Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Kimberly D. Callaghan"'
Autor:
Jacqueline G. Stonehuerner, Kimberly D. Callaghan, Andrew J. Ghio, David J. Haile, Funmei Yang, Judy H. Richards, Ngoc Bich Nguyen
Publikováno v:
BioMetals. 23:657-667
Exposure to bleomycin can result in an inflammatory lung injury. The biological effect of this anti-neoplastic agent is dependent on its coordination of iron with subsequent oxidant generation. In lung cells, divalent metal transporter 1 (DMT1) can p
Autor:
Kimberly D. Callaghan, Zhongping Deng, Ngoc Bich Nguyen, Andrew J. Ghio, Michael D. Madden, Jacqueline G. Stonehuerner, Funmei Yang, Lisa A. Dailey, Claude A. Piantadosi, Judy H. Richards
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 38:715-723
The dissociation of iron from heme is a major factor in iron metabolism and the cellular concentrations of the metal correlate with heme degradation. We tested the hypotheses that (1) exposure to a product of heme catabolism, carbon monoxide (CO), al
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 291:L417-L425
Alveolar macrophages express many proteins important in iron homeostasis, including the iron importer divalent metal transport 1 (DMT1) and the iron exporter ferroportin 1 (FPN1) that likely participate in lung defense. We found the iron regulatory h