Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kimberly Della Penna"'
Autor:
Michael D. Leitl, Darrell A. Henze, B. Wesley Trotter, Kimberly Della Penna, Ahren Iver Green, Mark T. Bilodeau, Zhicai Wu, Christopher S. Burgey, Wei Lemaire, Stefanie A. Kane, Craig M. Potteiger, Reshma Desai, Mark O. Urban, Suzie Yeh, Rebecca B. White, Nathan R. Kett, James Z. Deng, George D. Hartman, John C. Hartnett, Kausik K. Nanda
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2354-2358
A new series of imidazopyridine CB2 agonists is described. Structural optimization improved CB2/CB1 selectivity in this series and conferred physical properties that facilitated high in vivo exposure, both centrally and peripherally. Administration o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14244f428a1317fe2d743c1692b389db
https://doi.org/10.1016/j.bmcl.2011.02.082
https://doi.org/10.1016/j.bmcl.2011.02.082
Autor:
Diem N. Nguyen, Samuel L. Graham, Theresa M. Williams, Scott D. Mosser, Ian M. Bell, Bang-Lin Wan, Kimberly Della Penna, Priya Kunapuli, Stefanie A. Kane, Craig A. Stump, Ruth Z. Rutledge, John F. Fay, Ken S. Koblan, Joseph P. Vacca, C. Blair Zartman, Steven N. Gallicchio, Amy G. Quigley, Christopher A. Salvatore
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2595-2598
High-throughput screening of the Merck sample collection identified benzodiazepinone tetralin-spirohydantoin 1 as a CGRP receptor antagonist with micromolar activity. Comparing the structure of 1 with those of earlier peptide-based antagonists such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6628f20dd0bcf6f444b0f155b9357fdc
https://doi.org/10.1016/j.bmcl.2006.02.051
https://doi.org/10.1016/j.bmcl.2006.02.051
Autor:
Jerzy Karczewski, Kimberly Della Penna, Jixin Wang, Joseph J. Salata, Thomas M. Connolly, Hao Wang, Kenneth S. Koblan, Paul B. Bennett
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 284:H256-H267
We established HEK-293 cell lines that stably express functional canine ether-à-go-go-related gene (cERG) K+ channels and examined their biophysical and pharmacological properties with whole cell patch clamp and35S-labeled MK-499 ([35S]MK-499) bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2feb88e31ba8918ec7e282c8814e441
https://doi.org/10.1152/ajpheart.00220.2002
https://doi.org/10.1152/ajpheart.00220.2002
Autor:
Darrell A. Henze, Mark T. Bilodeau, Kausik K. Nanda, Wei Lemaire, Kimberly Della Penna, Suzie Yeh, B. Wesley Trotter, Janine N. Brouillette, George D. Hartman, Michael D. Leitl, Reshma Desai, Rebecca B. White
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(4)
A new series of CB2-selective agonists containing a benzimidazole core is reported. Design, synthesis, SAR and pharmacokinetic data for selected compounds are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf50a82eeebf4c0853e663a39f8d1e02
https://pubmed.ncbi.nlm.nih.gov/24461289
https://pubmed.ncbi.nlm.nih.gov/24461289
Autor:
Michael D. Leitl, Peter J. Manley, Suzie Yeh, Daniel V. Paone, Wei Lemaire, George D. Hartman, Darrell A. Henze, Amy E. Zartman, Reshma Desai, Mark O. Urban, Kimberly Della Penna, Rebecca B. White, Mark T. Bilodeau, B. Wesley Trotter, Stefanie A. Kane, Christopher S. Burgey
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(8)
A novel series of decahydroquinoline CB2 agonists is described. Optimization of the amide substituent led to improvements in CB2/CB1 selectivity as well as physical properties. Two key compounds were examined in the rat CFA model of acute inflammator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a168ef8554eac8532c4d10c7137f30
https://pubmed.ncbi.nlm.nih.gov/21420857
https://pubmed.ncbi.nlm.nih.gov/21420857
Autor:
David Gerhold, Robert J Benz, Hao Wang, Jian Xu, Daniel J. Holder, Hong Sun, Kenneth S. Koblan, Kimberly Della Penna, Fumi Kinose
Publikováno v:
BMC Neuroscience. 3:11
Background Neurons in the dorsal spinal cord play important roles in nociception and pain. These neurons receive input from peripheral sensory neurons and then transmit the signals to the brain, as well as receive and integrate descending control sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::592ee0ea2de9e3aec24e7b7297149408
https://doi.org/10.1186/1471-2202-3-11
https://doi.org/10.1186/1471-2202-3-11