Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kimberly F. Macala"'
Autor:
Manoj M. Lalu, Dawn Richards, Madison Foster, Brittany French, Angela M. Crawley, Kirsten M. Fiest, Kathryn Hendrick, Kimberly F. Macala, Asher A. Mendelson, Pat Messner, Stuart G. Nicholls, Justin Presseau, Cheryle A. Séguin, Patrick Sullivan, Bernard Thébaud, Dean A. Fergusson
Publikováno v:
Research Involvement and Engagement, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Background Patient engagement in research is the meaningful and collaborative interaction between patients and researchers throughout the research process. Patient engagement can help to ensure patient-oriented values and perspectives are in
Externí odkaz:
https://doaj.org/article/d1346b77fe94404e9245270fe80b7977
Autor:
Neha Sharma, Damian Chwastek, Dhruva J. Dwivedi, Jared Schlechte, Ian-Ling Yu, Braedon McDonald, Jaskirat Arora, Erblin Cani, Mikaela Eng, Doreen Engelberts, Eva Kuhar, Sarah K. Medeiros, Stephane L. Bourque, Gediminas Cepinskas, Sean E. Gill, Forough Jahandideh, Kimberly F. Macala, Sareh Panahi, Cynthia Pape, David Sontag, Janet Sunohara-Neilson, Dean A. Fergusson, Alison E. Fox-Robichaud, Patricia C. Liaw, Manoj M. Lalu, Asher A. Mendelson, for the National Preclinical Sepsis Platform, Sepsis Canada
Publikováno v:
Intensive Care Medicine Experimental, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Background Preclinical sepsis models have been criticized for their inability to recapitulate human sepsis and suffer from methodological shortcomings that limit external validity and reproducibility. The National Preclinical Sepsis Platform
Externí odkaz:
https://doaj.org/article/2a7fa924fb5b4658b0da38387de75a6e
Autor:
MengQi Zhang, Dean A. Fergusson, Rahul Sharma, Ciel Khoo, Asher A. Mendelson, Braedon McDonald, Kimberly F. Macala, Neha Sharma, Sean E. Gill, Kirsten M. Fiest, Christian Lehmann, Risa Shorr, Forough Jahandideh, Stephane L. Bourque, Patricia C. Liaw, Alison Fox-Robichaud, Manoj M. Lalu, on behalf of the Canadian Critical Care Translational Biology Group, the Sepsis Canada National Preclinical Sepsis Platform
Publikováno v:
Systematic Reviews, Vol 12, Iss 1, Pp 1-9 (2023)
Abstract Background The importance of investigating sex- and gender-dependent differences has been recently emphasized by major funding agencies. Notably, the influence of biological sex on clinical outcomes in sepsis is unclear, and observational st
Externí odkaz:
https://doaj.org/article/19f1ce8a2d3b487d9eec9135366362f3
Autor:
Saad Y. Salim, Nour AlMalki, Kimberly F. Macala, Alyssa Wiedemeyer, Thomas F. Mueller, Thomas A. Churchill, Stephane L. Bourque, Rachel G. Khadaroo
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 483 (2023)
Sepsis remains one of the leading causes of death worldwide. Oncostatin M (OSM), an interleukin (IL)-6 family cytokine, can be found at high levels in septic patients. However, little is known about its role in sepsis. This study aimed to determine i
Externí odkaz:
https://doaj.org/article/9e6ec6197c06438bb0d4a755e66efbd6
Autor:
Grace Fox, Dean A. Fergusson, Zeinab Daham, Mark Youssef, Madison Foster, Evelyn Poole, Ayni Sharif, Dawn P. Richards, Kathryn Hendrick, Asher A. Mendelson, Kimberly F. Macala, Zarah Monfaredi, Joshua Montroy, Kirsten M. Fiest, Justin Presseau, Manoj M. Lalu
Publikováno v:
EBioMedicine, Vol 70, Iss , Pp 103484- (2021)
Background: ‘Patient engagement’ involves meaningful collaboration between researchers and ‘patient partners’ to co-create research. It helps ensure that research being conducted is relevant to its ultimate end-users. Although patient engagem
Externí odkaz:
https://doaj.org/article/adb7d3a7384c4ba58fee46815e04a397
Autor:
MengQi Zhang, BSc, Joshua Montroy, MSc, Rahul Sharma, HBSc, Dean A. Fergusson, MHA, PhD, Asher A. Mendelson, MD, PhD, FRCPC, Kimberly F. Macala, MD, FRCPC, Stephane L. Bourque, PhD, Jared M. Schlechte, BSc, Mikaela K. Eng, MSc, Braedon McDonald, MD, PhD, FRCPC, Sean E. Gill, PhD, Kirsten M. Fiest, PhD, Patricia C. Liaw, MSc, PhD, Alison Fox-Robichaud, MSc, MD, FRCPC, Manoj M. Lalu, MD, PhD, FRCPC, on behalf of the Canadian Critical Care Translational Biology Group and the Sepsis Canada National Preclinical Sepsis Platform
Publikováno v:
Critical Care Explorations, Vol 3, Iss 6, p e0433 (2021)
OBJECTIVES:. Preclinical studies provide an opportunity to evaluate the relationship between sex and sepsis, and investigate underlying mechanisms in a controlled experimental environment. The objective of our systematic review was to assess the impa
Externí odkaz:
https://doaj.org/article/3d91592aef26469088861c5e8ddfd0d5
Autor:
Forough Jahandideh, Sareh Panahi, Ronan M. N. Noble, Ferrante S. Gragasin, Rachel G. Khadaroo, Kimberly F. Macala, Stephane L. Bourque
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 470 (2022)
Sepsis is associated with circulatory dysfunction contributing to disturbed blood flow and organ injury. Decreased organ perfusion in sepsis is attributed, in part, to the loss of vasoregulatory mechanisms. Identifying which vascular beds are most su
Externí odkaz:
https://doaj.org/article/e1fbcfcb9fa64a209cc5478af76eb0e5
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202871 (2018)
BACKGROUND:Medication overdose is a prevalent issue and despite mixed reports of efficacy, the use of intravenous lipid emulsions, notably Intralipid®, for the management of toxicity from lipid-soluble drugs is becoming increasingly prevalent. Wheth
Externí odkaz:
https://doaj.org/article/596fb689b7404c16b5e65aa562da1f25
Autor:
Sean E. Gill, Ellen McDonald, Christian Lehmann, Victoria T. Hunniford, Marcin F. Osuchowski, Karla D. Krewulak, Asher A. Mendelson, Janet Sunohara-Neilson, Manoj M. Lalu, Gloria Vazquez-Grande, Kathryn Hendrick, Christopher G. Ellis, John Marshall, Sarah K. Medeiros, Sahar Sohrabipour, Dean Fergusson, Dhruva J. Dwivedi, Neha Sharma, Haibo Zhang, Kirsten M. Fiest, Claudia C. dos Santos, Laura Mawdsley, Jaskirat Arora, Gediminas Cepinskas, Alison Fox-Robichaud, Jean-François Cailhier, Patricia C. Liaw, Ryan Zarychanski, Kimberly F. Macala, Brent W. Winston, Valdirene S Muniz, Ruud A. W. Veldhuizen, Justin Presseau, Emmanuel Charbonney, Casey Lansdell, Donald G. Welsh, Juan Zhou, Paulina M. Kowalewska, Braedon McDonald
Publikováno v:
Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-19 (2021)
Intensive Care Medicine Experimental
Intensive Care Medicine Experimental
Despite decades of preclinical research, no experimentally derived therapies for sepsis have been successfully adopted into routine clinical practice. Factors that contribute to this crisis of translation include poor representation by preclinical mo
Publikováno v:
Shock. 56:178-187
In this mini-review we provide an overview of sex- and gender-dependent issues in both clinical and preclinical sepsis. The increasing recognition for the need to account for sex and gender in biomedical research brings a unique set of challenges and