Liao, Suzan El-Rass, Yonghe Ding, Weibin Liu, Jennifer L Anderson, Mark D Wishman, Ankit Sabharwal, Lisa A Schimmenti, Sridhar Sivasubbu, Darius Balciunas, Matthias Hammerschmidt, Steven Arthur Farber, Xiao-Yan Wen, Xiaolei Xu, Maura McGrail, Jeffrey J Essner, Shawn M Burgess, Karl J Clark, Stephen C Ekker
Publikováno v: eLife, Vol 9 (2020)
One key bottleneck in understanding the human genome is the relative under-characterization of 90% of protein coding regions. We report a collection of 1200 transgenic zebrafish strains made with the gene-break transposon (GBT) protein trap to simult
Externí odkaz: https://doaj.org/article/304fac055ae14ae1937ee0f79c8cd7bc
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2
Akademický článek
Protein-Trap Insertional Mutagenesis Uncovers New Genes Involved in Zebrafish Skin Development, Including a Neuregulin 2a-Based ErbB Signaling Pathway Required during Median Fin Fold Morphogenesis.
Autor: Stephanie E Westcot, Julia Hatzold, Mark D Urban, Stefânia K Richetti, Kimberly J Skuster, Rhianna M Harm, Roberto Lopez Cervera, Noriko Umemoto, Melissa S McNulty, Karl J Clark, Matthias Hammerschmidt, Stephen C Ekker
Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0130688 (2015)
Skin disorders are widespread, but available treatments are limited. A more comprehensive understanding of skin development mechanisms will drive identification of new treatment targets and modalities. Here we report the Zebrafish Integument Project
Externí odkaz: https://doaj.org/article/dfc5ce77986844aea90c9a01f34a988b
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5
A transgenic zebrafish model for monitoring glucocorticoid receptor activity
Autor: Randall G. Krug, Karl J. Clark, Tanya L. Poshusta, Samantha L. Gardner, Kimberly J. Skuster, MaKayla R. Berg
Publikováno v: Genes, Brain and Behavior. 13:478-487
Gene regulation resulting from glucocorticoid receptor and glucocorticoid response element interactions is a hallmark feature of stress response signaling. Imbalanced glucocorticoid production and glucocorticoid receptor activity have been linked to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ffa2956baec8f4b1d6249666ac7fb017
https://doi.org/10.1111/gbb.12135
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6
Active recombinant Tol2 transposase for gene transfer and gene discovery applications
Autor: David Nelsen, Jun Ni, Mark D. Urban, Darius Balciunas, Kirk J. Wangensteen, Kimberly J. Skuster, Stephen C. Ekker
Publikováno v: Mobile DNA
Background The revolutionary concept of “jumping genes” was conceived by McClintock in the late 1940s while studying the Activator/Dissociation (Ac/Ds) system in maize. Transposable elements (TEs) represent the most abundant component of many euk
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94a87174de872dfc2d6e2a02537c5e2
https://pubmed.ncbi.nlm.nih.gov/27042235
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7
in vivo protein trapping produces a functional expression codex of the vertebrate proteome
Autor: Darius Balciunas, Mark D. Urban, Karl J. Clark, Hans Martin Pogoda, Ashok Patowary, Stephen C. Ekker, Aubrey L. Nielsen, Andrew M. Petzold, Tammy M. Greenwood, Yonghe Ding, Xiaolei Xu, Victoria M. Bedell, Sridhar Sivasubbu, Kimberly J. Skuster, Stephanie E. Westcot, Vinod Scaria, Jun Ni, Matthias Hammerschmidt
Publikováno v: Nature methods
We describe a conditional in vivo protein-trap mutagenesis system that reveals spatiotemporal protein expression dynamics and can be used to assess gene function in the vertebrate Danio rerio. Integration of pGBT-RP2.1 (RP2), a gene-breaking transpos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728005f24096b5ce64012d222cc18283
http://europepmc.org/articles/PMC3306164
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9
Transgenic zebrafish using transposable elements
Autor: Stephen C. Ekker, Karl J. Clark, Mark D. Urban, Kimberly J. Skuster
Publikováno v: Methods in cell biology. 104
DNA transposons are effective chromosomal engineering vehicles for making transgenic zebrafish. We describe both autonomous and non-autonomous transposable elements, and we compare and contrast popular transposon systems. The Tol2 system is a robust
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a99782f134893a4adb3c5f4b9cb4ec0
https://pubmed.ncbi.nlm.nih.gov/21924161
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10
How to skin a fish: The Zebrafish Integument Project and novel epidermal mutant wicked witch of the Midwest
Autor: Darius Balciunas, Mark D. Urban, Gary L. Moulder, Sridhar Sivasubbu, Kimberly J. Skuster, Tammy M. Greenwood, Karl J. Clark, Stephanie E. Westcot, Stephen C. Ekker
Publikováno v: Developmental Biology. 356(1)
Program/Abstract # 171 The Nrf2/Keap1 pathway acts as an epidermal sentinel in utero to ensure the formation of a functional barrier Aaron Huebner, Ed Schmidt, Sabine Werner, Dennis Roop University of Colorado, Denver Cell Biology, Stem Cells & Devel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3727eb5fbcefdb47e3b266467d54b66
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