Výsledky vyhledávání - "Kimberly Dunn-Meynell"

Optimizing an ultrafast generic high-performance liquid chromatography/tandem mass spectrometry method for faster discovery pharmacokinetic sample throughput

Autor: Kimberly Dunn-Meynell, Samuel Wainhaus, Walter A. Korfmacher

Publikováno v: Rapid Communications in Mass Spectrometry. 19:2905-2910

For higher throughput screening, where the number of new chemical entities (NCEs) to test is rapidly increasing, fast sample turnaround time is essential. In order to increase efficiency a generic high-performance liquid chromatography/tandem mass sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af5ba44037a70c2b2a9f7f1aa412b6d
https://doi.org/10.1002/rcm.2147

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Development of an automated mass spectrometry system for the quantitative analysis of liver microsomal incubation samples: a tool for rapid screening of new compounds for metabolic stability

Autor: Diane E. Grotz, Kimberly Dunn-Meynell, Eva Duchoslav, Kathleen Cox, Chin-Chung Lin, Chris Elicone, Charles C. Liu, Cynthia A. Palmer, Cymbelene Nardo, Walter A. Korfmacher

Publikováno v: Rapid Communications in Mass Spectrometry. 13:901-907

There is a continuing need for increased throughput in the evaluation of new drug entities in terms of their pharmacokinetic parameters. One useful parameter that can be measured in vitro using liver microsomal preparations is metabolic stability. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0cca7ca8006af11ba2776b1fb57b5f26
https://doi.org/10.1002/(sici)1097-0231(19990530)13:10<901::aid-rcm583>3.0.co

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