Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

Autor: Atiqur Rahman, Katherine M Henry, Kimberly D Herman, Alfred AR Thompson, Hannah M Isles, Claudia Tulotta, David Sammut, Julien JY Rougeot, Nika Khoshaein, Abigail E Reese, Kathryn Higgins, Caroline Tabor, Ian Sabroe, William J Zuercher, Caroline O Savage, Annemarie H Meijer, Moira KB Whyte, David H Dockrell, Stephen A Renshaw, Lynne R Prince

Publikováno v: eLife, Vol 8 (2019)

Neutrophilic inflammation with prolonged neutrophil survival is common to many inflammatory conditions, including chronic obstructive pulmonary disease (COPD). There are few specific therapies that reverse neutrophilic inflammation, but uncovering me

Externí odkaz: https://doaj.org/article/fe7fcfe76891424e9fe5d095f6489f95

The CXCL12/CXCR4 Signaling Axis Retains Neutrophils at Inflammatory Sites in Zebrafish

Autor: Hannah M. Isles, Kimberly D. Herman, Anne L. Robertson, Catherine A. Loynes, Lynne R. Prince, Philip M. Elks, Stephen A. Renshaw

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

The inappropriate retention of neutrophils at inflammatory sites is a major driver of the excessive tissue damage characteristic of respiratory inflammatory diseases including COPD, ARDS, and cystic fibrosis. The molecular programmes which orchestrat

Externí odkaz: https://doaj.org/article/e3c17c21cf4049ceb1d3ced802a3e8bb

Isolation and high throughput flow cytometric apoptosis assay of human neutrophils to enable compound library screening

Autor: Lynne R. Prince, Kimberly D Herman, Atiqur Rahman

Publikováno v: Bio-protocol
Bio Protoc

The study of human neutrophils in vitro is challenging due to their short half-life and propensity for activation. However, with careful handling and manipulation in the laboratory, they can be a powerful tool to investigate immune responses in healt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef53919b826a52a4abe8efe02476d385
https://eprints.whiterose.ac.uk/171999/1/Bio-protocol3640.pdf

Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

Autor: Hannah M. Isles, Annemarie H. Meijer, Julien Rougeot, Stephen A. Renshaw, Kathryn R. Higgins, Caroline Tabor, Claudia Tulotta, Moira K. B. Whyte, Abigail E Reese, Atiqur Rahman, Aar Thompson, Lynne R. Prince, Kimberly D Herman, Katherine M. Henry, David H. Dockrell, Nika Khoshaein, Caroline O. S. Savage, David Sammut, William J. Zuercher, Ian Sabroe

Publikováno v: eLife
eLife, 8, e50990
Rahman, A, Henry, K M, Herman, K D, Thompson, A A, Isles, H M, Tulotta, C, Sammut, D, Rougeot, J J, Khoshaein, N, Reese, A E, Higgins, K, Tabor, C, Sabroe, I, Zuercher, W J, Savage, C O, Meijer, A H, Whyte, M K, Dockrell, D H, Renshaw, S A & Prince, L R 2019, ' Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation ', eLIFE, vol. 8 . https://doi.org/10.7554/eLife.50990
eLife, Vol 8 (2019)

Neutrophilic inflammation with prolonged neutrophil survival is common to many inflammatory conditions, including chronic obstructive pulmonary disease (COPD). There are few specific therapies that reverse neutrophilic inflammation, but uncovering me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b59e3fc62c3c598a92603ab84ee828
https://pubmed.ncbi.nlm.nih.gov/31613219