Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Kimberly F. Raab‐Graham"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Tuberous Sclerosis Complex (TSC) is a lynchpin disorder, as it results in overactive mammalian target of rapamycin (mTOR) signaling, which has been implicated in a multitude of disease states. TSC is an autosomal dominant disease where 90% of affecte
Externí odkaz:
https://doaj.org/article/6ec10576de2a4647986ca00884b6d494
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2024)
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. In the mature brain, inhibitory GABAergic signaling is critical in maintaining neuronal homeostasis and vital human behaviors such as cognition,
Externí odkaz:
https://doaj.org/article/4f1edb8a2d204b718ed7861d60ec7d51
Autor:
Taylor A. Stowe, Elizabeth G. Pitts, Amy C. Leach, Melody C. Iacino, Farr Niere, Benjamin Graul, Kimberly F. Raab-Graham, Jordan T. Yorgason, Mark J. Ferris
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110633- (2022)
Summary: Dysregulation of biological rhythms plays a role in a wide range of psychiatric disorders. We report mechanistic insights into the rhythms of rapid dopamine signals and cholinergic interneurons (CINs) working in concert in the rodent striatu
Externí odkaz:
https://doaj.org/article/e65a09e0a96340b9b7975129f73d156b
Autor:
Eva C. Bach, James W. Morgan, Sarah E. Ewin, Samuel H. Barth, Kimberly F. Raab-Graham, Jeffrey L. Weiner
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Alcohol use disorder (AUD) differentially impacts men and women and a growing body of evidence points to sex-dependent adaptations in a number of brain regions. In a prior study, we explored the effect of a chronic intermittent ethanol exposure (CIE)
Externí odkaz:
https://doaj.org/article/1d7ec75b247746a8bacf13b46d437538
Autor:
Sarah A. Wolfe, Emily R. Workman, Chelcie F. Heaney, Farr Niere, Sanjeev Namjoshi, Luisa P. Cacheaux, Sean P. Farris, Michael R. Drew, Boris V. Zemelman, R. Adron Harris, Kimberly F. Raab-Graham
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Alcohol is thought to lead to neuroadaptive changes, although the underlying molecular mechanisms are unclear. Here, the authors find ethanol treatment alters GABAB-receptor expression via fragile-X mental retardation protein in mice, leading to anti
Externí odkaz:
https://doaj.org/article/e5cec5c74cef40f9abc05988792bd8e3
Publikováno v:
Neurobiology of Disease, Vol 73, Iss , Pp 96-105 (2015)
Changes in ion channel expression are implicated in the etiology of epilepsy. However, the molecular leading to long-term aberrant expression of ion channels are not well understood. The mechanistic/mammalian target of rapamycin (mTOR) is a serine/th
Externí odkaz:
https://doaj.org/article/b62f6df02b114c0eb14f3695ec73f766
Autor:
Farr Niere, Kimberly F. Raab-Graham
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) serves as a regulator of mRNA translation. Recent studies suggest that mTORC1 may also serve as a local, voltage sensor in the postsynaptic region of neurons. Considering biochemical, b
Externí odkaz:
https://doaj.org/article/23ebbb9980f24994b8ea8c9de29b6776
Autor:
Eva C. Bach, Sarah E. Ewin, Chelcie F. Heaney, Hannah N. Carlson, Olivia A. Ortelli, Antoine G. Almonte, Ann M. Chappell, Kimberly F. Raab‐Graham, Jeffrey L. Weiner
Publikováno v:
European Journal of Neuroscience. 57:1241-1259
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::886f9d7508950ab1b442ea322284643d
https://doi.org/10.1111/ejn.15944
https://doi.org/10.1111/ejn.15944
Autor:
null Eva C. Bach, null Sarah E. Ewin, null Chelcie F. Heaney, null Hannah N. Carlson, null Olivia A. Ortelli, null Antoine G. Almonte, null Ann M. Chappell, null Kimberly F. Raab‐Graham, null Jeffrey L. Weiner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53eeb787490f510c786b12dcae16df4d
https://doi.org/10.1111/ejn.15944/v2/response1
https://doi.org/10.1111/ejn.15944/v2/response1
Publikováno v:
Journal of Visualized Experiments.
Synapses are the site of communication between neurons. Neuronal circuit strength is related to synaptic density, and the breakdown of synapses is characteristic of disease states like major depressive disorder (MDD) and Alzheimer's disease. Traditio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec20189948e8a5c677518ca6ae90dde6
https://doi.org/10.3791/63139
https://doi.org/10.3791/63139