Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Kimberly G Malphrus"'
Autor:
Olivia J Conway, Minerva M Carrasquillo, Xue Wang, Jenny M Bredenberg, Joseph S Reddy, Samantha L Strickland, Curtis S Younkin, Jeremy D Burgess, Mariet Allen, Sarah J Lincoln, Thuy Nguyen, Kimberly G Malphrus, Alexandra I Soto, Ronald L Walton, Bradley F Boeve, Ronald C Petersen, John A Lucas, Tanis J Ferman, William P Cheshire, Jay A van Gerpen, Ryan J Uitti, Zbigniew K Wszolek, Owen A Ross, Dennis W Dickson, Neill R Graff-Radford, Nilüfer Ertekin-Taner
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-12 (2018)
Abstract Background Rare coding variants ABI3_rs616338-T and PLCG2_rs72824905-G were identified as risk or protective factors, respectively, for Alzheimer’s disease (AD). Methods We tested the association of these variants with five neurodegenerati
Externí odkaz:
https://doaj.org/article/26aae77c26cb4a6c9e381ff00070adea
Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants.
Autor:
Fanggeng Zou, High Seng Chai, Curtis S Younkin, Mariet Allen, Julia Crook, V Shane Pankratz, Minerva M Carrasquillo, Christopher N Rowley, Asha A Nair, Sumit Middha, Sooraj Maharjan, Thuy Nguyen, Li Ma, Kimberly G Malphrus, Ryan Palusak, Sarah Lincoln, Gina Bisceglio, Constantin Georgescu, Naomi Kouri, Christopher P Kolbert, Jin Jen, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Lindsay A Farrer, Gerard D Schellenberg, Alzheimer's Disease Genetics Consortium, Ronald C Petersen, Neill R Graff-Radford, Dennis W Dickson, Steven G Younkin, Nilüfer Ertekin-Taner
Publikováno v:
PLoS Genetics, Vol 8, Iss 6, p e1002707 (2012)
Genetic variants that modify brain gene expression may also influence risk for human diseases. We measured expression levels of 24,526 transcripts in brain samples from the cerebellum and temporal cortex of autopsied subjects with Alzheimer's disease
Externí odkaz:
https://doaj.org/article/a148bd6289944186a3a7dd01c3a33cac
Autor:
Joseph S. Reddy, Mariet Allen, Charlotte C. G. Ho, Stephanie R. Oatman, Özkan İş, Zachary S. Quicksall, Xue Wang, Jiangli Jin, Tulsi A. Patel, Troy P. Carnwath, Thuy T. Nguyen, Kimberly G. Malphrus, Sarah J. Lincoln, Minerva M. Carrasquillo, Julia E. Crook, Takahisa Kanekiyo, Melissa E. Murray, Guojun Bu, Dennis W. Dickson, Nilüfer Ertekin-Taner
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-15 (2021)
Abstract Cerebral amyloid angiopathy (CAA) contributes to accelerated cognitive decline in Alzheimer’s disease (AD) dementia and is a common finding at autopsy. The APOEε4 allele and male sex have previously been reported to associate with increas
Externí odkaz:
https://doaj.org/article/9ecb955c84c24e09bbe549b3fd5de20b
Autor:
Xue Wang, Mariet Allen, Özkan İş, Joseph S. Reddy, Frederick Q. Tutor-New, Monica Castanedes Casey, Minerva M. Carrasquillo, Stephanie R. Oatman, Yuhao Min, Yan W. Asmann, Cory Funk, Thuy Nguyen, Charlotte C.G. Ho, Kimberly G. Malphrus, Nicholas T. Seyfried, Allan I. Levey, Steven G. Younkin, Melissa E. Murray, Dennis W. Dickson, Nathan D. Price, Todd E. Golde, Nilüfer Ertekin-Taner
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)
Vast numbers of differentially expressed genes and perturbed networks have been identified in Alzheimer’s disease (AD), however, neither disease nor brain region specificity of these transcriptome alterations has been explored. Using RNA-Seq data f
Externí odkaz:
https://doaj.org/article/2242f790f53844dcac6524978cd16895
Autor:
Xue Wang, Mariet Allen, Shaoyu Li, Zachary S. Quicksall, Tulsi A. Patel, Troy P. Carnwath, Joseph S. Reddy, Minerva M. Carrasquillo, Sarah J. Lincoln, Thuy T. Nguyen, Kimberly G. Malphrus, Dennis W. Dickson, Julia E. Crook, Yan W. Asmann, Nilüfer Ertekin-Taner
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/502adc28235245b9b111474bfd61b34b
Autor:
John A. Lucas, Kimberly G. Malphrus, Minerva M. Carrasquillo, Joseph S. Reddy, Olivia J. Conway, Mariet Allen, Zbigniew K. Wszolek, Owen A. Ross, Christian C. Prusinski, Hélène Morel, Tanis J. Ferman, Neill R. Graff-Radford, Sarah Lincoln, Alexandra I. Soto, Ronald C. Petersen, Julia E. Crook, Dennis W. Dickson, Thuy Nguyen, Tulsi A. Patel, Ryan J. Uitti, Ronald L. Walton, Samantha L. Strickland, Bradley F. Boeve, Melissa E. Murray, Nilufer Ertekin-Taner
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-12 (2020)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Missense variants ABI3_rs616338-T and PLCG2_rs72824905-G were previously associated with elevated or reduced risk of Alzheimer’s disease (AD), respectively. Despite reports of associations with other neurodegenerative diseases, there are few studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a1afe3563714df6146653177a70556
http://link.springer.com/article/10.1186/s40478-020-01050-0
http://link.springer.com/article/10.1186/s40478-020-01050-0
Autor:
Julia E. Crook, Nilufer Ertekin-Taner, Joseph S. Reddy, Tulsi A. Patel, Shaoyu Li, Sarah Lincoln, Minerva M. Carrasquillo, Thuy T. Nguyen, Dennis W. Dickson, Troy P. Carnwath, Kimberly G. Malphrus, Xue Wang, Yan W. Asmann, Mariet Allen, Zachary S. Quicksall
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-15 (2020)
Molecular Neurodegeneration
Molecular Neurodegeneration
Large-scale brain bulk-RNAseq studies identified molecular pathways implicated in Alzheimer’s disease (AD), however these findings can be confounded by cellular composition changes in bulk-tissue. To identify cell intrinsic gene expression alterati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f35c8dda98dd3a97de940bde16a4043
http://link.springer.com/article/10.1186/s13024-020-00392-6
http://link.springer.com/article/10.1186/s13024-020-00392-6
Autor:
Steven G. Younkin, Todd E. Golde, Dennis W. Dickson, Joseph S. Reddy, Yuhao Min, Monica Castanedes Casey, Nicholas T. Seyfried, Stephanie R Oatman, Kimberly G. Malphrus, Nathan D. Price, Xue Wang, Thuy Nguyen, Özkan İş, Frederick Q. Tutor-New, Minerva M. Carrasquillo, Cory C. Funk, Charlotte C.G. Ho, Nilufer Ertekin-Taner, Allan I. Levey, Melissa E. Murray, Yan W. Asmann, Mariet Allen
Publikováno v:
The Journal of Clinical Investigation
Vast numbers of differentially expressed genes and perturbed networks have been identified in Alzheimer’s disease (AD), however, neither disease nor brain region specificity of these transcriptome alterations has been explored. Using RNA-Seq data f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e497f538e0cfd45712e48d9159b2872
https://doi.org/10.1172/jci149904
https://doi.org/10.1172/jci149904
Autor:
Özkan İş, Xue Wang, Tulsi A. Patel, Zachary S. Quicksall, Michael G. Heckman, Launia J. White, Laura J. Lewis-Tuffin, Kaancan Deniz, Frederick Q. Tutor-New, Troy P. Carnwath, Yuhao Min, Stephanie R. Oatman, Joseph S. Reddy, Minerva M. Carrasquillo, Thuy T. Nguyen, Charlotte C. G. Ho, Kimberly G. Malphrus, Kwangsik Nho, Andrew J. Saykin, Melissa E. Murray, Dennis W. Dickson, Mariet Allen, Nilüfer Ertekin-Taner
Blood-brain barrier (BBB) dysfunction is well-known in Alzheimer’s disease (AD), but the precise molecular changes contributing to its pathophysiology are unclear. To understand the transcriptional changes in brain vascular cells, we performed sing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e7513daab6bc8f1b6054ef710984bb5
https://doi.org/10.1101/2021.12.28.474255
https://doi.org/10.1101/2021.12.28.474255
Autor:
Minerva M. Carrasquillo, Jianli Jin, Joseph S. Reddy, Julia E. Crook, Sarah J. Lincoln, Charlotte C.G. Ho, Kimberly G. Malphrus, Thuy Nguyen, Maria T. Greig‐Custo, John A. Lucas, Neill R. Graff‐Radford, Nilufer Ertekin‐Taner
Publikováno v:
Alzheimer's & Dementia. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb7c49437af69dce3328174614fd2339
https://doi.org/10.1002/alz.055643
https://doi.org/10.1002/alz.055643