Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Kimberly D. Klarmann"'
Autor:
Brad L. Jakubison, Tanmoy Sarkar, Kristbjorn O. Gudmundsson, Shweta Singh, Lei Sun, Holly M. Morris, Kimberly D. Klarmann, Jonathan R. Keller
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)
Defining mechanism(s) that maintain tissue stem quiescence is important for improving tissue regeneration, cell therapies, aging, and cancer. We report here that genetic ablation of Id2 in adult hematopoietic stem cells (HSCs) promotes increased HSC
Externí odkaz:
https://doaj.org/article/c11c062cb0a34b3e9bd58c5127f5532d
Autor:
Velayoudame Parthibane, Diwash Acharya, Sargur Madabushi Srideshikan, Jing Lin, Dru G. Myerscough, Thiruvaimozhi Abimannan, Nagampalli Vijaykrishna, Daniel Blankenberg, Lavanya Bondada, Kimberly D. Klarmann, Stephen D. Fox, Thorkell Andresson, Lino Tessarollo, Usha Acharya, Jonathan R. Keller, Jairaj K. Acharya
Publikováno v:
Blood Advances, Vol 3, Iss 22, Pp 3635-3649 (2019)
Abstract: Serine palmitoyltransferase (SPT) long-chain base subunit 1 (SPTLC1) is 1 of the 2 main catalytic subunits of the SPT complex, which catalyzes the first and rate-limiting step of sphingolipid biosynthesis. Here, we show that Sptlc1 deletion
Externí odkaz:
https://doaj.org/article/f462def89ff74bea9877599f90c861ed
Autor:
Stephen Gadomski, Satyendra K. Singh, Shweta Singh, Tanmoy Sarkar, Kimberly D. Klarmann, Maximillian Berenschot, Steven Seaman, Brad Jakubison, Kristbjorn O. Gudmundsson, Stephen Lockett, Jonathan R. Keller
Publikováno v:
Cell Reports, Vol 31, Iss 4, Pp - (2020)
Summary: Investigating mechanisms that regulate endothelial cell (EC) growth and survival is important for understanding EC homeostasis and how ECs maintain stem cell niches. We report here that targeted loss of Id genes in adult ECs results in dilat
Externí odkaz:
https://doaj.org/article/5e00d82cb9f044aeacd238721b815f03
Autor:
Bjorg Gudmundsdottir, Kristbjorn O. Gudmundsson, Kimberly D. Klarmann, Satyendra K. Singh, Lei Sun, Shweta Singh, Yang Du, Vincenzo Coppola, Luke Stockwin, Nhu Nguyen, Lino Tessarollo, Leifur Thorsteinsson, Olafur E. Sigurjonsson, Sveinn Gudmundsson, Thorunn Rafnar, John F. Tisdale, Jonathan R. Keller
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3236-3248 (2018)
Summary: Fetal globin genes are transcriptionally silenced during embryogenesis through hemoglobin switching. Strategies to derepress fetal globin expression in the adult could alleviate symptoms in sickle cell disease and β-thalassemia. We identifi
Externí odkaz:
https://doaj.org/article/e0d1e32368d04fa6970dd5594931da2a
Autor:
Xia Ding, Arnab Ray Chaudhuri, Elsa Callen, Yan Pang, Kajal Biswas, Kimberly D. Klarmann, Betty K. Martin, Sandra Burkett, Linda Cleveland, Stacey Stauffer, Teresa Sullivan, Aashish Dewan, Hanna Marks, Anthony T. Tubbs, Nancy Wong, Eugen Buehler, Keiko Akagi, Scott E. Martin, Jonathan R. Keller, André Nussenzweig, Shyam K. Sharan
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The PARP inhibitor olaparib is an approved treatment method for women with BRCA1 and BRCA2 mutation associated cancers. Here the authors show that olaparib can contribute to synthetic viability of cells if PARP1 is inhibited before BRCA2 loss.
Externí odkaz:
https://doaj.org/article/cf505f822a744ac9ab12008610c61b55
Autor:
Howard A. Young, Niroshana Anandasabapathy, Elijah F. Edmondson, Glenn Merlino, Daniel W. McVicar, Heekyong R. Bae, Peng Jiang, Kimberly D. Klarmann, Maria E. Romero, Koichi Tsuneyama, Ian A. Bettencourt, John M. Fenimore, Jie Yin, Morgan Johnson, Megan M. Hess, Chi-Ping Day, Michael E. Sanford, Clint Allen, Paul E. Clavijo, Rebecca A. Erwin-Cohen, Julio C. Valencia
The relationship between cancer and autoimmunity is complex. However, the incidence of solid tumors such as melanoma has increased significantly among patients with previous or newly diagnosed systemic autoimmune disease (AID). At the same time, immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3a6547450165edfa3b530fe33d10b2f
https://doi.org/10.1158/0008-5472.c.6513930.v1
https://doi.org/10.1158/0008-5472.c.6513930.v1
Autor:
Howard A. Young, Niroshana Anandasabapathy, Elijah F. Edmondson, Glenn Merlino, Daniel W. McVicar, Heekyong R. Bae, Peng Jiang, Kimberly D. Klarmann, Maria E. Romero, Koichi Tsuneyama, Ian A. Bettencourt, John M. Fenimore, Jie Yin, Morgan Johnson, Megan M. Hess, Chi-Ping Day, Michael E. Sanford, Clint Allen, Paul E. Clavijo, Rebecca A. Erwin-Cohen, Julio C. Valencia
Supplementary data, including supplementary figures with figure legends below
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c757528a13c639c3f715cff565148425
https://doi.org/10.1158/0008-5472.22431531.v1
https://doi.org/10.1158/0008-5472.22431531.v1
Autor:
Jonathan R. Keller, Anthony T. Tubbs, André Nussenzweig, Can Wang, Jianke Ren, Xiaoping Xu, Yafeng He, Lei Sun, Andrew Schwader, Kathrin Muegge, Kimberly D. Klarmann, Richard Finney, Kai Ni
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance ICF4 is an inherited disease with early mortality due to immunodeficiency. Although the genetic cause is known to be a mutation in the Lsh (lymphoid-specific helicase) gene, it remains unknown why patients suffer from an impaired immune
Autor:
Diwash Acharya, Thorkell Andresson, Thiruvaimozhi Abimannan, Jing Lin, Jonathan R. Keller, Sargur Madabushi Srideshikan, Lino Tessarollo, Dru G. Myerscough, Jairaj K. Acharya, Lavanya Bondada, Usha Acharya, Nagampalli Vijaykrishna, Stephen D. Fox, Daniel Blankenberg, Velayoudame Parthibane, Kimberly D. Klarmann
Publikováno v:
Blood Advances. 3:3635-3649
Serine palmitoyltransferase (SPT) long-chain base subunit 1 (SPTLC1) is 1 of the 2 main catalytic subunits of the SPT complex, which catalyzes the first and rate-limiting step of sphingolipid biosynthesis. Here, we show that Sptlc1 deletion in adult
Autor:
Brad L. Jakubison, Tanmoy Sarkar, Kristbjorn O. Gudmundsson, Shweta Singh, Lei Sun, Holly M. Morris, Kimberly D. Klarmann, Jonathan R. Keller
Publikováno v:
The Journal of clinical investigation. 132(13)
Defining mechanism(s) that maintain tissue stem quiescence is important for improving tissue regeneration, cell therapies, aging, and cancer. We report here that genetic ablation of Id2 in adult hematopoietic stem cells (HSCs) promotes increased HSC