Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Kimberly Forsten-Williams"'
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 10, p e1000971 (2010)
Circulation is an important delivery method for both natural and synthetic molecules, but microenvironment interactions, regulated by endothelial cells and critical to the molecule's fate, are difficult to interpret using traditional approaches. In t
Externí odkaz:
https://doaj.org/article/f0f0487167e940108542d7ecbebb2c99
Publikováno v:
SLAS Discovery. 22:166-175
Ligand binding plays a fundamental role in stimulating the downstream signaling of membrane receptors. Here, ligand-binding kinetics of the full-length human adenosine A2A receptor (A2AR) reconstituted in detergent micelles were measured using a fluo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bc4c1c709c04b1316bcceac1a3b4987
https://doi.org/10.1177/1087057116667256
https://doi.org/10.1177/1087057116667256
Publikováno v:
SLAS discovery : advancing life sciences RD. 22(2)
Ligand binding plays a fundamental role in stimulating the downstream signaling of membrane receptors. Here, ligand-binding kinetics of the full-length human adenosine receptor A2A (A2AR) reconstituted in detergent micelles were measured using a fluo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::783a6c8c5ff617f5ed7f4da9564614ae
https://pubmed.ncbi.nlm.nih.gov/27577981
https://pubmed.ncbi.nlm.nih.gov/27577981
Publikováno v:
IEEE Transactions on Biomedical Engineering. 56:2147-2155
A novel convection--diffusion--reaction model is developed to simulate fibroblast growth factor (FGF-2) binding to cell surface receptors (FGFRs) and heparan sulfate proteoglycans (HSPGs) under flow conditions within a cylindrical-shaped vessel or ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::692cc87e17c150159eab63fd9116f4fb
https://doi.org/10.1109/tbme.2008.2002109
https://doi.org/10.1109/tbme.2008.2002109
Publikováno v:
Journal of Biological Chemistry. 283:34796-34807
We investigated the mechanism by which heparin enhances the binding of vascular endothelial growth factor (VEGF) to the extracellular matrix protein fibronectin. In contrast to other systems, where heparin acts as a protein scaffold, we found that he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61585617fa905b28fd3a7029226eff05
https://doi.org/10.1074/jbc.m806692200
https://doi.org/10.1074/jbc.m806692200
Autor:
Chia Lin Chu, Matthew A. Nugent, Kimberly Forsten-Williams, Michael Fannon, Jo Ann Buczek-Thomas
Publikováno v:
Annals of Biomedical Engineering. 36:2134-2148
Growth factor binding to transmembrane protein receptors is generally understood to initiate cell signaling. Receptor binding of heparin-binding growth factors (HB-GFs), such as fibroblast growth factor-2 (FGF-2), is regulated by interactions with he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e637c6e64f706016e318679ffc2dd6f1
https://doi.org/10.1007/s10439-008-9575-z
https://doi.org/10.1007/s10439-008-9575-z
Publikováno v:
Tissue Engineering. 13:1333-1345
Alginate hydrogel culture has been shown to reestablish chondrocytic phenotype following monolayer expansion; however, previous studies have not adequately addressed how culture conditions affect the signaling systems responsible for chondrocyte meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2760c23bb049171b0f4f866d0cc3f24
https://doi.org/10.1089/ten.2006.0345
https://doi.org/10.1089/ten.2006.0345
Publikováno v:
Traffic. 6:978-990
Several lines of evidence support a novel model for Golgi protein residency in which these proteins cycle between the Golgi apparatus and the endoplasmic reticulum (ER). However, to preserve the functional distinction between the two organelles, this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e777cefc8486b8033ae6b018a844cfe
https://doi.org/10.1111/j.1600-0854.2005.00333.x
https://doi.org/10.1111/j.1600-0854.2005.00333.x
Autor:
Thomas E. Ryan, Luz Padro, Theresa R. Cassino, Manoj Gopalakrishnan, Uwe C. Täuber, Kimberly Forsten-Williams
Publikováno v:
European Biophysics Journal. 34:943-958
Rebinding of dissociated ligands from cell surface proteins can confound quantitative measurements of dissociation rates important for characterizing the affinity of binding interactions. This can be true also for in vitro techniques such as surface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91cdf2be5e0453a6522ee95f92f7dc0d
https://doi.org/10.1007/s00249-005-0471-2
https://doi.org/10.1007/s00249-005-0471-2
Publikováno v:
Journal of Theoretical Biology. 233:483-499
Binding of growth factors to specific cell surface receptors is the first step in initiating cell signaling cascades that ultimately result in diverse activities such as proliferation, differentiation, and apoptosis. Dimerization and phosphorylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66180f65d69ae0c3c2c8407f42d606ff
https://doi.org/10.1016/j.jtbi.2004.10.020
https://doi.org/10.1016/j.jtbi.2004.10.020